건강검진 수진자에서 혈중 γ-glutamyltransferase와 염증지표와의 상관성
Association of γ-Glutamyltransferase and Inflammatory Markers in Health Screeners at a Health Promotion Center
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연구배경 죽상경화증의 발생에 낮은 수준의 염증이 중요한 역할을 하는 것으로 알려지면서 염증지표인 고민감도 C-반응성 단백(high-sensitive C-reactive protein, hsCRP)이 심혈관계 질환의 예측 인자로 제시되었다. 또한 γ-glutamyltransferase(GGT)가 산화 스트레스를 반영하며 hsCRP와 연관성이 있다는 보고가 있다. 이에 저자 등은 GGT와 염증지표인 hsCRP와의 상관성을 조사하였다. 방 법 2006년 6월부터 10월까지 부산의 일개 대학병원 건강증진센터를 방문한 1,618명을 대상으로 하였다. 혈청 GGT 농도에 따라 4분위수로 나누고 각 군에서 허리둘레, 체질량지수, 혈압, hsCRP에 대해 분산분석법으로 비교하였다. GGT와 loghsCRP 와의 상관관계는 부분상관계수를 이용하여 분석하였다. 결 과 체질량지수, 복부둘레, 수축기혈압 및 이완기혈압은 각 4분위수에서 모두 유의한 차이를 나타내었다. loghsCRP는 50 percentile미만인 군과 이상인 군에서 유의한 차이가 있었다. GGT는 loghsCRP (r=0.172, P<0.01)와 약하지만 유의한 양의 상관관계를 나타내었다. 지질성분 중에는 중성지방(r=0.431), 총콜레스테롤(r=0.221), 저밀도 지단백콜레스테롤(r=0.183)은 유의한 양의 상관관계, 고밀도 지단백콜레스테롤(r=-0.165)은 유의한 음의 상관관계가 있었다. 연령, 음주량, 체질량지수, 복부둘레, 수축기혈압 및 이완기혈압을 보정한 후 GGT와 loghsCRP(r=0.071, P=0.005)는 약하지만 유의한 양의 상관관계가 있었다. 결 론 본 연구에서 혈청 GGT 농도와 hsCRP 와는 통계적으로 유의한 상관관계를 보였지만 그 상관성은 낮아서 임상적으로 GGT와 염증지표간의 직접적인 연관성을 찾을 수는 없었다. 향후 GGT가 죽상경화증에 미치는 영향에 관한 전향적 연구가 필요하다.
Abstract
Background Low grade inflammation plays a major role in atherosclerosis, and the measurement of inflammatory markers such as high-sensitivity C-reactive protein (hsCRP) provide methods for risk prediction and reveal independent risk factors of cardiovascular diseases. Gamma-glutamyltransferase(GGT) may directly take part in atherogenesis and can be used potential biochemical risk indicator of cardiovascular disease. The purpose of our study was to assess the correlation between GGT and hsCRP concentration. Methods The study subjects consisted of 1,618 individuals who underwent periodic health examination in a university hospital in Busan from June to October 2006. Body mass index, abdominal circumference, blood pressure, and fasting glucose, lipid profile, general blood test, GGT and hsCRP were measured. To quantify the correlation between GGT and hsCRP concentration, partial correlation coefficient were presented. Results Total cholesterol(r=0.221, P<0.01), Triglyceride(r=0.431, P<0.01), loghsCRP(r=0.172, P<0.01) showed a significant correlation with GGT level. The GGT was significantly correlated with hsCRP level after adjusting for age, body mass index, abdominal circumference and blood pressure. Conclusions These finding suggest that there was a significant correlation between GGT and hsCRP concentration. Therefore, inflammatory status is higher in person who has high level of GGT than a person who has low level. The former is presumed to have a higher risk of atherosclerotic disease thereafter.
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