비알코올 지방간질환에 대한 한의학 연구 동향 보고: 국내 논문을 중심으로
A Review of Research Trends in Traditional Korean Medicine for Nonalcoholic Fatty Liver Disease
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: The aim of this study was to investigate the trends in research on non-alcoholic fatty liver disease (NAFLD) using Korean traditional medicine. Methods: This review included studies related to the treatment of NAFLD, irrespective of the year of publication. The search terms were “nonalcoholic fatty liver disease”, “non-alcoholic fatty liver”, “nonalcoholic hepatitis”, “herb”, “herbal medicine”, “acupuncture”, and “traditional medicine”. The studies were analyzed according to the type of research. Results: After screening, 179 studies were selected from the 592 identified by the search. The types of studies were 151 in vivo or in vitro studies, 5 randomized controlled trials, 12 case reports, 2 unspecified clinical studies, 8 review articles, and 1 article that was difficult to classify. Conclusion: Analysis of the trends in Korean traditional medicine treatment by reviewing the studies on NAFLD revealed a focus on experimental studies rather than clinical studies. Therefore, multifaceted and well-designed studies are needed.
Abstract
Objectives: The aim of this study was to investigate the trends in research on non-alcoholic fatty liver disease (NAFLD) using Korean traditional medicine. Methods: This review included studies related to the treatment of NAFLD, irrespective of the year of publication. The search terms were “nonalcoholic fatty liver disease”, “non-alcoholic fatty liver”, “nonalcoholic hepatitis”, “herb”, “herbal medicine”, “acupuncture”, and “traditional medicine”. The studies were analyzed according to the type of research. Results: After screening, 179 studies were selected from the 592 identified by the search. The types of studies were 151 in vivo or in vitro studies, 5 randomized controlled trials, 12 case reports, 2 unspecified clinical studies, 8 review articles, and 1 article that was difficult to classify. Conclusion: Analysis of the trends in Korean traditional medicine treatment by reviewing the studies on NAFLD revealed a focus on experimental studies rather than clinical studies. Therefore, multifaceted and well-designed studies are needed.
참고문헌 (142)
- 강성희, "KASL clinical practice guidelines: Management of nonalcoholic fatty liver disease", Clinical and Molecular Hepatology, 27(3), pp.363~401 (2021), 대한간학회
- Armandi A, "Natural history of NASH", Liver Int, 41(S1), pp.78~82 (2021)
- Estes C, "Modelling NAFLD disease burden in four Asian regions-2019-2030", Aliment Pharmacol Ther, 51(8), pp.801~811 (2020)
- Huang DQ, "Global epidemiology of NAFLD-related HCC : trends, predictions, risk factors and prevention", Nat Rev Gastroenterol Hepatol, 18(4), pp.223~238 (2021)
- Riazi K, "The prevalence and incidence of NAFLD worldwide : a systematic review and meta-analysis", Lancet Gastroenterol Hepatol, 7(9), pp.851~861 (2022)
- Im HJ, "Systematic review on the prevalence of nonalcoholic fatty liver disease in South Korea", Clinics and Research in Hepatology and Gastroenterology, 45(4), pp.101526~ (2021)
- 손창규, "Overview of RCT for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis", 대한한의학회지, 32(3), pp.44~49 (2011), 대한한의학회
- 현준, "비알코올성 지방간 질환에 대한 침치료의 효과 : 체계적 고찰", 대한한방내과학회지, 39(6), pp.1206~1224 (2018), 대한한방내과학회
- 김영광, "비알코올성 지방간질환의 利水 약재 포함 한약 치료에 대한 최신 임상 연구 동향 - CAJ 검색을 중심으로", 대한한방내과학회지, 40(1), pp.38~57 (2019), 대한한방내과학회[DOI]
- 이유리, "비알콜성 지방간질환의 한방치료에 대한 체계적 문헌고찰", 대한한방내과학회지, 40(1), pp.13~37 (2019), 대한한방내과학회[DOI]
- 최미영, "加味生肝湯이 고지방식이로 유발된 지방간에 미치는 영향", 대한한방내과학회지, 30(2), pp.365~374 (2009), 대한한방내과학회
- 유재연, "지방산으로 유발된 비알코올지방간질환 실험모델에 미치는 生肝湯加味方의 효과", 대한한방내과학회지, 31(2), pp.331~345 (2010), 대한한방내과학회
- 권수영, "Effects of Kamichunggantang on Lipoapoptosis and inflammation of NAFLD in db", db mice, 2017, pp.17(4), 365~372[DOI]
- 한창우, "Palmitate로 유발된 비알코올성 지방간 모델에 대한 KH淸肝湯의 효과 연구", 대한한의학회지, 32(1), pp.109~120 (2011), 대한한의학회
- Ji Taek Hong, "Effect of Korea red ginseng on nonalcoholic fatty liver disease: an association of gut microbiota with liver function", Journal of Ginseng Research, 45(2), pp.316~324 (2021), 고려인삼학회[DOI]
- 한병덕, "A Randomized, Double-Blind, Placebo-Controlled, Multi-Centered Clinical Study to Evaluate the Efficacy and Safety of Artemisia annua L. Extract for Improvement of Liver Function", Clinical Nutrition Research, 9(4), pp.258~270 (2020), 한국임상영양학회[DOI]
- Jeong JY, "New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease : A placebo-controlled, randomized, phase II trial", World J Gastroenterol, 23(32), pp.5977~5985 (2017)
- 홍미건, "Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease", Journal of Ginseng Research, 40(3), pp.203~210 (2016), 고려인삼학회
- 김대건, "황칠나무 추출물을 12주간 음용한 비알코올성지방간(NAFLD) 비만대학생들에게 미치는 영향", 한국엔터테인먼트산업학회논문지, 6(3), pp.142~146 (2012), 한국엔터테인먼트산업학회
- 김어진, "비만과 이상지질혈증을 동반한 비알코올 지방간질환 환자 치험 1례", 대한한방내과학회지, 43(2), pp.184~190 (2022), 대한한방내과학회[DOI]
- 권기현, "비알코올성 지방간 환자의 간기능 개선", 대한한방내과학회지, 41(5), pp.740~744 (2020), 대한한방내과학회[DOI]
- 손창규, "A juvenile case with nonalcoholic steatohepatitis and traditional Korean medicine-based treatment", Integrative Medicine Research, 7(2), pp.206~209 (2018), 한국한의학연구원[DOI]
- 김하연, "대사증후군을 동반한 비알코올성 지방간염 치험 1례", 대한한방내과학회지, 38(2), pp.125~130 (2017), 대한한방내과학회
- 백태현, "초음파 관찰을 통한 비알콜성 지방간 환자 치험 1례", 대한한의학회지, 37(1), pp.151~157 (2016), 대한한의학회
- 강경래, "피로감을 주증으로 입원한 청소년 비알코올성 지방간질환(NAFLD) 환자 치험 1례", 대한한방내과학회지, 37(5), pp.726~732 (2016), 대한한방내과학회
- 손창규, "A Case of Non-alcoholic Steatohepatitis Treated with Herbal Medicine", 대한한의학회지, 32(3), pp.50~54 (2011), 대한한의학회
- 박경선, "한방비만치료 후 초음파 영상에서 비알코올성 지방간의 호전을 보인 환자 치험 1례", 한방비만학회지, 9(1), pp.79~86 (2009), 한방비만학회
- 최가혜, "韓方治療로 호전된 肥滿으로 인한 小兒의 脂肪肝 治驗 2例", 대한한방소아과학회지, 22(3), pp.95~103 (2008), 대한한방소아과학회
- Heo JK, "A case study on a Non-alcoholic fatty liver disease(NAFLD)patient improved by the oriental obesity therapy program", J Korean Med Obes Res, 7(2), pp.85~94 (2007)
- 허진일, "한방비만치료를 통한 비알코올성 지방간염 의증 환자의 간기능 개선 1례 보고", 동의생리병리학회지, 20(6), pp.1785~1788 (2006), 한의병리학회
- Park SM, "A Case of Gagamsaenggan-tang’s Effect on Nonalcoholic Steatohepatitis", J of Oriental Chr Dis, 7(1), pp.73~77 (2001)
- Lee JH, "Hepatic steatosis index : A simple screening tool reflecting nonalcoholic fatty liver disease", Dig Liver Dis, 42(7), pp.503~508 (2010)
- 곽시라, "비알코올성지방간의 유관 인자 임상 연구: 종양표지자, 심박변이도, 사상체질", 사상체질의학회지, 31(2), pp.22~30 (2019), 사상체질의학회[DOI]
- Lee SK, "Non-alcoholic fatty liver disease among sasang constitutional types : a population-based study in Korea", BMC Complement Altern Med, 15(1), pp.399~ (2015)
- Choi ES, "Pharmacological Activities of Alisma orientale against Nonalcoholic Fatty Liver Disease and Metabolic Syndrome : Literature Review", Evid Based Complement Alternat Med, 2019, pp.1~15 (2019)
- 고흥, "비알콜성 지방간의 약물개발 중 茵蔯蒿湯의 타당성 연구", 동의생리병리학회지, 26(6), pp.823~833 (2012), 한의병리학회
- Sang Jun Yoon, "Effect of Korean red ginseng on metabolic syndrome", Journal of Ginseng Research, 45(3), pp.380~389 (2021), 고려인삼학회[DOI]
- 박연화, "비알콜성지방간의 유병율과 병리기전에 대한 문헌적 고찰", 대한한방내과학회지, 32(1), pp.26~32 (2011), 대한한방내과학회
- 김기태, "AHP 기법을 이용한 비알콜성 지방간에 茵蔯蒿湯 선택과정 분석", 대한한의진단학회지, 19(3), pp.159~171 (2015), 대한한의진단학회
- Choi SY, "Fermented Korean Red Ginseng Extract Enriched in Rd and Rg3 Protects against Non-Alcoholic Fatty Liver Disease through Regulation of mTORC1", Nutrients, 11(12), pp.2963~ (2019)
- Hwang YJ, "Pinus densiflora Sieb. et Zucc. Alleviates Lipogenesis and Oxidative Stress during Oleic Acid-Induced Steatosis in HepG2 Cells", Nutrients, 6(7), pp.2956~2972 (2014)
- Im HJ, "Ethyl Acetate Fraction of Amomum xanthioides Ameliorates Nonalcoholic Fatty Liver Disease in a High-Fat Diet Mouse Model", Nutrients, 12(8), pp.2433~ (2020)
- Jeon SH, "Beneficial Activities of Alisma orientale Extract in a Western Diet-Induced Murine Non-Alcoholic Steatohepatitis and Related Fibrosis Model via Regulation of the Hepatic Adiponectin and Farnesoid X Receptor Pathways", Nutrients, 14(3), pp.695~ (2022)
- Jung SW, "The Root of Polygonum multiflorum Thunb. Alleviates Non-Alcoholic Steatosis and Insulin Resistance in High Fat Diet-Fed Mice", Nutrients, 12(8), pp.2353~ (2020)
- Kim JH, "POCU1b, the n-Butanol Soluble Fraction of Polygoni Cuspidati Rhizoma et Radix, Attenuates Obesity, Non-Alcoholic Fatty Liver, and Insulin Resistance via Inhibitions of Pancreatic Lipase, cAMP-Dependent PDE Activity, AMPK Activation, and SOCS-3 Suppression", Nutrients, 12(12), pp.3612~ (2020)
- Kim YJ, "Platycodon grandiflorus Root Extract Attenuates Body Fat Mass, Hepatic Steatosis and Insulin Resistance through the Interplay between the Liver and Adipose Tissue", Nutrients, 8(9), pp.532~ (2016)
- Le TNH, "Ethanol Extract of Liriope platyphylla Root Attenuates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice via Regulation of Lipogenesis and Lipid Uptake", Nutrients, 13(10), pp.3338~ (2021)
- Lee GH, "Eucommia ulmoides Leaf Extract Ameliorates Steatosis Induced by High-fat Diet in Rats by Increasing Lysosomal Function", Nutrients, 11(2), pp.426~ (2019)
- Lee GH, "Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling", Nutrients, 12(3), pp.673~ (2020)
- Lee MR, "Leonurus japonicus Houtt Attenuates Nonalcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Cells and Mice Fed a High-Fat Diet", Nutrients, 10(1), pp.20~ (2017)
- Mun JE, "Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease", Nutrients, 11(10), pp.2536~ (2019)
- Park HY, "Hepatoprotective Effect of Herb Formula KIOM2012H against Nonalcoholic Fatty Liver Disease", Nutrients, 7(4), pp.2440~2455 (2015)
- Park M, "Lonicera caerulea Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2Hepatocytes and in High Fat Diet-Fed Mice", Nutrients, 11(3), pp.494~ (2019)
- Seo EH, "Psoralea corylifolia L. Seed Extract Attenuates Nonalcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice", Nutrients, 8(2), pp.83~ (2016)
- Song YO, "Sasa borealis Stem Extract Attenuates Hepatic Steatosis in High-Fat Diet-induced Obese Rats", Nutrients, 6(6), pp.2179~2195 (2014)
- Tran NKS, "Fermented Cordyceps militaris Extract Prevents Hepatosteatosis and Adipocyte Hypertrophy in High Fat Diet-Fed Mice", Nutrients, 11(5), pp.1015~ (2019)
- Chang BY, "Improvement in Menopause-Associated Hepatic Lipid Metabolic Disorders by Herbal Formula HPC03 on Ovariectomized Rats", Evid Based Complement Alternat Med, 2020, pp.1409376~ (2020)
- Choi DJ, "Protective Effect of a Mixture of Astragalus membranaceus and Lithospermum erythrorhizon Extract against Hepatic Steatosis in High Fat Diet-Induced Nonalcoholic Fatty Liver Disease Mice", Evid Based Complement Alternat Med, 2020, pp.1~11 (2020)
- Jung HY, "The Korean Mistletoe(Viscum album coloratum)Extract Has an Antiobesity Effect and Protects against Hepatic Steatosis in Mice with High-Fat Diet-Induced Obesity", Evid Based Complement Alternat Med, 2013, pp.1~9 (2013)
- Kim HG, "Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells", Evid Based Complement Alternat Med, 2017, pp.1~9 (2017)
- Lee YY, "Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue. Krishnan UM, editor", Evid Based Complement Alternat Med, 2020, pp.1~14 (2020)
- Lim DW, "Jwa Kum Whan Attenuates Nonalcoholic Fatty Liver Disease by Modulating Glucose Metabolism and the Insulin Signaling Pathway", Evid Based Complement Alternat Med, 2019, pp.1~10 (2019)
- Na HY, "Effect of Seyoeum on Obesity, Insulin Resistance, and Nonalcoholic Fatty Liver Disease of High-Fat Diet-Fed C57BL", 6 Mice, 2017, pp.2017, 1~8
- Yang DK, "Mulberry Fruit Extract Ameliorates Nonalcoholic Fatty Liver Disease(NAFLD)through Inhibition of Mitochondrial Oxidative Stress in Rats", Evid Based Complement Alternat Med, 2018, pp.1~9 (2018)
- Jang MK, "Schisandra chinensis extract ameliorates nonalcoholic fatty liver via inhibition of endoplasmic reticulum stress", J Ethnopharmacol, 185, pp.96~104 (2016)
- Jung HJ, "Ethanol extract of Pharbitis nil ameliorates liver fibrosis through regulation of the TGFβ1-SMAD2", 3 pathway, 2022, pp.294, 115370~
- Lim JH, "The polyherbal drug GGEx18from Laminaria japonica, Rheum palmatum, and Ephedra sinica inhibits hepatic steatosis and fibroinflammtion in high-fat diet-induced obese mice", J Ethnopharmacol, 225, pp.31~41 (2018)
- Park SH, "An unbiased lipidomics approach identifies key lipid molecules as potential therapeutic targets of Dohongsamul-tang against non-alcoholic fatty liver diseases in a mouse model of obesity", J Ethnopharmacol, 260, pp.112999~ (2020)
- Roh JS, "Effect of Gangjihwan on hepatic steatosis and inflammation in high fat diet-fed mice", J Ethnopharmacol, 206, pp.315~326 (2017)
- Seo MS, "Magnolia officinalis attenuates free fatty acid-induced lipogenesis via AMPK phosphorylation in hepatocytes", J Ethnopharmacol, 157, pp.140~148 (2014)
- Shin SS, "Korean red ginseng(Panax ginseng)inhibits obesity and improves lipid metabolism in high fat diet-fed castrated mice", J Ethnopharmacol, 210, pp.80~87 (2018)
- Bae UJ, "Gypenoside UL4-Rich Gynostemma pentaphyllum Extract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease", Am J Chin Med, 46(06), pp.1315~1332 (2018)
- Jeong HE, "Beneficial Effects of Korean Red Ginseng in the Progression of Non-Alcoholic Steatohepatitis via FABP4 Modulation", Am J Chin Med, 46(07), pp.1581~1607 (2018)
- Lee HY, "Rhus verniciflua and Eucommia ulmoides Protects Against High-Fat Diet-Induced Hepatic Steatosis by Enhancing Anti-Oxidation and AMPK Activation", Am J Chin Med, 47(06), pp.1253~1270 (2019)
- Lee MR, "Ixeris dentata Decreases ER Stress and Hepatic Lipid Accumulation through Regulation of ApoB Secretion", Am J Chin Med, 42(03), pp.639~649 (2014)
- Oh GS, "The Hexane Fraction of Cyperus rotundus Prevents Non-Alcoholic Fatty Liver Disease Through the Inhibition of Liver X Receptor ®-Mediated Activation of Sterol Regulatory Element Binding Protein-1c", Am J Chin Med, 43(03), pp.477~494 (2015)
- Hwang KA, "Extracts from Aralia elata(Miq)Seem alleviate hepatosteatosis via improving hepatic insulin sensitivity", BMC Complement Altern Med, 15(1), pp.347~ (2015)
- Jang EY, "Anti-lipoapoptotic effect of Artemisia capillaris extract on free fatty acids-induced HepG2 cells", BMC Complement Altern Med, 14(1), pp.253~ (2014)
- Lee MR, "Fermented mulberry(Morus alba)leaves suppress high fat diet-induced hepatic steatosis through amelioration of the inflammatory response and autophagy pathway", BMC Complement Med Ther, 20(1), pp.283~ (2020)
- Son YJ, "Yellow loosestrife (Lysimachia vulgaris var. davurica) ameliorates liver fibrosis in db", db mice with methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis, 2021, pp.21(1), 44~
- 최준용, "동과자 에탄올 추출물이 비알코올성 지방간 세포 모델에 미치는 효과", 대한한방내과학회지, 33(4), pp.438~447 (2012), 대한한방내과학회
- 한창우, "비알코올성 지방간 세포 모델에 대한 택사, 산사, 구기자, 울금, 단삼, 인진의 효능 비교", 대한한방내과학회지, 33(4), pp.533~542 (2012), 대한한방내과학회
- 김은영, "澤瀉가 유리지방산으로 유발된 HepG2 cell의 lipoapoptosis에 미치는 영향", 대한한방내과학회지, 35(2), pp.184~194 (2014), 대한한방내과학회
- 김소연, "비알코올성 지방간 세포 모델에서 곤포의 효능과 기전 연구", 대한한방내과학회지, 35(2), pp.175~183 (2014), 대한한방내과학회
- 이혜인, "곽향과 금전초 추출물이 Palmitic acid로 유발된 비알코올성 지방간 세포 모델에 미치는 영향", 대한한방내과학회지, 39(3), pp.302~312 (2018), 대한한방내과학회
- 이지원, "중만분소환 추출물이 Palmitate로 유발된 비알코올성 지방간 HepG2 cell 모델에 미치는 영향", 대한한방내과학회지, 37(3), pp.442~452 (2016), 대한한방내과학회
- 윤경수, "NASH 동물모델에서 인진청간탕과 인진사령산의 효과규명", 대한한방내과학회지, 30(2), pp.410~421 (2009), 대한한방내과학회
- 최은용, "Water Extract of Artemisia annua L. Exhibits Hepatoprotective Effects Through Improvement of Lipid Accumulation and Oxidative Stress-Induced Cytotoxicity", Journal of Medicinal Food, 23(12), pp.1312~1322 (2020), 한국식품영양과학회[DOI]
- 최지영, "Elucidation of the Metabolic and Transcriptional Responses of an Oriental Herbal Medicine, Bangpungtongseong-san, to Nonalcoholic Fatty Liver Disease in Diet-Induced Obese Mice", Journal of Medicinal Food, 22(9), pp.928~936 (2019), 한국식품영양과학회[DOI]
- 정민유, "Green Tea Lowers Hepatic COX-2 and Prostaglandin E2 in Rats with Dietary Fat-Induced Nonalcoholic Steatohepatitis", Journal of Medicinal Food, 18(6), pp.648~655 (2015), 한국식품영양과학회[DOI]
- 정윤희, "Aqueous Extract of Humulus japonicus Attenuates Hyperlipidemia and Fatty Liver in Obese Mice", Journal of Medicinal Food, 21(10), pp.999~1008 (2018), 한국식품영양과학회[DOI]
- Munkhtugs Davaatseren, "Dandelion Leaf Extract Protects Against Liver Injury Induced by Methionine- and Choline-Deficient Diet in Mice", Journal of Medicinal Food, 16(1), pp.26~33 (2013), 한국식품영양과학회[DOI]
- 임아랑, "Dolichos lablab Protects Against Nonalcoholic Fatty Liver Disease in Mice Fed High-Fat Diets", Journal of Medicinal Food, 20(12), pp.1222~1232 (2017), 한국식품영양과학회[DOI]
- 임아랑, "Water Extract of Dolichos lablab Attenuates Hepatic Lipid Accumulation in a Cellular Nonalcoholic Fatty Liver Disease Model", Journal of Medicinal Food, 19(5), pp.495~503 (2016), 한국식품영양과학회[DOI]
- 문정은, "Effects of Eriobotrya japonica Water Extract on Alcoholic and Nonalcoholic Fatty Liver Impairment", Journal of Medicinal Food, 22(12), pp.1262~1270 (2019), 한국식품영양과학회[DOI]
- 박기범, "Hovenia dulcis Extract Attenuates High-Fat Diet-Induced Hepatic Lipid Accumulation and Hypertriglyceridemia in C57BL", 6 Mice, 2019, pp.22(1), 74~80[DOI]
- 류리, "Ethanol Extract of Persimmon Tree Leaves Improves Blood Circulation and Lipid Metabolism in Rats Fed a High-Fat Diet", Journal of Medicinal Food, 18(7), pp.715~723 (2015), 한국식품영양과학회[DOI]
- Nguyen Khoi Song Tran, "Fermented Cordyceps militaris Extract Ameliorates Hepatosteatosis via Activation of Fatty Acid Oxidation", Journal of Medicinal Food, 22(4), pp.325~336 (2019), 한국식품영양과학회[DOI]
- 최나은, "Fermented ginseng, GBCK25, ameliorates steatosis and inflammation in nonalcoholic steatohepatitis model", Journal of Ginseng Research, 43(2), pp.196~208 (2019), 고려인삼학회[DOI]
- 김고운, "Ginseng seed oil ameliorates hepatic lipid accumulation in vitro and in vivo", Journal of Ginseng Research, 42(4), pp.419~428 (2018), 고려인삼학회[DOI]
- 김민희, "The involvement of ginseng berry extract in blood flow via regulation of blood coagulation in rats fed a high-fat diet", Journal of Ginseng Research, 41(2), pp.120~126 (2017), 고려인삼학회[DOI]
- Miey Park, "Ameliorative effects of black ginseng on nonalcoholic fatty liver disease in free fatty acid – induced HepG2 cells and high-fat", high-fructose diet-fed mice, 2020, pp.44(2), 350~361[DOI]
- Daram Yang, "Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis", Journal of Ginseng Research, 46(1), pp.126~137 (2022), 고려인삼학회[DOI]
- 안예지, "고지방식이 C57BL", 6N 모델에서 降脂丸의 농도별 비알콜성 지방간질환 개선효과, 2014, pp.29(2), 47~54[DOI]
- 황형칠, "비알콜성 지방간 동물모델에서 갈화추출물의 간보호 효과", 대한본초학회지, 33(5), pp.1~8 (2018), 대한본초학회[DOI]
- 김민철, "산사의 NAFLD 보호 효과 및 그 작용기전에 관한 연구", 대한본초학회지, 33(6), pp.61~70 (2018), 대한본초학회[DOI]
- 노종성, "고지방식이 유도 비알콜성지방간 마우스 모델에서 六神麯의 脂肪肝 개선효과", 대한본초학회지, 29(2), pp.23~31 (2014), 대한본초학회
- 신순식, "감비경신환(1)에 의한 고지방식이 비만동물모델에서 체중감량과 지질대사의 조절", 대한본초학회지, 29(1), pp.35~43 (2014), 대한본초학회
- 장두현, "고지방식이 비만마우스 모델에서 降脂丸과 降脂丸+加味消滯丸의 비알콜성 지방간질환 개선효과 비교", 대한한의학 방제학회지, 22(1), pp.167~176 (2014), 대한한의학방제학회
- 조주흠, "고지방식이 비만마우스 모델에서 파키스탄산 및 중국산 마황으로 조성된 降脂丸의 비알콜성 지방간질환 개선효과 비교", 대한한의학 방제학회지, 22(1), pp.113~122 (2014), 대한한의학방제학회
- 김재광, "간 실질세포주에서 泥胡菜 분획물이 liver X receptor α 의존적 지방 생성 유전자의 발현에 미치는 효과", 대한한의학 방제학회지, 28(3), pp.255~269 (2020), 대한한의학방제학회[DOI]
- 이혜인, "비알코올성 지방간 세포 모델에서 소분청음의 지방증 완화 효능 연구", 대한한의학 방제학회지, 24(2), pp.100~107 (2016), 대한한의학방제학회[DOI]
- 이주영, "三黃瀉心湯이 수컷 생쥐의 肥滿 관련 代謝疾患에 미치는 영향", 대한한의학 방제학회지, 22(1), pp.93~104 (2014), 대한한의학방제학회
- Kasper D, "Harrison’s Principles of Internal Medicine" (2017), MIP
- Hallsworth K, "Lifestyle modification in NAFLD", NASH : Facts and figures, 2019, pp.1(6), 468~479
- Langford CR, "Improved pathology reporting in NAFLD", NASH for clinical trials, 2022, pp.75(2), 73~75
- Li B, "Research Progress on the Mechanism of Acupuncture Treatment for Nonalcoholic Fatty Liver Disease. Zhao E, editor", Gastroenterol Res Pract, 2022, pp.1~8 (2022)
- Liang Z, "Efficacy and safety of traditional Chinese medicines for non-alcoholic fatty liver disease : a systematic literature review of randomized controlled trials", Chin Med, 16(1), pp.9~ (2021)
- Xu Y, "Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application", Front Pharmacol, 11, pp.601~ (2020)
- Shi KQ, "Traditional Chinese medicines benefit to nonalcoholic fatty liver disease : a systematic review and meta-analysis", Mol Biol Rep, 39(10), pp.9715~9722 (2012)
- Chen P, "The efficacy and safety of acupuncture in nonalcoholic fatty liver disease : A systematic review and meta-analysis of randomized controlled trials", Medicine, 100(38), pp.e27050~ (2021)
- Yan T, "Herbal drug discovery for the treatment of nonalcoholic fatty liver disease", Acta Pharmaceutica Sinica B, 10(1), pp.3~18 (2020)
- 백송영, "Ob", Ob 비만마우스 모델에서 降脂丸의 체중감량 효과, 2017, pp.25(2), 193~207[DOI]
- 이세나, "갱년기장애에 활용된 加味逍遙散의 문헌적 고찰", 대한한방부인과학회지, 22(4), pp.46~64 (2009), 대한한방부인과학회
- Clark JM, "Nonalcoholic fatty liver disease", Gastroenterology, 122(6), pp.1649~1657 (2002)
- GO HIROE, "Effects of three different formulae of Gamisoyosan on lipid accumulation induced by oleic acid in HepG2 cells", Integrative Medicine Research, 6(4), pp.395~403 (2017), 한국한의학연구원[DOI]
- Sang-hyun Ahn, "Herbal formulation MIT ameliorates high-fat diet-induced non-alcoholic fatty liver disease", Integrative Medicine Research, 9(4), pp.1~10 (2020), 한국한의학연구원[DOI]
- 김기봉, "마황, 인삼, 택사 복합추출물의 endocannabinoid system 억제를 통한 비알콜성 지방간 유도 인슐린저항성 개선 효과", 대한한방소아과학회지, 34(4), pp.11~21 (2020), 대한한방소아과학회[DOI]
- Goyale A, "Assessment of non-alcoholic fatty liver disease (NAFLD)severity with novel serum-based markers: A pilot study. Strnad P, editor", PLoS ONE, 16(11), pp.e0260313~ (2021)
- Diep Nguyen T, "Adiponectin : Role in physiology and pathophysiology", Int J Prev Med, 11(1), pp.136~ (2020)
- Woo HJ, "Oriental Internal Medicine on Hepatobiliary System, Hematology and Toxicology", pp.307~312 (2016), Nado
- 황수진, "生肝健脾湯이 알코올 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향", 대한본초학회지, 24(4), pp.9~15 (2009), 대한본초학회
- Lee IW, "Saeng-Kankunbi-Tang(生肝健脾汤)protects liver against oxidative damage through activation of ERK", Nrf2pathway, 2016, pp.22(8), 619~628
- Joung JY, "Anti-hepatofibrotic effects of CGX, a standardized herbal formula : A multicenter randomized clinical trial", Biomedicine & Pharmacotherapy, 126, pp.110105~ (2020)
- Kim HG, "CGX, a multiple herbal drug, improves cholestatic liver fibrosis in a bile duct ligation-induced rat model", Journal of Ethnopharmacology, 145(2), pp.653~662 (2013)
- Shin JW, "Scientific evaluation of the chronic toxicity of the herbal medicine CGX in beagle dogs", Food Chem Toxicol, 48(2), pp.743~749 (2010)
- Shin JW, "CGX, a traditional Korean medicine ameliorates concanavalin A-induced acute liver injury", Food Chem Toxicol, 48(12), pp.3308~3315 (2010)
- Kim HG, "Chunggan extract, a traditional herbal formula, ameliorated alcohol-induced hepatic injury in rat model", World J Gastroenterol, 20(42), pp.15703~15714 (2014)
- 송성민, "장침 전기자극 시술이 복부지방과 비만지표에 미치는 효과", 한방재활의학과학회지, 20(2), pp.113~127 (2010), 한방재활의학과학회
- Canbay A, "Non-invasive assessment of NAFLD as systemic disease-A machine learning perspective. Strnad P, editor", PLoS ONE, 14(3), pp.e0214436~ (2019)
- 김민지, "사상체질별 간기능 검사 및 초음파상의 간질환에 대한 연구", 사상체질의학회지, 25(3), pp.195~207 (2013), 사상체질의학회[DOI]
- Choi JY, "Efficacy and Safety of Human Pla-cental Extract for Alcoholic and Nonalcoholic Steatohepatitis : An Open-Label, Randomized, Comparative Study", Biological & Pharmaceutical Bulletin, 37(12), pp.1853~1859 (2014)
