레바미졸이 틸라피아(Oreochromis niloticus)의 자연살해세포 활성에 미치는 영향
Effect of Levamisole on Enhancing Natural Cytotoxic Cell Activity in Nile Tilapia Oreochromis niloticus
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참고문헌
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초록
The study examined the effect of levamisole on the natural cytotoxic cell (NCC) activity of Nile tilapia (Oreochromis niloticus ) head kidney (HK) leukocytes. In vitro , HK leukocytes were incubated with 10-4 to 104 ng of levamisole/ml for 5, 20 or 40 h and then their NCC activity against target cells was assayed. The NCC activity appeared to increase after a 20 h of incubation. In vivo , tilapia were fed commercial diet containing 0, 50, 100 or 300 mg of levamisole/kg for 12 consecutive days. Then, the f ish were fed a commercial normal diet and samples harvested weekly 0 to 8 weeks after levamisole administration. The NCC activity was augmented uniformly at all times examined until the end of the experiment. In conclusion, levamisole effectively enhanced and maintained tilapia NCC activity.
Abstract
The study examined the effect of levamisole on the natural cytotoxic cell (NCC) activity of Nile tilapia (Oreochromis niloticus ) head kidney (HK) leukocytes. In vitro , HK leukocytes were incubated with 10-4 to 104 ng of levamisole/ml for 5, 20 or 40 h and then their NCC activity against target cells was assayed. The NCC activity appeared to increase after a 20 h of incubation. In vivo , tilapia were fed commercial diet containing 0, 50, 100 or 300 mg of levamisole/kg for 12 consecutive days. Then, the f ish were fed a commercial normal diet and samples harvested weekly 0 to 8 weeks after levamisole administration. The NCC activity was augmented uniformly at all times examined until the end of the experiment. In conclusion, levamisole effectively enhanced and maintained tilapia NCC activity.
참고문헌 (15)
- Anderson DP, "Immunostimulants, adjuvants, and vaccine carriers in f ish: applications to aquaculture", Ann Rev Fish Dis, 2, pp.281~307 (1992)
- Baba T, "Activation of mononuclear phagocyte function by levamisole immersion in carp", Nippon Suisan Gakkaishi, 59, pp.301~307 (1993)
- Cabaj W, "Levamisole and its influence on the immune response of lambs", Vet Res Commun, 19, pp.17~26 (1995)
- Cheng YC, "Leukoencephalopathy after levamisole for the treatment of verrucae", Acta Neurol Taiwan, 4, pp.262~266 (2011)
- Cuesta A, "Natural cytotoxic activity of giltheas seabream (Sparus aurata L) leucocytes. Assessment by f low cytometry and microscopy", Vet Immunol Immunopathol, 71, pp.161~171 (1999)
- Kajita Y, "The immunomodulatory effects of levamisole on rainbow trout, Oncorhynchus mikiss", Fish Pathol, 25, pp.93~98 (1990)
- Mulero V, "In vitro levamisole fails to increase seabream (Sparus aurata L) phagocyte functions", Fish Shellf ish Immunol, 8, pp.315~318 (1998)
- Mulero V, "Dietary intake of levamisole enhances the immune response and disease resistance of the marine teleost gilthead seabream (Sparus aurata L)", Fish Shellf ish Immunol, 8, pp.49~62 (1998)
- Olivier G, "Immunity to Aeromonas salmonicida in coho salmon (Oncorhynchus kisuthch ) induced by modif ied Freund's complete adjuvant: its non-specific nature and the probable role of macrophages in the phenomenon", Dev Comp Immunol, 9, pp.419~432 (1985)
- Renoux G, "The general immunopharmacology of levamisole", Drugs, 19, pp.89~99 (1980)
- Sakai M., "Current research status of f ish immunostimulants", Aquaculture, 172, pp.63~92 (1999)
- Siwicki AK, "Immunomodulating activity of levamisole in carp spawners, Cyprinus carpio", J Fish Biol, 31, pp.245~246 (1987)
- Siwicki AK., "Immunomodulating inf luence of levamisole on nonspecific immunity in carp (Cyprinus carpio )", Dev Comp Immunol, 13, pp.87~91 (1989)
- Siwicki AK, "In vitro immunostimulation on rainbow trout (Oncorhynchus mikiss ) spleen cells with levamisole", Dev Comp Immunol, 14, pp.231~237 (1990)
- Siwicki AK, "Effect of levamisole on the lymphocyte and macrophage activity in carp (Cyprinus carpio )", Ann Rech Vet, 21, pp.95~100 (1990)