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Potentials of Chenpi on Metabolic Syndrome: A Review

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Objectives: Metabolic Syndrome (MetS) is strongly related with central obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol (HDL-C), hyperglycemia, and hypertension. This study reviewed the potential of Chenpi in treatment of MetS through amelioration of co-related diseases, such as diabetes mellitus, hyperlipidemia, obesity, hepatic steatosis, and inflammation. Methods: Six electronic databases (Oriental Medicine Advanced Searching Integrated System (OASIS), Korean Traditional Knowledge Portal, Korea Institute of Oriental Medicine (KIOM), Research Information Sharing Service (RISS), PubMed, and Embase) were used to search for in vitro, in vivo, and clinical research that discusses the potential effects of Chenpi (Citrus unshiu Markovich, Citrus reticulata Blanco) on diabetes mellitus, hyperlipidemia, obesity, hepatic steatosis, and inflammation. Results: This review suggests the potential of Chenpi as a candidate for the treatment of metabolic syndrome through improvement of co-related diabetes, hyperlipidemia, obesity, hepatic steatosis, and inflammation. However, comparison of the results of each study was limited by a lack of quantification of the experimental materials.

Abstract

Objectives: Metabolic Syndrome (MetS) is strongly related with central obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol (HDL-C), hyperglycemia, and hypertension. This study reviewed the potential of Chenpi in treatment of MetS through amelioration of co-related diseases, such as diabetes mellitus, hyperlipidemia, obesity, hepatic steatosis, and inflammation. Methods: Six electronic databases (Oriental Medicine Advanced Searching Integrated System (OASIS), Korean Traditional Knowledge Portal, Korea Institute of Oriental Medicine (KIOM), Research Information Sharing Service (RISS), PubMed, and Embase) were used to search for in vitro, in vivo, and clinical research that discusses the potential effects of Chenpi (Citrus unshiu Markovich, Citrus reticulata Blanco) on diabetes mellitus, hyperlipidemia, obesity, hepatic steatosis, and inflammation. Results: This review suggests the potential of Chenpi as a candidate for the treatment of metabolic syndrome through improvement of co-related diabetes, hyperlipidemia, obesity, hepatic steatosis, and inflammation. However, comparison of the results of each study was limited by a lack of quantification of the experimental materials.

참고문헌 (94)

  1. Saklayen MG, "The Global Epidemic of the Metabolic Syndrome", Curr Hypertens Rep, 20(2), pp.12~ (2018)[DOI]
  2. Elaine W, "An in vitro and in vivo study of a 4-herb formula on the management of diet-induced metabolic syndrome", Phytomedicine, 42, pp.112~125 (2018)
  3. Lim S, "Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007", Diabetes care, 34(6), pp.1323~1328 (2011)[DOI]
  4. "National Health and Nutrition Survey. Prevalance of Metabolic Syndrome", ~ (2012)
  5. Kaur J, "A comprehensive review on metabolic syndrome", Cardiol Res Pract, 2014, pp.943162~ (2014)[DOI]
  6. Huang PL, "A comprehensive definition for metabolic syndrome", Disease models & mechanisms, 2(5-6), pp.231~237 (2009)[DOI]
  7. Grundy SM, "Metabolic Syndrome: A Multiplex Cardiovascular Risk Factor", The Journal of Clinical Endocrinology & Metabolism, 92(2), pp.399~404 (2007)[DOI]
  8. Cooney MT, "HDL cholesterol protects against cardiovascular disease in both genders, at all ages and at all levels of risk", Atherosclerosis, 206(2), pp.611~616 (2009)[DOI]
  9. Karr S, "Epidemiology and management of hyperlipidemia", Am J Manag Care, 23(9 Suppl), pp.S139~S148 (2017)
  10. Shah RV, "Statins and risk of new-onset diabetes mellitus", Circulation, 126(18), pp.e282~e284 (2012)[DOI]
  11. Haas AV, "Pathogenesis of Cardiovascular Disease in Diabetes", Endocrinol Metab Clin North Am, 47(1), pp.51~63 (2018)
  12. Wang GS, "Review of Biguanide (Metformin) Toxicity", Journal of intensive care medicine, 34(11-12), pp.863~876 (2019)[DOI]
  13. Babajafari S, "A review of the benefits of Satureja species on metabolic syndrome and their possible mechanisms of action", Journal of evidence-based complementary & alternative medicine, 20(3), pp.212~223 (2015)[DOI]
  14. Vahabzadeh M, "Effects of silymarin on metabolic syndrome: a review", Journal of the science of food and agriculture, 98(13), pp.4816~4823 (2018)[DOI]
  15. Razavi BM, "Saffron: a promising natural medicine in the treatment of metabolic syndrome", Journal of the science of food and agriculture, 97(6), pp.1679~1685 (2017)[DOI]
  16. Wang J, "Beneficial effects of ginger Zingiber officinale Roscoe on obesity and metabolic syndrome: a review", Annals of the New York Academy of Sciences, 1398(1), pp.83~98 (2017)[DOI]
  17. Ju Hyeong Lyu, "Effects of dried Citrus unshiu peels on gastrointestinal motility in rodents", Archives of Pharmacal Research, 36(5), pp.641~648 (2013), 대한약학회
  18. Lu Y, "Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China", Plant foods for human nutrition (Dordrecht, Netherlands), 61(2), pp.57~65 (2006)[DOI]
  19. Tejada S, "Potentials Anti-inflammatory Effects of Hesperidin from the Genus Citrus", Current medicinal chemistry, 25(37), pp.4929~4945 (2018)[DOI]
  20. Hajialyani M, "Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence", Molecules (Basel, Switzerland), 24(3), pp.648~ (2019)[DOI]
  21. Aggarwal V, "Molecular mechanisms of action of hesperidin in cancer:Recent trends and advancements", Experimental biology and medicine (Maywood, NJ), 245(5), pp.486~497 (2020)[DOI]
  22. Mas-Capdevila A, "Effect of Hesperidin on Cardiovascular Disease Risk Factors: The Role of Intestinal Microbiota on Hesperidin Bioavailability", Nutrients, 12(5), pp.1488~ (2020)[DOI]
  23. 최은식, "Effect of citri Unshiu Pericarpium and Citri Unshiu Pericarpium Immaturus on differentiation of pre-adipocyte", 석사, 한약학과, pp.2014
  24. Jo HK, "Anti-obesity Activities of Ethanol Extract of Citrus Peel in 3T3-L1 Preadipocytes", pp.2016
  25. Kim JN, "Effects of the herbal medicines on voltage-dependent K+ 2 channels", Pharmacognosy Magazine, 15(63), pp.369~377 (2019)
  26. 김수현, "陳皮의 항산화 활성 및 L6 근육세포에서 당대사에 미치는 영향", 대한본초학회지, 33(4), pp.101~114 (2018), 대한본초학회[DOI]
  27. 임희진, "Bioconversion of Citrus unshiu peel extracts with cytolase suppresses adipogenic activity in 3T3-L1 cells", Nutrition Research and Practice, 9(6), pp.599~605 (2015), 한국영양학회
  28. Park HS, "Effect of citrus unshiu peel extract fermented by Aspergillus niger on obesity and hyperglycemia in highfat diet fed C57BL", 6J mice, 서울대학교 대학원, 2017
  29. 윤영, "Inhibitory effects of Citrus unshiu pericarpium extracts on palmitate-induced lipotoxicity in HepG2 cells", Food Science and Biotechnology, 25(6), pp.1709~1717 (2016), 한국식품과학회[DOI]
  30. 조화은, "진피(Citri Pericarpium)를 섭취한 흰쥐의 지질대사 및 진피묵의 품질특성", 석사, 식품양생학과, pp.2014
  31. Iwata E, "Hypolipidemic and bifidogenic in the dietary fiber prepared from Mikan (Japanese mandarin orange: Citrus unshiu)albedo", Journal of nutritional science and vitaminology, 58(3), pp.175~180 (2012)[DOI]
  32. Soyoung Jung, "Anti-obesity effect of Citrus unshiu peel in rats fed a high-fat diet", 박사, Dept. of Science in Korean Medicine, pp.2013
  33. Lim DW, "Preventive effects of Citrus unshiu peel extracts on bone and lipid metabolism in OVX rats", Molecules (Basel, Switzerland), 19(1), pp.783~794 (2014)[DOI]
  34. 박창호, "고지방식이를 섭취한 흰쥐에서 진피 에탄올추출물이 혈청지질 및 체지방에 미치는 영향", Food Science and Preservation, 18(4), pp.567~574 (2011), 한국식품저장유통학회
  35. Park HJ, "Citrus unshiu peel extract ameliorates hyperglycemia and hepatic steatosis by altering inflammation and hepatic glucose- and lipidregulating enzymes in db", db mice, 2013, pp.24(2), 419~427
  36. Ke Z, "Citrus reticulata Blanco peel extract ameliorates hepatic steatosis, oxidative stress and inflammation in HF and MCD diet-induced NASH C57BL", 6 J mice, 2020, pp.83, 108426~
  37. Zeng W, "Nontargeted urine metabolomics analysis of the protective and therapeutic effects of Citri Reticulatae Chachiensis Pericarpium on high-fat feed-induced hyperlipidemia in rats", Biomedical chromatography : BMC, 34(4), pp.e4795~ (2020)[DOI]
  38. Kwak KH, "Antidiabetic Effect of Pericarpium Citri Reticulatae Extract", pp.2020
  39. 박치덕, "Aureobasidium pullulans를 이용한 진피 flavonoid의 생물전환 및 항비만 효능에 관한 연구", 박사, 생물학, pp.2011
  40. Kang SI, "Clinical Investigations of the Effect of Citrus unshiu Peel Pellet on Obesity and Lipid Profile", Evidence-based complementary and alternative medicine : eCAM, 2018, pp.4341961~ (2018)[DOI]
  41. 이진상, "혈중지질에 대한 진피추출물의 유효성 평가를 위한 인체적용시험:무작위배정, 이중맹검", 대한본초학회지, 26(1), pp.125~132 (2011), 대한본초학회
  42. Shaw JE, "Global estimates of the prevalence of diabetes for 2010 and 2030", Diabetes research and clinical practice, 87(1), pp.4~14 (2010)[DOI]
  43. Haidara M, "Evaluation of the possible contribution of antioxidants administration in metabolic syndrome", Current pharmaceutical design, 17(33), pp.3699~3712 (2011)[DOI]
  44. Atwater I, "Mouse pancreatic beta-cells: tetraethylammonium blockage of the potassium permeability increase induced by depolarization", The Journal of physiology, 288(1), pp.561~574 (1979)
  45. Henquin J, "9-aminoacridine -and tetraethylammonium-induced reduction of the potassium permeability in pancreatic B-cells:Effects on insulin release and electrical properties", Biochimica et Biophysica Acta (BBA)-General Subjects, 587(4), pp.579~592 (1979)
  46. Henquin JC, "Tetraethylammonium potentiation of insulin release and inhibition of rubidium efflux in pancreatic islets", Biochemical and biophysical research communications, 77(2), pp.551~556 (1977)
  47. MacDonald PE, "Inhibition of Kv2. 1 voltage-dependent K+ channels in pancreatic β-cells enhances glucose-dependent insulin secretion", Journal of Biological Chemistry, 277(47), pp.44938~44945 (2002)
  48. 김상미, "짚신나물 열수 추출물의 α-Glucosidase 저해 효과 및근육세포에서 포도당 이용에 미치는 영향", 한국식품영양학회지, 26(4), pp.806~813 (2013), 한국식품영양학회[DOI]
  49. 전서영, "세포 내 지방생성과 Glut-4 의존성 포도당 운반에 미치는 발효복합한약 물추출물(F-MAPC)의 영향", 대한본초학회지, 29(1), pp.45~52 (2014), 대한본초학회
  50. Valera A, "Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus", Proceedings of the National Academy of Sciences of the United States of America, 91(19), pp.9151~9154 (1994)[DOI]
  51. Tachibana S, "Octanoate reduces very low-density lipoprotein secretion by decreasing the synthesis of apolipoprotein B in primary cultures of chicken hepatocytes", Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1737(1), pp.36~43 (2005)[DOI]
  52. Dobiásová M, "The new atherogenic plasma index reflects the triglyceride and HDL-cholesterol ratio, the lipoprotein particle size and the cholesterol esterification rate: changes during lipanor therapy", Vnitrni lekarstvi, 46(3), pp.152~156 (2000)
  53. Fernández-Macías JC, "Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses", Archives of medical research, 50(5), pp.285~294 (2019)[DOI]
  54. Shen S, "Association between ideal cardiovascular health and the atherogenic index of plasma", Medicine, 95(24), pp.e3866~ (2016)[DOI]
  55. Dobiásová M, "The plasma parameter log (TG", HDL-C) as an atherogenic index:correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)), 2001, pp.34(7), 583~588
  56. Takahashi MM, "Metabolic syndrome and dietary components are associated with coronary artery disease risk score in free-living adults: a cross-sectional study", Diabetology & metabolic syndrome, 3, pp.7~ (2011)[DOI]
  57. Bok SH, "Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl -glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids", The Journal of nutrition, 129(6), pp.1182~1185 (1999)[DOI]
  58. Akpınar O, "A new index (CHOLINDEX) in detecting coronary artery disease risk", Anadolu kardiyoloji dergisi : AKD =the Anatolian journal of cardiology, 13(4), pp.315~319 (2013)[DOI]
  59. Oguejiofor OC, "Dyslipidemia in Nigeria: prevalence and pattern", Annals of African medicine, 11(4), pp.197~202 (2012)[DOI]
  60. Fang P, "Type 2 diabetes mellitus as a disorder of galanin resistance", Experimental Gerontology, 73, pp.72~77 (2016)[DOI]
  61. Seidell JC, "The Global Burden of Obesity and the Challenges of Prevention", Annals of Nutrition and Metabolism, 66(suppl 2), pp.7~12 (2015)[DOI]
  62. Obesity: preventing and managing the global epidemic, , WHO, 1~253, pp.World Health Organization technical report series 894 (2000)
  63. Koekemoer TC, "Isolation and characterization of adipose tissue glycerol -3-phosphate dehydrogenase", The international journal of biochemistry & cell biology, 27(6), pp.625~632 (1995)[DOI]
  64. Pairault J, "A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate dehydrogenase as differentiation marker", Proceedings of the National Academy of Sciences of the United States of America, 76(10), pp.5138~5142 (1979)[DOI]
  65. Swierczynski J, "Enhanced glycerol 3-phosphate dehydrogenase activity in adipose tissue of obese humans", Molecular and cellular biochemistry, 254(1-2), pp.55~59 (2003)[DOI]
  66. Matsuzawa Y, "Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease", Nature clinical practice Cardiovascular medicine, 3(1), pp.35~42 (2006)[DOI]
  67. Hui JM, "Beyond insulin resistance in NASH:TNF-alpha or adiponectin?", Hepatology (Baltimore, Md), 40(1), pp.46~54 (2004)[DOI]
  68. Xu A, "The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice", The Journal of clinical investigation, 112(1), pp.91~100 (2003)[DOI]
  69. Festuccia WT, "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake", American journal of physiology Regulatory, integrative and comparative physiology, 296(5), pp.R1327~R1335 (2009)[DOI]
  70. Yki-Järvinen H, "The fatty liver and insulin resistance", Current molecular medicine, 5(3), pp.287~295 (2005)[DOI]
  71. Brown MS, "Selective versus total insulin resistance: a pathogenic paradox", Cell metabolism, 7(2), pp.95~96 (2008)[DOI]
  72. Fracanzani AL, "Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes", Hepatology (Baltimore, Md), 48(3), pp.792~798 (2008)[DOI]
  73. Halim M, "The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes)", Diabetes & metabolic syndrome, 13(2), pp.1165~1172 (2019)[DOI]
  74. Karstoft K, "Exercise and type 2diabetes: focus on metabolism and inflammation", Immunology and cell biology, 94(2), pp.146~150 (2016)[DOI]
  75. Lontchi-Yimagou E, "Diabetes mellitus and inflammation", Current diabetes reports, 13(3), pp.435~444 (2013)[DOI]
  76. Pradhan AD, "Do atherosclerosis and type 2 diabetes share a common inflammatory basis?", European heart journal, 23(11), pp.831~834 (2002)[DOI]
  77. Cruz M, "Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2diabetes", Journal of endocrinological investigation, 31(8), pp.694~699 (2008)[DOI]
  78. Arababadi MK, "Nephropathic complication of type-2diabetes is following pattern of autoimmune diseases?", Diabetes research and clinical practice, 87(1), pp.33~37 (2010)[DOI]
  79. Kanda H, "MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity", The Journal of clinical investigation, 116(6), pp.1494~1505 (2006)[DOI]
  80. Nagao K, "Mukitake mushroom (Panellus serotinus) alleviates nonalcoholic fatty liver disease through the suppression of monocyte chemoattractant protein 1 production in db", db mice, 2010, pp.21(5), 418~423
  81. Xu H, "Elevated plasma concentration of IP-10 in patients with type 2 diabetes mellitus", Nihon Jinzo Gakkai shi, 47(5), pp.524~530 (2005)
  82. Esposito K, "Association of low interleukin-10 levels with the metabolic syndrome in obese women", The Journal of clinical endocrinology and metabolism, 88(3), pp.1055~1058 (2003)[DOI]
  83. van Exel E, "Low production capacity of interleukin-10 associates with the metabolic syndrome and type 2 diabetes : the Leiden 85-Plus Study", Diabetes, 51(4), pp.1088~1092 (2002)[DOI]
  84. "Chenpi" (2007)[URL]
  85. Kim HW, "Study on the Effects of Gamibojungikgi Tang on Ovarian Reaction and Pregnancy in Obesity Mice", The journal of orienetal gynecology (2000)
  86. Min BH, "The Effect of Gamiyukgunjatang on the Obesity in Rats", The journal of orienetal gynecology, 13(1), pp.469~484 (2000)
  87. 배인태, "六君子湯이 肥滿마우스의 體重 및 血淸含量變化에 미치는 영향", 동의생리병리학회지, 17(6), pp.1412~1418 (2003), 한의병리학회
  88. Kim IJ, "A case report of amenorrhea with obesity", Korean J. Korea Institue of Oriental Medical Informatics, 11(1), pp.47~51 (2005)
  89. Shin DG, "A Clinical Study on the Effects of Gwakhyangjunggi-san gamibang on 9 Obest Children", J Pediatr Korean Med, 15(1), pp.183~194 (2001)
  90. 김병주, "이중탕, 육군자탕, 보중익기탕의 이상지질혈증 및 고혈압과 관련된 일과성 수용체 전압 바닐로이드 4 이온통로 조절에 관한 연구", 한방비만학회지, 18(2), pp.57~63 (2018), 한방비만학회[DOI]
  91. 최정식, "消平湯이 Streptozotocin으로 유발된 당뇨쥐의 혈당 및 항산화 효소 활성에 미치는 영향", 대한한방내과학회지, 29(1), pp.90~103 (2008), 대한한방내과학회
  92. 주재홍, "六味地黃湯加味方이 streptozotocin으로 誘發된 白鼠의 實驗的 糖尿에 미치는 影響", 대한한의학 방제학회지, 14(2), pp.33~44 (2006), 대한한의학방제학회
  93. Lee E, "Saenggangeonbi-tang's Effect on Alcoholic Liver Cirrhosis-1 Case", J Korean Oriental Med, 21(3), pp.213~219 (2000)
  94. 최가혜, "韓方治療로 호전된 肥滿으로 인한 小兒의 脂肪肝 治驗 2例", 대한한방소아과학회지, 22(3), pp.95~103 (2008), 대한한방소아과학회

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