본문 바로가기
KERD
논문KCI 등재

시신경척수염범위질환 치료의 최신 지견

Advances in the Treatment of Neuromyelitis Optica Spectrum Disorder

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류신경과학

초록

Treatment options for patients with neuromyelitis optica spectrum disorders (NMOSD) so far have relied on off-label and empiric drugs. Advances in the understanding of NMOSD pathogenesis have led to the development of highly effective disease-modifying therapies, and for the first time in this disease, class I treatment evidence is available. We aim to shortly summarize the pathogenesis and biological targets for acute and preventive therapy of patients with NMOSD. We focus on conventional immunotherapies and the recently approved novel biological drugs, eculizumab, inebilizumab, and satralizumab, and conclude with a brief outlook on future therapeutic approaches

Abstract

Treatment options for patients with neuromyelitis optica spectrum disorders (NMOSD) so far have relied on off-label and empiric drugs. Advances in the understanding of NMOSD pathogenesis have led to the development of highly effective disease-modifying therapies, and for the first time in this disease, class I treatment evidence is available. We aim to shortly summarize the pathogenesis and biological targets for acute and preventive therapy of patients with NMOSD. We focus on conventional immunotherapies and the recently approved novel biological drugs, eculizumab, inebilizumab, and satralizumab, and conclude with a brief outlook on future therapeutic approaches

참고문헌 (61)

  1. Wingerchuk DM, "International consensus diagnostic criteria for neuromyelitis optica spectrum disorders", Neurology, 85, pp.177~189 (2015)
  2. Mori M, "Worldwide prevalence of neuromyelitis optica spectrum disorders", J Neurol Neurosurg Psychiatry, 89, pp.555~556 (2018)
  3. Flanagan EP, "Epidemiology of aquaporin-4 autoimmunity and neuromyelitis optica spectrum", Ann Neurol, 79, pp.775~783 (2016)
  4. Jarius S, "Neuromyelitis optica", Nat Rev Dis Primers, 6, pp.85~ (2020)
  5. Jarius S, "MOG-IgG in NMO and related disorders: a multicenter study of 50patients. Part 3: brainstem involvement - frequency, presentation and outcome", J Neuroinflammation, 13, pp.281~ (2016)
  6. Bennett JL, "B lymphocytes in neuromyelitis optica", Neurol Neuroimmunol Neuroinflamm, 2, pp.e104~ (2015)
  7. Stiebel-Kalish H, "Does time equal vision in the acute treatment of a cohort of AQP4 and MOG optic neuritis?", Neurol Neuroimmunol Neuroinflamm, 6, pp.e572~ (2019)
  8. Kleiter I, "Apheresis therapies for NMOSD attacks : a retrospective study of 207 therapeutic interventions", Neurol Neuroimmunol Neuroinflamm, 5, pp.e504~ (2018)
  9. 김수현, "Clinical Efficacy of Plasmapheresis in Patients with Neuromyelitis Optica Spectrum Disorder and Effects on Circulating Anti-Aquaporin-4 Antibody Levels", Journal of Clinical Neurology, 9(1), pp.36~42 (2013), 대한신경과학회[DOI]
  10. Bonnan M, "Plasma exchange in severe attacks of neuromyelitis optica", Mult Scler Int, 2012, pp.787630~ (2012)
  11. Kleiter I, "Neuromyelitis optica : evaluation of 871 attacks and 1, 153 treatment courses", Ann Neurol, 79, pp.206~216 (2016)
  12. Schwab I, "Intravenous immunoglobulin therapy : how does IgG modulate the immune system?", Nat Rev Immunol, 13, pp.176~189 (2013)
  13. Elsone L, "Role of intravenous immunoglobulin in the treatment of acute relapses of neuromyelitis optica : experience in 10 patients", Mult Scler, 20, pp.501~504 (2014)
  14. Lin J, "Intravenous immunoglobulin as the rescue treatment in NMOSD patients", Neurol Sci, 42, pp.3857~3863 (2021)
  15. Costanzi C, "Azathioprine : tolerability, efficacy, and predictors of benefit in neuromyelitis optica", Neurology, 77, pp.659~666 (2011)
  16. Elsone L, "Long-term efficacy, tolerability and retention rate of azathioprine in 103 aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder patients : a multicentre retrospective observational study from the UK", Mult Scler, 20, pp.1533~1540 (2014)
  17. Jiao Y, "Dose effects of mycophenolate mofetil in Chinese patients with neuromyelitis optica spectrum disorders : a case series study", BMC Neurol, 18, pp.47~ (2018)
  18. Chen H, "The Efficacy and tolerability of mycophenolate mofetil in treating neuromyelitis optica and neuromyelitis optica spectrum disorder in Western China", Clin Neuropharmacol, 39, pp.81~87 (2016)
  19. Huh SY, "Mycophenolate mofetil in the treatment of neuromyelitis optica spectrum disorder", JAMA Neurol, 71, pp.1372~1378 (2014)
  20. Jacob A, "Treatment of neuromyelitis optica with mycophenolate mofetil : retrospective analysis of 24 patients", Arch Neurol, 66, pp.1128~1133 (2009)
  21. Chen H, "Comparisons of the efficacy and tolerability of mycophenolate mofetil and azathioprine as treatments for neuromyelitis optica and neuromyelitis optica spectrum disorder", Eur J Neurol, 24, pp.219~226 (2017)
  22. Yang Y, "Comparison of efficacy and tolerability of azathioprine, mycophenolate mofetil, and lower dosages of rituximab among patients with neuromyelitis optica spectrum disorder", J Neurol Sci, 385, pp.192~197 (2018)
  23. Cree BA, "An open label study of the effects of rituximab in neuromyelitis optica", Neurology, 64, pp.1270~1272 (2005)
  24. Kim SH, "Repeated treatment with rituximab based on the assessment of peripheral circulating memory B cells in patients with relapsing neuromyelitis optica over 2 years", Arch Neurol, 68, pp.1412~1420 (2011)
  25. Pellkofer HL, "Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab", Neurology, 76, pp.1310~1315 (2011)
  26. Kim SH, "A 5-year follow-up of rituximab treatment in patients with neuromyelitis optica spectrum disorder", JAMA Neurol, 70, pp.1110~1117 (2013)
  27. Kim SH, "Treatment Outcomes With rituximab in 100 patients with neuromyelitis optica : influence of FCGR3A polymorphisms on the therapeutic response to rituximab", JAMA Neurol, 72, pp.989~995 (2015)
  28. Olivieri G, "Rituximab as a first-line treatment in pediatric neuromyelitis optica spectrum disorder", Neurol Sci, 36, pp.2301~2302 (2015)
  29. Zephir H, "Rituximab as first-line therapy in neuromyelitis optica : efficiency and tolerability", J Neurol, 262, pp.2329~2335 (2015)
  30. Kim SH, "Less frequent rituximab retreatment maintains remission of neuromyelitis optica spectrum disorder, following long-term rituximab treatment", J Neurol Neurosurg Psychiatry, 90, pp.486~487 (2019)
  31. Tahara M, "Safety and efficacy of rituximab in neuromyelitis optica spectrum disorders(RIN-1 study) : a multicentre, randomised, double-blind, placebo-controlled trial", Lancet Neurol, 19, pp.298~306 (2020)
  32. Cohen M, "Monitoring CD27+ memory B-cells in neuromyelitis optica spectrum disorders patients treated with rituximab : Results from a bicentric study", J Neurol Sci, 373, pp.335~338 (2017)
  33. Lebrun C, "only follow-up of memory B cells helps monitor rituximab administration to patients with neuromyelitis optica spectrum disorders", Neurol Ther, 7, pp.373~383 (2018)
  34. Ellwardt E, "Monitoring B-cell repopulation after depletion therapy in neurologic patients", Neurol Neuroimmunol Neuroinflamm, 5, pp.e463~ (2018)
  35. Li T, "Anti-Rituximab antibody in patients with NMOSDs treated with low dose Rituximab", J Neuroimmunol, 316, pp.107~111 (2018)
  36. Kim SH, "Individualized B cell-targeting therapy for neuromyelitis optica spectrum disorder", Neurochem Int, 130, pp.104347~ (2019)
  37. Avouac A, "rituximab-induced hypogammaglobulinemia and infections in AQP4 and MOG antibody-associated diseases", Neurol Neuroimmunol Neuroinflamm, 8 (2021)
  38. Marcinno A, "Rituximab-induced hypogammaglobulinemia in patients with neuromyelitis optica spectrum disorders", Neurol Neuroimmunol Neuroinflamm, 5, pp.e498~ (2018)
  39. Jeong IH, "Comparative analysis of treatment outcomes in patients with neuromyelitis optica spectrum disorder using multifaceted endpoints", Mult Scler, 22, pp.329~339 (2016)
  40. Torres J, "Analysis of the treatment of neuromyelitis optica", J Neurol Sci, 351, pp.31~35 (2015)
  41. Nikoo Z, "Comparison of the efficacy of azathioprine and rituximab in neuromyelitis optica spectrum disorder : a randomized clinical trial", J Neurol, 264, pp.2003~2009 (2017)
  42. Uzawa A, "Cytokine and chemokine profiles in neuromyelitis optica : significance of interleukin-6", Mult Scler, 16, pp.1443~1452 (2010)
  43. Matsushita T, "Characteristic cerebrospinal fluid cytokine", chemokine profiles in neuromyelitis optica, relapsing remitting or primary progressive multiple sclerosis, 2013, pp.8, e61835~
  44. Araki M, "Efficacy of the anti-IL-6 receptor antibody tocilizumab in neuromyelitis optica : a pilot study", Neurology, 82, pp.1302~1306 (2014)
  45. Ringelstein M, "Long-term therapy with interleukin 6 receptor blockade in highly active neuromyelitis optica spectrum disorder", JAMA Neurol, 72, pp.756~763 (2015)
  46. Zhang C, "Safety and efficacy of tocilizumab versus azathioprine in highly relapsing neuromyelitis optica spectrum disorder(TANGO) : an open-label, multicentre, randomised, phase 2 trial", Lancet Neurol, 19, pp.391~401 (2020)
  47. Weinstock-Guttman B, "Study of mitoxantrone for the treatment of recurrent neuromyelitis optica(Devic disease)", Arch Neurol, 63, pp.957~963 (2006)
  48. Kim SH, "Efficacy and safety of mitoxantrone in patients with highly relapsing neuromyelitis optica", Arch Neurol, 68, pp.473~479 (2011)
  49. Ramanathan RS, "Treatment of neuromyelitis optica", neuromyelitis optica spectrum disorders with methotrexate, 2014, pp.14, 51~
  50. Chen B, "Efficacy and safety of tacrolimus treatment for neuromyelitis optica spectrum disorder", Sci Rep, 7, pp.831~ (2017)
  51. Kageyama T, "Combination of cyclosporine a with corticosteroids is effective for the treatment of neuromyelitis optica", J Neurol, 260, pp.627~634 (2013)
  52. Min JH, "Development of extensive brain lesions following fingolimod(FTY720)treatment in a patient with neuromyelitis optica spectrum disorder", Mult Scler, 18, pp.113~115 (2012)
  53. Kim SH, "Does interferon beta treatment exacerbate neuromyelitis optica spectrum disorder?", Mult Scler, 18, pp.1480~1483 (2012)
  54. Ayzenberg I, "Efficacy of glatiramer acetate in neuromyelitis optica spectrum disorder : a multicenter retrospective study", J Neurol, 263, pp.575~582 (2016)
  55. Azzopardi L, "Alemtuzumab use in neuromyelitis optica spectrum disorders : a brief case series", J Neurol, 263, pp.25~29 (2016)
  56. Pittock SJ, "Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders : an open-label pilot study", Lancet Neurol, 12, pp.554~562 (2013)
  57. Pittock SJ, "Eculizumab in aquaporin-4-positive neuromyelitis optica spectrum disorder", N Engl J Med, 381, pp.614~625 (2019)
  58. Cree BAC, "Inebilizumab for the treatment of neuromyelitis optica spectrum disorder(N-MOmentum) : a double-blind, randomised placebo-controlled phase 2", 3 trial, 2019, pp.394, 1352~1363
  59. Traboulsee A, "Safety and efficacy of satralizumab monotherapy in neuromyelitis optica spectrum disorder : a randomised, double-blind, multicentre, placebo-controlled phase 3 trial", Lancet Neurol, 19, pp.402~412 (2020)
  60. Igawa T, "Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization", Nat Biotechnol, 28, pp.1203~1207 (2010)
  61. Yamamura T, "Trial of satralizumab in neuromyelitis optica spectrum disorder", N Engl J Med, 381, pp.2114~2124 (2019)

관련 논문AI추천

다발경화증과 시신경척수염범주질환의 감별진단김남희대한신경과학회 · 대한신경과학회지2016 · 제34권 제4호Monoclonal Antibody Therapies for Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder김우준, 김호진대한신경과학회 · Journal of Clinical Neurology2020 · 제16권 제3호Results of a Survey on Diagnostic Procedures and Treatment Choices for Neuromyelitis Optica Spectrum Disorder in Korea: Beyond the Context of Current Clinical Guidelines김병조, 김병준, 김수현, 김호진, 석진명, 이혜림대한신경과학회 · Journal of Clinical Neurology2022 · 제18권 제2호Evaluating Rituximab Failure Rates in Neuromyelitis Optica Spectrum Disorder: A Nationwide Real-World Study From South KoreaByeol-A Yoon, Eun Bin Cho, Eunhee Sohn, Eun-Jae Lee, Ha Young Shin, Ho Jin Kim, Hung Youl Seok, Jae-Won Hyun, Jeong Bin Bong, Jin Myoung Seok, Jong Kuk Kim, Jong Seok Bae, Ju-Hong Min, Ki Hoon Kim, Kyong Jin Shin, Min Su Park, Nam-Hee Kim, Ohyun Kwon, Sa-Yoon Kang, Seong-il Oh, Seung Ho Choo, Sohyeon Kim, Sooyoung Kim, Su-Hyun Kim, Suk-Won Ahn, Sukyoon Lee, Sung-Min Kim, Sunyoung Kim, Sun-Young Oh, Tai-Seung Nam, Woohee Ju, Yeon Hak Chung, Yoo Hwan Kim, Young-Min Lim, Young Nam Kwon, You-Ri Kang대한신경과학회 · Journal of Clinical Neurology2025 · 제21권 제2호New Insights into Neuromyelitis Optica김수현, 김우준, 김호진대한신경과학회 · Journal of Clinical Neurology2011 · 제7권 제3호Early relapse after rituximab treatment in a patient with seronegative neuromyelitis optica spectrum disorder: a case reportJu-Hee Lee, Yoon-Ho Hong대한임상신경생리학회 · Annals of Clinical Neurophysiology2024 · 제26권 제2호

이 간행물의 다른 논문 (19건)