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장원단이 CT105와 βA로 誘導된 Alzheimer's Disease 病態 모델에 미치는 影響

The Effects of JangWon-Dan,(JWD) on the Alzheimer's Disease Model Induced by CT-105 and βA

정대규|김건진
대한한방신경정신과학회 (The Korean Society Of Oriental Neuropsychiatry)|2006.07|동의신경정신과학회지 (The Korean Society of Oriental Neuropsychiatry)|제17권 제2호|pp. 91-122

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참고문헌

주제분류한의학

초록

Abstract

Objective :This research investigates the effect of the JangWon-Dan,(JWD) on Alzheimer's disease. Method :The effects of the JWN extract on (1) IL-1β, IL-6, and TNF-α mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA, the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of IL-1β, TNF-α, MDA, IL-1β mRNA, and TNF-α mRNA; (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with βA were investigated. Result :1. The JWN extract suppressed the expression of IL-1β, IL-6 and TNF-α mRNA in THP-1 cells treated with LPS.2. The JWN extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105.3. The JWN extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105.4. For the JWN extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The JWN extract suppressed the over-expression of IL-1β protein, TNF-α protein, MDA, IL-1β mRNA, TNF-α mRNA, and CD68/GFAP, in the mice with Alzheimer's disease induced by βA. 6. The JWN extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by βA. Conclusion : These results suggest that the JWN extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the JWN extract for Alzheimer's disease is suggested for future research.

참고문헌 (37)

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