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건강한 성인남녀의 혈청 γ-glutamyltransferase (γ-GT)와 혈청 페리틴과의 연관성

Relationship between Serum γ-glutamyltransferase Level and Serum Ferritin Level in Healthy Adults

김정하|이덕철|임지애|한아름|이혜리
대한가정의학회 (The Korean Academy Of Family Medicine)|2006.08|Korean Journal of Family Medicine|제27권 제8호|pp. 645-651

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참고문헌

키워드

oxidative stress산화스트레스γ-GT페리틴ferritin
주제분류가정의학

초록

연구배경: 혈청 γ-glutamyltransferase (γ-GT)는 글루타치온의 재합성과 관련된 효소로 최근에는 체내 산화스트레스의 지표로 알려져 있다. 여러 연구들에서 혈청 γ-GT는 심혈관계 질환 위험 요인들과 관련이 있으며 심혈관계 질환 사망률의 영향력 있는 예측인자로 보고되고 있다. 한편 혈청 페리틴은 산화스트레스를 증가 시키는 것으로 널리 알려져 있다. 따라서 혈청 페리틴은 γ-GT의 상승과 관련이 있을 수 있다. 이에 본 연구는 혈청 페리틴과 혈청 γ-GT의 연관성을 알아보고자 시행되었다. 방법: 건강한 성인 남녀 288명을 대상으로 혈청 γ-GT와 혈청 페리틴을 측정하였으며, 혈청 페리틴을 사분위로 나누어 혈청 γ-GT의 평균농도를 구한 후 분산 분석을 시행하여 차이를 알아보았다. 또한 혈청 γ-GT와 관련이 있는 변수들을 알아보기 위해 연령, 체질량지수, 수축기 혈압, 이완기 혈압, 중성지방, 총 콜레스테롤, 저밀도 지단백, 공복혈당, 고감도 C-단백, 혈청 페리틴, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), 요산 등을 독립변수로 하여 상관분석과 단계적 회귀 분석을 시행하였다. 결과: 혈청 γ-GT는 혈청 페리틴(r=0.42; P＜0.001)과 양의 상관관계를 보였으며, 혈청 페리틴의 농도가 상위 사분위로 갈수록 혈청 γ-GT 농도가 증가하였다. 혈청 γ-GT는 체질량지수, 중성지방, 총 콜레스테롤, 공복혈당, AST, ALT와 양의 상관관계를 보였으며, 단계적 회귀 분석에서 혈청 페리틴, ALT, 흡연, 중성지방이 혈청 γ-GT와 연관성을 보였다. 결론: 혈청 페리틴은 혈청 γ-GT의 상승과 관련된 요인이며, 이는 혈청 페리틴이 산화 스트레스를 매개로 하여 혈청 γ-GT의 상승에 관여됨을 시사한다.

Abstract

Relationship between Serum γ-glutamyltransferase Level and Serum Ferritin Level in Healthy AdultsJung Ha Kim, M.D., Hye Ree Lee, M.D., Ah Reum Han, M.D., Jee Aee Im, Ph.D.*, Duk Chul Lee, M.D., Ph.D.†

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