The AGTR2 (RS11091046) Gene Polymorphism is Associated with Cycling Performance in Korean Cyclists
0
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
PURPOSE: This study aimed to investigate the association between AGTR2 (rs11091046 A>C) gene polymorphism and athletic performance. METHODS: The Korean national team cyclists enrolled in the study performed 30-second Wingate test (peak power, mean power, and power drop), one-repetition maximum (squat and bench press), and isokinetic dynamometer (60° extensor and flexor in both legs) to examine the power/sprint performance between the C and A alleles. RESULTS: The physical characteristics showed no significant difference between the C and A alleles. Comparison of physical fitness tests in cyclists revealed no significant difference between the two alleles in one-repetition maximum and isokinetic dynamometer. However, the C allele had a significantly higher peak power (10.46±0.82 vs. 9.92±0.57, p=.016) and mean power (8.30±0.48 vs. 7.95±0.47, p=.022) than A allele in the Wingate test. CONCLUSIONS: Our results demonstrate that the AGTR2 gene C allele is associated with the power/sprint performance of the Korean national team cyclists.
Abstract
PURPOSE: This study aimed to investigate the association between AGTR2 (rs11091046 A>C) gene polymorphism and athletic performance. METHODS: The Korean national team cyclists enrolled in the study performed 30-second Wingate test (peak power, mean power, and power drop), one-repetition maximum (squat and bench press), and isokinetic dynamometer (60° extensor and flexor in both legs) to examine the power/sprint performance between the C and A alleles. RESULTS: The physical characteristics showed no significant difference between the C and A alleles. Comparison of physical fitness tests in cyclists revealed no significant difference between the two alleles in one-repetition maximum and isokinetic dynamometer. However, the C allele had a significantly higher peak power (10.46±0.82 vs. 9.92±0.57, p=.016) and mean power (8.30±0.48 vs. 7.95±0.47, p=.022) than A allele in the Wingate test. CONCLUSIONS: Our results demonstrate that the AGTR2 gene C allele is associated with the power/sprint performance of the Korean national team cyclists.
참고문헌 (15)
- Pedersen BK, "Muscles, exercise and obesity : skeletal muscle as a secretory organ", Nat Rev Endocrinol, 8(8), pp.457~465 (2012)
- Hausswirth C, "Endurance and strength training effects on physiological and muscular parameters during prolonged cycling", J Electromyogr Kinesiol, 20(2), pp.330~339 (2010)
- Ronnestad BR, "Strength training improves performance and pedaling characteristics in elite cyclists", Scand J Med Sci Sports, 25(1), pp.e89~e98 (2015)
- Faria EW, "The science of cycling : factors affecting performance-part 2", Sports Med, 35(4), pp.313~337 (2005)
- Bray MS, "The human gene map for performance and health-related fitness phenotypes : the 2006-2007 update", Med Sci Sports Exerc, 41(1), pp.35~73 (2009)
- Ahmetov, II, "Current progress in sports genomics", Adv Clin Chem, 70, pp.247~314 (2015)
- Fyhrquist F, "Renin-angiotensin system revisited", J Intern Med, 264(3), pp.224~236 (2008)
- Linderman JR, "Distribution of angiotensin II receptor expression in the microcirculation of striated muscle", Microcirculation, 8(4), pp.275~281 (2001)
- Mustafina LJ, "AGTR2 gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance", Exp. Physiol, 99(8), pp.1042~1052 (2014)
- Guilherme JPLF, "The AGTR2rs11091046(A>C)polymorphism and power athletic status in toplevel brazilian athletes", J Sports Sci, 36(20), pp.2327~2332 (2018)
- Yvert TP, "AGTR2 and sprint", power performance : a case-control replication study for rs11091046 polymorphism in two ethnicities, 2018, pp.35(2), 105~109
- Aoki S, "Genetic background in patients with acute myocardial infarction", Jpn Heart J, 42(1), pp.15~28 (2001)
- Jin JJ, "Association of angiotensin II type 2 receptor gene variant with hypertension", Hypertens Res, 26(7), pp.547~552 (2003)
- Sinkler SY, "Rapid versus slow ascending vasodilatation : intercellular conduction versus flow-mediated signalling with tetanic versus rhythmic muscle contractions", J Physiol, 595(23), pp.7149~7165 (2017)
- Lamb GD, "Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle", J Physiol, 589(9), pp.2119~2127 (2011)
