40세 이상 남성에서 산화적 스트레스의 지표로서 혈중 gamma-Glutamyltransferase와 소변중 8-hydroxydeoxyguanosine의 비교연구
Factors, Those are Related to Serum Gamma-Glutamyltransferase and Urine 8-hydroxydeoxyguanosine in Men Older Than 40 Years Old
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연구배경 혈중 GGT가 산화적 스트레스의 생물학적 지표로서 유용한지를 알아 보기위하여 소변중 8-OHdG와 혈중 GGT의 농도를 비교하였다. 방 법 2005, 1-4월, 검진 수진자중 40-70대 남성 186명을 대상으로 생활습관, 혈액검사 및 소변중 8-OHdG를 측정하였다. GGT, 8-OHdG 그리고 다른 변수들사이의 상관분석을 시행하고, GGT와 8-OHdG를 각각 두 군으로 구분하여 다른 변수들에서 유의한 차이가 있는지(t-test), GGT와 8-OHdG에 유의한 영향을 미치는 변수들을 구하였다(multiple regression). 결 과 평균연령은 50.78(±˙7.70)세, GGT와 8-OHdG는 39.45 (±36.36), 24.94(±74.51)으로 변이가 매우 컸다. GGT와 유의한 관련 변수는 나이, 혈압(수축기/이완기), 체지방, 중성지방, 총콜레스테롤, 요산, AFP, 음주이었고, 8-OHdG는 체지방, SGOT, 공복혈당. HbA1c, AFP, CEA, RA인자 이었다. 다중회귀분석 결과 AFP, TG, 요산이 GGT그리고 AFP, 공복혈당이 8-OHdG에 영향을 주었다(p<0.05). GGT와 8-OHdG는 관련성이 없었다(r=0.08, p>0.05). 결 론 GGT와 8-OHdG 사이에는 유의한 연관성이 없었으나 다른 심혈관계질환 위험인자들과는 유의한 연관성이 있었다(p<0.05). 혈중 GGT의 유용성 평가를 위해서는 더 이상의 연구가 필요하다.
Abstract
Background We studied factors, those are associated with serum GGT and urine 8-OHdG to assess the usefulness of serum GGT as a biomarker of oxidative stress. Methods January to April, 2005. 186 men, aged 40-70 years old, were participated. Including variables were 1) Health behavior 2) Blood tests 3) urine 8-OHdG. T-tests were done between low- and high-level group(GGT, 8-OHdG) Correlation test among log-transformed GGT, log-transformed 8-OHdG and other variables. Multiple regression analysis about GGT and 8-OHdG were done. Results Mean age(SD) is 50.78(7.70) years old. Both GGT and 8-OHdG were distributed right-skewed then log transformations were performed. Log GGT were correlated with age, BP, body fat%, TG, TC, Uric acid, AFP, Alcohol and log 8-OHdG with body fat%, SGOT, FBS, HbA1c, AFP, CEA, RA factor(p<0.05). Multiple regression analysis, log GGT was explained by AFP, TG, uric acid and log 8-OHdG by AFP, FBS (p<0.05). However, association between serum GGT and urine 8-OhdG was not significant(r=0.08, P>0.05). Conclusions Respectively, GGT and 8-OHdG were associated with risk factors of CVD but factors were not overlapped(except for AFP). Though serum GGT is reliable, easy and not expensive, more studies will be needed to assess the usefulness of GGT as a biomarker.
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