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聰明湯과 木槿皮聰明湯이 CT105와 βA로 유도된 Alzheimer's Disease 病態 모델에 미치는 영향

The Effects of ChongMyungTang(CMT) and ChongMyungTang added Hibiscus syriacus(MCMT) Extract on the Alzheimer's Disease Model Induced by CT-105 and βA

정인철|이상룡|박지운
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2006.03|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제17권 제1호|pp. 37-57

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Abstract

Objective : This research investigates the effect of the CMT and MCMT on Alzheimer's disease. Methods : The effects of the CMT and MCMT extract on (1) amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT-105; (2) the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of IL-1β, TNF-α, MDA, GFAP, CD68 abd CD11b; (5) the infarction area of the hippocampus in Alzheimer's diseased mice induced with βA were investigated. Results : 1. The CMT and MCMT extract suppressed the expression of APP, AChE, and mRNA in PC-12 cells treated with CT-105. 2. The CMT and MCMT extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 3. For the CMT and MCMT extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The CMT and MCMT extract suppressed the over-expression of IL-1β, TNF-α, MDA, GFAP, CD68 abd CD11bCD68/GFAP, in the mice with Alzheimer's disease induced by βA. 5. The CMT and MCMT extract reduced the infarction area of hippocampus with Alzheimer's disease induced by βA. 6. The MCMT showed more excellent effects than CMT in the every experiments except PC-12 cells. Conclusions : These results suggest that the CMT and MCMT extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the CMT and MCMT extract for Alzheimer's disease is suggested for future research.

참고문헌 (36)

  1. "東醫精神醫學", pp.256~271 (1992), 現代醫學書籍社
  2. "圖解腦神經外科學", pp.27~31 (1992), 第一醫學社
  3. "The E280A presenilin 1 Alzheimer mutation produces increased Aβ 42 deposition and severe cerebellar pathology.", 2(10), pp.1146~1150 (1996)
  4. "The importance of inflammatory mechanisms in Alzheimer disease", 33(5), pp.371~378 (1998)
  5. "Suppression of an amyloid beta peptide-mediated calcium channel response by a secreted beta-amyloid precursor protein", 95(1), pp.1~4 (2000)
  6. "Biochemical and neurobehavioral profile of CHF2819 orally active acetylcholinesterase inhibitor for Alzheimer's disease", 294(1), pp.187~194 (2000)
  7. "Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain", 101(1), pp.89~100 (2000)
  8. "Review of the acetylcholinesterase inhibitor galanthamine", 9(10), pp.2393~2402 (2000)
  9. "張氏景岳全書", pp.610~611 (1978), 翰成社
  10. "辨證奇問全書", pp.222~225 (1990), 甘地出版社
  11. "實用中醫內科學", pp.378~381 (1989), 上海科學技術出版社
  12. "漢藥臨床應用", pp.151~153 (1990), 成輔社
  13. "木槿皮가 CT-105로 유도된 Alzheimer's Disease 병태 모델에 미치는 영향" (2003)
  14. "New colorimetric cytotoxicity assay for anticancer drug screening", 82(13), pp.1107~1112 (1990)
  15. "Linearization of the Bradford protein assay increases its sensitivity ; theoretical and experimental studies.", 236(2), pp.302~308 (1996)
  16. "Automated flow cytometry for acquisition of time-dependent population data", 51a(2), pp.87~96 (2003)
  17. "Myocardial ischemia and reperfusion : a murine model", pp.2147~2154 (1995)
  18. "成人病 老人病學", pp.225~228 (1992), 고려의학
  19. "Toxic effect of the beta-amyloid precursor protein C-terminus fragment and Na+", Ca2+ gradients, 2000, pp.11(15), 3357~60
  20. "Gene transfer into the nervous system", 1(4), pp.339~71 (1987)
  21. "Mechanisms of amyloid beta protein-induced modification in ion transport systems implications for neurodegenerative diseases", 21(3), pp.173~213 (2001)
  22. "In vitro and in vivo studies investigating possible antioxidant actions of nicotine relevance to Parkinson's and Alzheimer's diseases", 1454(2), pp.143~152 (1999)
  23. "Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities", 60(2), pp.377~386 (1998)
  24. "Increased striatal dopamine efflux follows scopolamine administered systemically or to the tegmental pedunculopontine nucleus", 76(1), pp.177~186 (1997)
  25. "FcepsilonRII", CD23 is expressed in Parkinson's disease and induces production of nitric oxide and tumor necrosis factor-alpha in glial cells, 1999, pp.19(9), 3440~3447
  26. "The cerebrospinal fluid level of glial fibrillary acidic protein is increased in cerebrospinal fluid from Alzheimer's disease patients and correlates with severity of dementia", 46(1), pp.35~8 (2001)
  27. "精校黃帝內經素問", pp.217~218 (1985), 東洋醫學硏究院
  28. "中醫臨床大全", pp.224~230 (1991), 北京科學技術出版社
  29. "FR121196, a potential antidementia drug, ameliorates the impaired memory of rat in the Morris water maze", 272(1), pp.256~263 (1995)
  30. "Electrophysiological derngements induced by lipid peroxidation in cardiac tissue", 253, pp.1089~1097 (1987)
  31. "Lipid Peroxidation Damage to Cell Components" (1973)
  32. "Measuring free radical reaction in vivo", 49(3), pp.494~505 (1993)
  33. "In situ labeling of dying cortical neurons in normal aging and in Alzheimer‘s disease correlations with senile plaques and disease progression", pp.1134~42 (1996)
  34. "Increased poly(ADP-ribosyl) ation of nuclear proteins in Alzheimer's disease.", 122, pp.247~253 (1999)
  35. "TNF-alpha induced over-expression of GFAP is associated with MAPKs", 11(2), pp.409~412 (2000)
  36. "Microglia in the human fetal spinal cord--patterns of distribution", 115(1), pp.71~81 (1999)

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