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자발적 휠 달리기를 포함한 enriched 환경이 streptozotocin에 의해 유발된 당뇨 쥐 해마의 신경세포생성과 단기기억력에 미치는 효과

Effects of enriched environment including voluntary wheel running on short？erm memory and neurogenesis in the hippocampal dentate gyrus of mice with streptozotocin？nduced diabetes

김유미|김창주|고일규|백성수|주광중
한국운동생리학회|2006.08|운동과학 (Exercise Science)|제15권 제3호|pp. 259-268

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short-term memory당뇨diabetesneurogenesis신경세포생성voluntary wheel running자발적 휠 달리기enriched 환경단기기억력enriched environment

초록

백성수, 김유미, 주관중, 고일규, 김창주. 자발적 휠 달리기를 포함한 enriched 환경이 streptozotocin에 의해 유발된 당뇨 쥐 해마의 신경세포생성과 단기기억력에 미치는 효과. 운동과학, 제15권 제3호. 259-268, 2006. 본 연구의 목적은 자발적 달리기를 포함한 enriched 환경이 streptozotocin(STZ)에 의해 유발된 당뇨 쥐 해마의 신경세포생성과 단기기억력에 미치는 영향을 알아보기 위하여 step-down avoidance 검사와 5-bromo-2'-deoxyuridine(BrdU) 면역조직화학법을 실시하였다. 8주령의 ICR 수컷 생쥐(n=50)를 대상으로 STZ를 주입하여 당뇨군을 만들었으며, 실험 집단은 정상군, 당뇨 통제군, 당뇨 자발적 휠 달리기군, 그리고 당뇨 자발적 휠 달리기를 포함한 enriched 환경군으로 구분하였다. 모든 생쥐에게 하루에 50mg/kg 의 BrdU를 4주간 복강에 투여하였으며, 단기 기억력을 측정하기 위한 행동검사를 실시하였다. 본 실험의 결과, 당뇨 통제군은 정상군에 비해 신경세포생성이 유의하게 감소하였으며, 당뇨 자발적 휠 달리기군과 당뇨 자발적 휠 달리기를 포함한 enriched 환경군에서 신경세포생성이 당뇨 통제군보다 유의하게 증가 하였다. 또한 단기 기억력 측정에서도 당뇨 통제군은 정상군에 비해 대기시간이 유의하게 감소하였으며, 당뇨 자발적 휠 달리기군과 당뇨 자발적 휠 달리기를 포함한 enriched 환경군에서 대기시간이 당뇨 통제군보다 증가하였다. 그 중 자발적 휠 달리기를 포함한 enriched 환경이 단기 기억력 회복에 더욱 효과적이였다. 본 실험을 통하여 자발적 휠 달리기를 포함한 enriched 환경은 당뇨에 의하여 감소된 신경세포생성을 증가시키고, 손상된 단기 기억력을 회복시킴으로써 당뇨에 의한 뇌기능 장애를 개선시킬 수 있을 것으로 사료된다.

Abstract

Baek, S.S., Kim, Y.M., Joo, K.J., Ko, I.G., Kim, C.J. Effects of enriched environment including voluntary wheel running on short-term memory and neurogenesis in the hippocampal dentate gyrus of mice with streptozotocin-induced diabetes. Exercise Science. 15(3): 259-268, 2006. Exposure to an enriched environment and physical activity, such as voluntary running, increases neurogenesis of granule cells in the dentate gyrus of mice. Diabetes mellitus is one of the most common metabolic disorders in humans. In the present study, the effects of enriched environment including voluntary wheel running on short-term memory and neurogenesis in the hippocampal dentate gyrus of the mice with streptozotocin(STZ)-induced diabetes was investigated via step-down avoidance task and 5-bromo- 2'-deoxyuridine(BrdU)-specific immunohistochemistry. Male IRC mice were randomly divided into the four groups: the control group, the STZ-induced diabetes group, STZ-induced diabetes with voluntary wheel running group, and the STZ-induced diabetes with enriched environment including voluntary wheel running group. The mice in all of the groups were intraperitoneally injected with 50 mg/kg BrdU once a day for 4 weeks. In the present results, the STZ-induced diabetic mice showed decreased neurogenesis in the hippocampal dentate gyrus, whereas exposure to enriched environment including voluntary wheel running increased neurogenesis in the STZ-induced diabetic mice. The latency in the STZ-induced diabetes group was shorter than the control group. Enriched environment including voluntary wheel running exceedingly delayed the latency of mice in the STZ-induced diabetic groups. Therefore, it can be suggested that enriched environment including voluntary wheel running may enhance brain function via increasing neurogenesis in the diabetic patients.

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