대사이상 지방간질환 한약치료의 임상적 효과와 연구동향 : 체계적 문헌 고찰 및 메타분석
Herbal Medicine for Metabolic Dysfunction-Associated Steatotic Liver Disease : Clinical Effectiveness and Research Trends- A Systematic Review and Meta-Analysis
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Objective: This study systematically reviewed the effects of herbal medicine for metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: Fifteen randomized controlled trials involving patients with MASLD or non-alcoholic fatty liver disease (NAFLD) accompanied by cardiometabolic risk factors (CMRFs), published between January 2015 and June 2025, were identified from 10 databases. Meta-analysis focused primarily on clinical biochemical markers. Results: Type 2 diabetes mellitus (T2DM) and body mass index were the only factors of CMRFs that appeared during the search. T2DM studies showed a predominance of phlegm-blood stasis patterns. Herbal interventions targeting phlegm-blood stasis patterns increased in addition to existing traditional dampness-heat therapies. Meta-analysis of the studies reporting phlegm-blood stasis patterns in T2DM demonstrated significant improvements in biochemical markers and total effective rate with herbal medicine in combination with standard care. Conclusion: With the transition from NAFLD to MASLD, the Traditional Korean Medicine pathogenesis has expanded to include phlegm-blood stasis, suggesting broader therapeutic potential. Future research should involve rigorous MASLD-based criteria to improve homogeneity and reduce bias.
Abstract
Objective: This study systematically reviewed the effects of herbal medicine for metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: Fifteen randomized controlled trials involving patients with MASLD or non-alcoholic fatty liver disease (NAFLD) accompanied by cardiometabolic risk factors (CMRFs), published between January 2015 and June 2025, were identified from 10 databases. Meta-analysis focused primarily on clinical biochemical markers. Results: Type 2 diabetes mellitus (T2DM) and body mass index were the only factors of CMRFs that appeared during the search. T2DM studies showed a predominance of phlegm-blood stasis patterns. Herbal interventions targeting phlegm-blood stasis patterns increased in addition to existing traditional dampness-heat therapies. Meta-analysis of the studies reporting phlegm-blood stasis patterns in T2DM demonstrated significant improvements in biochemical markers and total effective rate with herbal medicine in combination with standard care. Conclusion: With the transition from NAFLD to MASLD, the Traditional Korean Medicine pathogenesis has expanded to include phlegm-blood stasis, suggesting broader therapeutic potential. Future research should involve rigorous MASLD-based criteria to improve homogeneity and reduce bias.