혈중 γ-GT와 고혈압
Serum γ-GT and Hypertensio
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연구배경: 이미 우리나라 남성을 대상으로 γ-GT의 상승과 고혈압의 연관성에 대해 대규모 연구가 진행되었으나, 남녀를 대상으로 하여 연구된 것은 없었다. 이에 저자들은 한 대학병원에서 실시하였던 건강검진 자료를 분석하여 혈중 γ-GT와 고혈압의 관련성을 알아보고자 하였다. 방법: 2004년 4월부터 2005년 4월까지 건강증진센터를 방문한 20세 이상 성인 남녀 중, B형 및 C형 간염 보유자와 간 기능에 영향을 줄 수 있는 약물을 복용하는 사람을 제외한 3,070명을 대상으로 하였다. 설문지와 문진을 통해 대상자들의 과거 병력과 현재 병력, 현재 복용 중인 약물에 대해 조사하였고, 기본적인 신체검사와 검사실 검사를 시행하였다. 결과: 혈중 γ-GT를 사분위수로 나누어 분류하였을 때, 남녀 모두에서 γ-GT의 분류단계가 올라갈수록 흡연, 음주, 체질량지수, 복부둘레, 수축기 및 이완기혈압, 공복혈당, 총콜레스테롤, 중성지방, 저밀도지질단백이 증가하였다(P for trend ＜0.01). γ-GT가 최고 사분위수에 해당하는 경우 최저 사분위수에 해당하는 경우에 비해 고혈압의 위험이 남성에서는 1.6배(95% CI, 1.0∼2.3), 여성에서는 1.6배(95% CI, 1.0∼2.4) 증가하였다. 결론: 이 연구에서는 심혈관계 질환에 영향을 미칠 수 있는 요인들을 통제하고도 남녀 모두에서 혈중 γ-GT가 최고 사분위수에 해당하는 경우 최저 사분위수에 해당하는 경우에 비해 고혈압의 위험이 증가하였다.
Abstract
Serum γ-GT and HypertensionSung-Sub Jung, M.D., Hee-Jeong Choi, M.D., Ph.D., Kyung- Hee Han, M.D., Sang-Hwan Kim, M.D., M.P.H.† Background: We analyzed the data obtained from regular health checkups performed in a university hospital and investigated the effect of serum γ-GT on hypertension for both Korean males and females. Methods: A total of 3,288 adult males and females over 20 years of age were selected for this study who visited a health promotion center from April, 2004 to April, 2005. Patients with HBs Ag (+) or anti-HCV Ab (+) and those currently on medication that could affect hepatic function were excluded. The subjects' history of illness and their present health and medication status were examined through questionnaires and history taking. Also, basic physical examinations and laboratory tests were performed on these subjects. Results: Classifying the serum γ-GT into quartiles, as the γ-GT classification stage increased, there was an increase in the amount of smoking, alcohol, body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, triglyceride and low density lipoprotein for males or female (respectively, P for trend ＜0.01). When odd ratio (95% CI) for hypertension in the highest quartile of γ-GT was compared to that of the lowest quartile, there was an increased risk of hypertension with an odd ratio of 1.6 (95% CI, 1.0∼2.3) and 1.6 (95% CI, 1.0∼2.4) for males and females, respectively. Conclusion: This study showed that the risk of hypertension was increased according to serum γ-GT, even though the variable index affecting cardiovascular diseases was adjusted. (J Korean Acad Fam Med 2007; 28:916-922)
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