The Impacts of ACE Activity according to ACE I/D Polymorphisms on Muscular Functions of People Aged 65
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Objective To investigate associations between angiotensin-converting enzyme (ACE) polymorphisms and muscle fatigability in 65-year-old Koreans. Method The study participants were 49 Koreans aged 65 years. ACE insertion/deletion (I/D) polymorphisms were determined by polymerase chain reaction and serum ACE activity, by spectrophotometry. Body mass index (BMI), body fat mass (BFM), and lean body mass (LBM) were determined. To evaluate muscle fatigability, dynamic Electromyography was used to measure maximum voluntary isometric contractions (MVICs) of ankle plantar flexor muscles. Patients were seated with their hips flexed at 90°, knees fully extended, and ankles at 0°. Continuous submaximal VICs (40% MVIC) were then performed, and contraction duration and EMG frequency changes during the initial 2 min were measured. A self-reported physical activity questionnaire was used to evaluate effects of ACE activity levels on muscle fatigability.Results Among the 49 volunteers, 15 showed II genotype; 22, ID genotype; and 12, DD genotype. Serum ACE activity levels were significantly higher in DD genotype subjects than in II genotype subjects (p<0.05). Furthermore, the duration of submaximal isometric contractions was longer in II and ID genotype subjects than in DD genotype subjects (p<0.05). Dynamic EMG showed significantly lower mean frequency changes in II genotype subjects than in DD genotype subjects (p<0.05). However, LBM, BFM, and BMI were independent of ACE genotypes.Conclusion ACE II genotype subjects showed significantly higher resistant to muscle fatigue than that by DD genotype subjects. However, body composition and BMI showed no correlations with ACE I/D polymorphisms.
Abstract
Objective To investigate associations between angiotensin-converting enzyme (ACE) polymorphisms and muscle fatigability in 65-year-old Koreans. Method The study participants were 49 Koreans aged 65 years. ACE insertion/deletion (I/D) polymorphisms were determined by polymerase chain reaction and serum ACE activity, by spectrophotometry. Body mass index (BMI), body fat mass (BFM), and lean body mass (LBM) were determined. To evaluate muscle fatigability, dynamic Electromyography was used to measure maximum voluntary isometric contractions (MVICs) of ankle plantar flexor muscles. Patients were seated with their hips flexed at 90°, knees fully extended, and ankles at 0°. Continuous submaximal VICs (40% MVIC) were then performed, and contraction duration and EMG frequency changes during the initial 2 min were measured. A self-reported physical activity questionnaire was used to evaluate effects of ACE activity levels on muscle fatigability.Results Among the 49 volunteers, 15 showed II genotype; 22, ID genotype; and 12, DD genotype. Serum ACE activity levels were significantly higher in DD genotype subjects than in II genotype subjects (p<0.05). Furthermore, the duration of submaximal isometric contractions was longer in II and ID genotype subjects than in DD genotype subjects (p<0.05). Dynamic EMG showed significantly lower mean frequency changes in II genotype subjects than in DD genotype subjects (p<0.05). However, LBM, BFM, and BMI were independent of ACE genotypes.Conclusion ACE II genotype subjects showed significantly higher resistant to muscle fatigue than that by DD genotype subjects. However, body composition and BMI showed no correlations with ACE I/D polymorphisms.
참고문헌 (36)
- Rankinen T, "The human gene map for performance and health-related fitness phenotypes: the 2005 update", Med Sci Sports Exerc, 38, pp.1863~1888 (2006)
- Myerson SG, "Human angiotensin Iconverting enzyme gene and endurance performance", J Appl Physiol, 87, pp.1313~1316 (1999)
- Nazarov IB, "The angiotensin converting enzyme I", D polymorphism in Russian athletes, 2001, pp.9, 797~801
- Woods D, "Elite swimmers and the D allele of the ACE I", D polymorphism, 2001, pp.108, 230~232
- Vigano A, "Relationship between angiotensin-converting enzyme gene polymorphism and body composition, functional performance, and blood biomarkers in advanced cancer patients", Clin Cancer Res, 15, pp.2442~2447 (2009)
- Rigat B, "An insertion", deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels, 1990, pp.86, 1343~1346
- Dietze GJ, "Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis", J Renin Angiotensin Aldosterone Syst, 9, pp.75~88 (2008)
- Alvarez R, "Genetic variation in the renin-angiotensin system and athletic performance", Eur J Appl Physiol, 82, pp.117~120 (2000)
- Sanders PM, "Angiotensin II directly induces muscle protein catabolism through the ubiquitin-proteasome proteolytic pathway and may play a role in cancer cachexia", Br J Cancer, 22, pp.425~434 (2005)
- Greenlund LJ, "Sarcopenia-consequences, mechanisms, and potential therapies", Mech Ageing Dev, 124, pp.287~299 (2003)
- Nair KS, "Aging muscle", Am J Clin Nutr, 81, pp.953~963 (2005)
- Sumukadas D, "Sarcopenia- a potential target for Angiotensin-converting enzyme inhibition?", Gerontology, 52, pp.237~242 (2006)
- Basmajian JV, "Muscles alive-their functions revealed by electromyography, 5th ed", pp.201~220 (1985), Williams & Wilkins
- Ali A, "Analysis of insertion", deletion polymorphisms of the angiotensin converting enzyme gene in Malaysian end-stage renal disease patients, 2011, pp.18, 1~7
- Kasahara Y, "Colorimetry of angiotensin-l converting enzyme activity in serum", Clin Chem, 27, pp.1922~1925 (1981)
- Rantanen T, "Maximal isometric muscle strength and socioeconomic status, health, and physical activity in 75-year-old persons", J Aging Phys Act, 2, pp.206~220 (1994)
- Vandervoort AA, "Strength and endurance of skeletal muscle in the elderly", Physiotherapy Canada, 38, pp.167~173 (1986)
- Wilder RP, "Physical fitness assessment: an update", J Long Term Eff Med Implants, 16, pp.193~204 (2006)
- Nordez A, "Assessment of muscle hardness changes induced by a submaximal fatiguing isometric contraction", J Electromyogr Kinesiol, 19, pp.484~491 (2009)
- Hermens HJ, "Development of recommendations for SEMG sensors and sensor placement procedures", J Electromyogr Kinesiol, 10, pp.361~374 (2000)
- 전아영, "견봉하 마취제를 투여한 회전근개 파열 환자의 승모근과 삼각근의 활성도", Annals of Rehabilitation Medicine, 34(3), pp.316~324 (2010), 대한재활의학회
- Mademli L, "Behaviour of the human gastrocnemius muscle architecture during submaximal isometric fatigue", Eur J Appl Physiol, 94, pp.611~617 (2005)
- 최명애, "한국판 노인 신체활동 측정도구의 평가", 여성건강간호학회지, 16(1), pp.47~59 (2010), 여성건강간호학회
- Jones A, "Human performance: a role for the ACE genotype?", Exerc Sport Sci Rev, 30, pp.184~190 (2002)
- Frederiksen H, "Angiotensin I-converting enzyme (ACE) gene polymorphism in relation to physical performance, cognition and survival--a follow-up study of elderly Danish twins", Ann Epidemiol, 13, pp.57~65 (2003)
- Tobina T, "Relationship between angiotensin converting enzyme gene I", D polymorphism and muscle strength in elderly, 2006, pp.4, 460~464
- Laforest S, "Effects of age and regular exercise on muscle strength and endurance", Eur J Appl Physiol Occup Physiol, 60, pp.104~111 (1990)
- Ng JK, "Reliability of electromyographic power spectral analysis of back muscle endurance in healthy subjects", Arch Phys Med Rehabil, 77, pp.259~264 (1996)
- Edwards RH, "Human muscle function and fatigue", Ciba Found Symp, 82, pp.1~18 (1981)
- Tesch PA, "Influence of lactate accumulation of EMG frequency spectrum during repeated concentric contractions", Acta Physiol Scand, 119, pp.61~67 (1983)
- Mannion AF, "Electromyographic median frequency changes during isometric contraction of the back extensors to fatigue", Spine, 19, pp.1223~1229 (1994)
- Merletti R, "Myoelectric and mechanical manifestations of muscle fatigue in voluntary contractions", J Orthop Sports Phys Ther, 24, pp.342~353 (1996)
- Hagberg M., "Muscular endurance and surface electromyogram in isometric and dynamic exercise", J ApplPhysiol, 51, pp.1~7 (1981)
- Fuglevand AJ, "Impairment of neuromuscular propagation during human fatiguing contractions at submaximal forces", J Physiol, 460, pp.549~572 (1993)
- Garg A, "The effect of maximum voluntary contraction on endurance times for the shoulder girdle", International Journal of Industrial Ergonomics, 30, pp.103~113 (2002)
- Saris JJ, "Functional importance of angiotensinconverting enzyme-dependent in situ angiotensin II generation in the human forearm", Hypertension, 35, pp.764~768 (2000)