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Restraint stress suppresses hippocampal neurogenesis in adult female rats: reversal by exercise

김학렬|이삼준|김창주|천병옥
한국운동생리학회|2007.05|운동과학 (Exercise Science)|제16권 제2호|pp. 165-176

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참고문헌

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운동exercise해마hippocampusneurogenesis신경세포생성restraint stress구속-스트레스

초록

김창주, 천병옥, 김학렬, 이삼준. 스트레스는 해마의 신경세포생성을 억제 한다: 운동에 의한 반전. 운동과학, 제16권 제2호. 165-176, 2007. 본 연구의 목적은 구속-스트레스를 가한 암컷 쥐를 운동을 시킨 이후 스트레스로 인한 억제된 신경세포생성에 어떠한 영향을 미치는지를 검증하고자 하는데 있다. 해마에서의 신경세포생성의 확인은 세포주기의 S단계에서 세포분화의 지표를 나타내주는 BrdU를 통하여 확인이 가능하다. Sprague-Dawley계 흰쥐 암컷을 통제군, 구속-스트레스군, 구속-스트레스에 운동을 시킨 군, 운동군으로 4개의 집단으로 분류를 하였으며, 구속-스트레스에 노출을 시킨 후 즉시 운동을 시켰다. 뇌의 조직은 신경세포생성은 면역조직화학법으로 실시를 하였다. 연구의 결과는 구속-스트레스를 받은 쥐의 해마에서의 신경세포생성은 현저히 감소를 보였으며, 이러한 감소는 운동을 시킨 집단에서 유의하게 증가를 보이는 것으로 나타났다. 본 연구를 통하여, 규칙적인 운동 프로그램의 참가는 스트레스로 인한 항우울의 수단이 되며, 이러한 운동은 스트레스로 인한 신경세포생성의 억제를 향상시켜주는 것으로 감소한 신경세포의 활성을 증가시키는데 효과적인 요인이 될 수 있다고 사료된다.

Abstract

Kim, C.J., Chon, B.O., Kim, H.L., & Lee, S.J. Restraint stress suppresses hippocampal neurogenesis in adult rats: reversal by exercise. Exercise Science, 16(2): 165-176, 2007. The purpose of this study was to test whether the exercise decrease or increase neurogenesis on the hippocampal dentate gyrus in adult female rats from the restraint stress-induced treatment. Cell neurogenesis occurs in the dentate gyrus of the mammalian hippocampus throughout adult later life, and incorporation of bromodeoxyuridine (BrdU) into DNA can serve as a marker of cell division associated with such neurogenesis. We examined the effects of a restraint stressor (3 h once a day during 6 weeks) and exercise immediately following exposure of restraint stressed on hippocampal neurogenesis in SpragueDawley female rats. Animals were killed immediately following treatments (control group, restraint stress group, exercise plus restraint stress group, and exercise group, n= 10, respectively) and their brains were prepared for immunohistochemical studies. Restraint stress caused significant decreases in hippocampal neurogenesis indicating that the experienced stress was adverse effects for neurogenesis in hippocampal brain adult rats. The exercise treatment following the restraint procedure also caused a significant increase in BrdU labeling in the hippocampal dentate gyrus of SpragueDawley rats. Hippocampal cell neurogenesis appears to respond same to restraint stress plus exercise and exercise groups in adult female rats. Our finding may indicate that prolonged restraint stress is reversed by exercise following the stress-induced decreased neurogenesis.

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Effects of treadmill exercise on hippocampal cell proliferation and memory in streptozotocin rat model for sporadic Alzheimer's disease김창주, 윤진환, 이희혁, 정일규한국운동생리학회 · 운동과학2007 · 제16권 제1호트레드밀 운동이 외상성 뇌손상 흰쥐 해마에서 신경세포생성 및 BDNF 발현에 미치는 영향고일규, 김보균, 김성은, 김종오, 김창주, 서진희, 신말순, 윤진환, 이희혁, 정일규한국운동생리학회 · 운동과학2008 · 제17권 제3호트레드밀 운동이 헌팅턴병 유발 쥐의 뇌신경세포생성과 사멸 및 신경가소성에 미치는 영향김유미, 김창주, 김태운, 서태범, 윤진환, 지은상한국운동생리학회 · 운동과학2014 · 제23권 제2호자발 운동 및 부유 환경 조성에 의한 선조체 내 신경세포 생성 유도김은상, 민경훈, 박은숙, 박창일, 배병우, 임상희, 조성래대한재활의학회 · Annals of Rehabilitation Medicine2008 · 제32권 제6호반복적인 부동스트레스가 치아이랑 속분자층의 연접 가소성에 미치는 영향박찬, 김정혜, 문민호, 안희경, 윤미숙, 정주원, 허영범대한체질인류학회 · 해부·생물인류학2006 · 제19권 제4호트레드밀 운동이 추위 스트레스에 의한 생쥐 해마의 신경세포 사멸에 미치는 영향김기정, 김창주, 백성수, 이신호, 지은상한국운동생리학회 · 운동과학2009 · 제18권 제4호

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