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한국인에서 무산소근파워와 ACE I/D 다형성간의 관계

Relationship of the ACE Insertion/Deletion Polymorphismto Short-Term Muscle Power in Korean Athletes

김철현
국민체육진흥공단 한국스포츠과학원 (Korea Institute of Sport Science)|2007.09|체육과학연구 (Korean Journal of Sport Science)|제18권 제3호|pp. 1-9|DOI 10.24985/kjss.2007.18.3.1

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performancepopulation geneticsACE polymorphism무산소성 근파워경기력관련 유전형ACE 다형성집단유전학Short-term muscle power
주제분류체육

초록

이 연구의 목적은 ACE I/D 다형성이 무산소근파워와 관련한 유전자인가를 구명(究明)하는 것이다. 연구목적을 위해 집단유전학의 사례-대조 연구법을 적용하였으며, 이 때 동원된 사례군은 무산소근파워 체력요인이 절대적으로 필요한 STMP(Short-term muscle power) 종목에 해당하는 육상 100m, 200m 단거리와 역도 종목의 우수선수 87명을 동원하였고, 대조군은 외관상 건강한 20대 30대 남녀 일반인 643명을 동원하여, ACE I/D 다형성을 비교․분석하였다. 연구결과 STMP 선수들의 ACE I/D 다형성 유전형 분포는 II 유전형이 42.5%, ID 유전형이 51.7%, DD 유전형이 5.7%로 대조군인 일반인의 II 유전형 31.7%, ID 유전형 51.6%, DD 유전형 16.7% 분포와는 유의한 차이를 가졌다(P<.05). STMP 선수들은 대조군에 비해 DD 유전형이 유의하게 낮았으며(P<.05), 반면 II + ID 유전형이 높은 분포율을 나타냈다(P<.05). 이를 근거로 무산소근파워 종목에 대한 성공 수준을 예측하고자 승산비를 구한 결과, II + ID 유전형이 DD 유전형 보다 평균 3.3배 및 최소 1.3배 수준의 성공 가능성을 가졌다(P<.01). 이 연구결과 한국인에서 ACE I/D 다형성은 II 유전형과 ID 유전형이 무산소근파워 능력의 잠재성을 높게 가지는 무산소근파워성 유전형인 것으로 나타났다.

Abstract

The D allele of the ACE I/D polymorphism is associated with elevated levels of serum and tissue ACE, increased production of angiotensin II. Several cardiac and renal conditions as well as skeletal muscle conditions appear to have a worse prognosis in subject homozygous for the D allele, whereas the I allele has been associated with enhanced performance. This study investigated the association between ACE I/D polymorphism and STMP(short-term muscle power) in 87 outstanding elite athletes (100m, 200m distance running, weight-lifting) and 643 healthy people. Distributions of the genotype of athletes are 42.5% of II genotype, 51.7% of ID genotype, and 5.7% of DD genotype, and different from that in controls which are 31.7%, 51.6%, 16.7% for II, ID, DD genotype respectively. The STMP significantly had 11.0% higher in II genotype than the control. The odds ratio associated with II+ID genotype was 3.3 time on average and ranged form 1.3 to 8.27 compared to DD genotype. In conclusion, in a geographically isolated homogenous population of Korea STMP athletes and healthy adults the presence of the DD genotype of the ACE gene conferred no increase in success in STMP sports, but the presence of the II genotype of the ACE gene suggested an increase in success in STMP sports

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