걷기 운동이 비만 중년 여성의 인슐린 저항성에 미치는 영향
Effects of aerobic walking exercise on insulin resistance in obese middle-aged women. Exercise Science
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본 연구의 목적은 24주간의 유산소 걷기 운동 프로그램 참여가 비만 중년 여성의 인슐린 저항성과 인슐린 저항성 유발 기전일 것으로 판단되는 에너지 대사 조절 네트워크의 유전자 발현에 미치는 영향을 조사하는 것이었다. 연구의 대상자는 30-50세의 중년여성 총 32명으로 선정하였고 모든 피험자를 대상으로 BMI, 허리둘레, 경구당부하검사의 결과를 기준으로 정상 집단과 비만 인슐린 저항성 집단으로 구분하였다. 24주간의간 최대산소섭취량의 65% 수준에서 실시한 걷기 운동 프로그램에 따라 정상 집단과 비만 인슐린 저항성 집단에 상관없이 비만지표(체중, 체질량지수, 체지방율, 허리둘레)과 심폐체력 그리고 혈당의 항상성 조절 능력(Hba1c, MPG, FBG, FBI, HOMA-IR, AUC glucose)은 유의(p<.05)하게 개선되는 것으로 나타났다. 마지막으로 24주간의 유산소 운동 중재 프로그램은 정상 집단과 비만 인슐린 저항성 집단에 상관없이 복부피하지방의 에너지 대사 조절 네트워크 중 AMPK pathway와 mTOR pathway를 통계적으로 유의(p<.015, p<.008)하게 개선시키는 효과가 있는 것으로 밝혀졌으나, insulin pathway와 hexosamine pathway는 통계적으로 유의한 개선 효과는 없었지만 개선되는 경향을 보였다. 그러므로 24주간의간의 최대산소섭취량의 65%의 걷기 운동 프로그램은 두 집단에 상관없이 비만 지표와 인슐린 저항성 지표들을 개선시키고 비만으로 인한 인슐린 저항성 기전일 것으로 판단되는 에너지 대사 조절 네트워크를 개선시키는 것으로 나타났다.
Abstract
The purpose of this study was to investigate the effects of aerobic walking exercise on insulin resistance and energy metabolic regulatory networks in subcutaneous adipose tissues between non-obese(NO) and obese + insulin resistance(OI) groups. A total of 32 middle-aged women was classified as either NO group or OI group based on body mass index(BMI), waist circumference(WC), and oral glucose tolerance test, and they participated in a 24-week well-monitored exercise intervention program. Both of the NO and OI groups had significant(p<.05) improvements in obese indices (weight, BMI, BF, waist), CRF, insulin resistance indices(HbA1c, MPG, FBI, HOMA-IR, AUC glucose) following the 24-week exercise intervention program, with no significant group differences. With respect to mRNA expressions, both groups had significant(p<.05) improvements in AMPK pathway(AMPK) and mTOR pathway(mTOR), with no significant changes in insulin pathway(i.e., IRS, PDK, GLUT4), hexosamine pathway(GFAT), S6K, PPAR, JNK, and MAPKKK. In conclusion, the findings of the current study indicate that aerobic walking is an effective means of improving obesity and insulin resistance.
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