위샘암종 환자에서 발견된 항Hu항체
Anti-Hu Antibody-Mediated Myelopathy Associated with Gastric Adenocarcinoma
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Anti-Hu antibody causes paraneoplastic syndrome of the nervous system. Most of the anti-Hu antibodies are found with small cell lung cancer, but can rarely be found with other cancers such as non-small cell lung cancer, prostate cancer, and breast cancer. We report a 57-year-old male patient with advanced gastric adenocarcinoma who had paresthesia and limb ataxia. Electrophysiologic study and imaging showed peripheral neuropathy accompanied with myelitis. Anti-Hu antibody was detected in the patient’s serum, leading to the diagnosis of paraneoplastic syndrome
Abstract
Anti-Hu antibody causes paraneoplastic syndrome of the nervous system. Most of the anti-Hu antibodies are found with small cell lung cancer, but can rarely be found with other cancers such as non-small cell lung cancer, prostate cancer, and breast cancer. We report a 57-year-old male patient with advanced gastric adenocarcinoma who had paresthesia and limb ataxia. Electrophysiologic study and imaging showed peripheral neuropathy accompanied with myelitis. Anti-Hu antibody was detected in the patient’s serum, leading to the diagnosis of paraneoplastic syndrome
참고문헌 (10)
- 김광국, "방종양성증후군", 대한신경과학회지, 20(3), pp.215~222 (2002), 대한신경과학회
- Lucchinetti CF, "Paraneoplastic and oncologic profiles of patients seropositive for type 1 antineuronal nuclear autoantibodies", Neurology, 50, pp.652~657 (1998)
- McKeon A, "Paraneoplastic encephalomyelopathies : pathology and mechanisms", Acta Neuropathol, 122, pp.381~400 (2011)
- Graus F, "Anti-Hu-associated paraneoplastic encephalomyelitis : analysis of 200 patients", Brain, 124, pp.1138~1148 (2001)
- Sillevis Smitt P, "Survival and outcome in 73 anti-Hu positive patients with paraneoplastic encephalomyelitis", sensory neuronopathy, 2002, pp.249, 745~753
- Flanagan EP, "Paraneoplastic isolated myelopathy : clinical course and neuroimaging clues", Neurology, 76, pp.2089~2095 (2011)
- Shah S, "Paraneoplastic myeloneuropathies", Neurology, 96, pp.e632~e639 (2021)
- Andrès E, "The pathophysiology of elevated vitamin B12 in clinical practice", QJM, 106, pp.505~515 (2013)
- Graus F, "Updated diagnostic criteria for paraneoplastic neurologic syndromes", Neurol Neuroimmunol Neuroinflamm, 8, pp.e1014~ (2021)
- Uneno Y, "Paraneoplastic limbic encephalitis in a human epidermal growth factor receptor-2-positive gastric cancer patient treated with trastuzumab-combined chemotherapy : a case report and literature review", Intern Med, 55, pp.2605~2609 (2016)