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공진단이 CT105로 유도된 Alzheimer's disease 병태모델에 미치는 영향

The Effects of KongJin-Dan(KJD) on the Alzheimer's Disease Model Induced by CT105

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참고문헌

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Abstract

Abstract Objective : This experiment was designed to investigate the effect of KongJin-dan(KJD) on the Alzheimer's disease. Method : The effects of KJD on IL-1β, IL-6, TNF-α, amyloid precursor proteins(APP), acetylcholinesterase(AChE), glial fibrillary acidic protein(GFAP) mRNA of PC-12 and THP-1 cell treated by CT105 and AChE activity, APP production of PC-12 cell lysate treated by CT105 were investigated, respectively. Results : 1. KJD suppressed IL-1β, IL-6, TNF-α, APP, AChE, GFAP mRNA in THP-1 and PC-12 cell treated by CT105. 2. KJD suppressed AChE activity and production of APP significantly in cell lysate of PC-12 cell treated by CT105. Conclusions : This study shows that KJD might be usefully applied for prevention and treatment of Alzheimer's disease.

참고문헌 (43)

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