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항Yo항체를 발현한 전립샘선암종 환자에서 발생한 척수염

Myelitis Presenting Anti-Yo Antibody in a Patient with Prostatic Adenocarcinoma

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초록

Antineuronal antibody-associated paraneoplastic neurologic syndromes result from tumor-stimulated autoimmune attacks against components of the nervous system. Paraneoplastic myelopathy associated with Purkinje-cell cytoplasmic autoantibody type 1 (anti-Yo) is extremely rare disorder. It is almost exclusively reported in women with gynecological tumors. Even though few cases of anti-Yo-associated paraneoplastic neurologic syndrome related to other cancers are reported, it is a very uncommon condition, especially in males. The author report here the first case of anti-Yo myelopathy with prostatic adenocarcinoma.

Abstract

Antineuronal antibody-associated paraneoplastic neurologic syndromes result from tumor-stimulated autoimmune attacks against components of the nervous system. Paraneoplastic myelopathy associated with Purkinje-cell cytoplasmic autoantibody type 1 (anti-Yo) is extremely rare disorder. It is almost exclusively reported in women with gynecological tumors. Even though few cases of anti-Yo-associated paraneoplastic neurologic syndrome related to other cancers are reported, it is a very uncommon condition, especially in males. The author report here the first case of anti-Yo myelopathy with prostatic adenocarcinoma.

참고문헌 (9)

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  5. Linnoila J, "Purkinje cell cytoplasmic antibody type I(anti-Yo) : predictive of gastrointestinal adenocarcinomas in men", J Neurol Neurosurg Psychiatry, 89, pp.1116~1117 (2018)
  6. Rosine N, "Expression of Yo antigen in a prostatic adenocarcinoma", Can J Neurol Sci, 44, pp.221~223 (2017)
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  8. 한승호, "항 Purkinje Cell 항체를 발현한 방종양성 변연계뇌염 1예", 대한신경과학회지, 23(5), pp.724~726 (2005), 대한신경과학회
  9. Peterson K, "Paraneoplastic cerebellar degeneration. I. A clinical analysis of 55 anti-Yo antibody-positive patients", Neurology, 42, pp.1931~1937 (1992)

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