Herbal Medicine for the Treatment of Viral Hepatitis B and C: A Systematic Review of Randomized Controlled Trials
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) that applied herbal medicine to treat viral hepatitis B and C in order to determine the therapeutic efficacy of herbal medicine. EMBASE, Pubmed, NDSL, KMBASE, KISS, KISTI, Koreamed, Koreantk, and Oasis databases were searched to identify RCTs. The selected studies were assessed by the Cochrane group's risk of bias tool. A total of 15 RCTs were selected, and the hepatitis B virus (HBV) DNA reduction was significantly higher in patients treated with herbal medicine combined with Western medicine than in patients treated with herbal medicine. Herbal medicine combined with Western medicine was also superior to Western medicine alone in achieving hepatitis B e-antigen (HBeAg) and alanine aminotransferase [ALT] reduction. Only herbal medicine alone was not superior to Western medicine treatments in achieving HBV DNA, HBeAg, and ALT reduction.
Abstract
The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) that applied herbal medicine to treat viral hepatitis B and C in order to determine the therapeutic efficacy of herbal medicine. EMBASE, Pubmed, NDSL, KMBASE, KISS, KISTI, Koreamed, Koreantk, and Oasis databases were searched to identify RCTs. The selected studies were assessed by the Cochrane group's risk of bias tool. A total of 15 RCTs were selected, and the hepatitis B virus (HBV) DNA reduction was significantly higher in patients treated with herbal medicine combined with Western medicine than in patients treated with herbal medicine. Herbal medicine combined with Western medicine was also superior to Western medicine alone in achieving hepatitis B e-antigen (HBeAg) and alanine aminotransferase [ALT] reduction. Only herbal medicine alone was not superior to Western medicine treatments in achieving HBV DNA, HBeAg, and ALT reduction.
참고문헌 (32)
- Kasper DL, "Harrison's Principles of Internal Medicine", pp.2877~2896 (2017), McGraw-Hill Professional Publishing
- Decker A, "Viral hepatitis A-E", Internist (Berl), 62(2), pp.163~174 (2021)
- "Global Hepatitis Report, 2017" (2017)[URL]
- Almeida PH, "Update on the management and treatment of viral hepatitis", World J Gastroenterol, 27(23), pp.3249~3261 (2021)
- 정숙향, "C형 간염의 역학", 대한내과학회지, 88(6), pp.630~634 (2015), 대한내과학회[DOI]
- Richmond JA, "The use of complementary and alternative medicine by patients with chronic hepatitis C", Complement Ther Clin Pract, 16(3), pp.124~131 (2010)
- Jeongughanuigwadaehag gangyenaegwahaggyosil, "Gangyenaegwahag", pp.292~298 (2013), Nado
- Huang X, "Evaluation of PICO as a knowledge representation for clinical questions", AIMU Annu Symp Proc, 2006, pp.359~363 (2006)
- Kim SY, "NECA’s guidance for undertaking systematic reviews and meta-analyses for intervention", National Evidence-based Healthcare Collaborating Agency, 141~142 (2011)
- Batey RG, "Preliminary report of a randomized, double-blind placebo-controlled trial of a Chinese herbal medicine preparation CH-100 in the treatment of chronic hepatitis C", J Gastroenterol Hepatol, 13(3), pp.244~247 (1998)
- Chen C, "A randomized controlled trial of kurorinone versus interferon-α2a treatment in patients with chronic hepatitis B", J Viral Hepat, 7(3), pp.225~229 (2000)
- Chen ZX, "He Jie Tang in the treatment of chronic hepatitis B patients", World J Gastroenterol, 11(42), pp.6638~6643 (2005)
- Chen FP, "Clinical efficacy of Rong-Yang-Jyh-Gan-Tang on patients with chronic hepatitis C: A double-blinded randomized placebo-controlled crossover study", J Ethnopharmacol, 196, pp.1~8 (2007)
- He J, "Efficacy and safety of a Chinese herbal formula (invigorating kidney and strengthening spleen) in chronic hepatitis B virus carrier:Results from a multicenter, randomized, double -blind, and placebo-controlled trial", Evid Based Complement Alternat Med, 2013, pp.961926~ (2013)
- Lee CJ, "A Chinese medicine, Kuan-Sin-Yin decoction, improves liver function in hepatitis B virus carriers: A randomized, controlled study", J Altern Complement Med, 19(12), pp.964~973 (2013)
- Liu CY, "The Chinese medicine Kuan-Sin-Yin improves liver function in patients with chronic hepatitis C: A randomised and placebo-controlled trial", Complement Ther Med, 27, pp.114~122 (2016)
- Min L, "Modeling and simulating dynamics of completeand poor-response chronic hepatitis B Chinese patients for adefovir and traditional Chinese medicine plus adefovir therapy", Evid Based Complement Alternat Med, 2013, pp.767290~ (2013)
- Ye YA, "Effect of Shuanghu Qinggang ranule and Yigan Yiqi Jieyu granule plus lamivudine on chronic hepatitis B patients: A randomized double-blind placebo-controlled trial", Chin J Integr Med, pp.1~7 (2016)
- YongCai X, "Clinical effect of Dahyang Zhe Chong capsules combined with entecavir in treatment of chronic hepatitis B patients with liver fibrosis", J Clin Hepatol, 32, pp.1502~1507 (2016)
- Zhang CP, "Effects of Zhaoyangwanon chronic hepatitis B and posthepatic cirrhosis", World J Gastroenterol, 10(2), pp.295~298 (2004)
- Zhang SJ, "Effect of Hejie decoction on T cell immune state of chronic hepatitis B patients", World J Gastroenterol, 10(10), pp.1436~1439 (2004)
- Ye ZR, "Clinical analysis of modified Chaiping decoction in treating HBeAg -negative chronic hepatitis B", Zhongguo Zhong Yao Za Zhi, 41(20), pp.3875~3880 (2006)
- Zhou W, "Huju Yigan capsules combined with entecavir for treatment of patients with chronic hepatitis B: Clinical efficacy and influence on serum inflammatory factors", Shi Jie Hua Ren Xiao Hua Za Zhi, 25(20), pp.1882~1888 (2017)
- Zhu XJ, "Lingmao formula combined with entecavir for HBeAg-positive chronic hepatitis B patients with mildly elevated alanine aminotransferase:A multicenter, randomized, double-blind, placebo -controlled trial", Evid Based Complement Alternat Med, 2013, pp.620230~ (2013)
- Peters JL, "Comparison of Two Methods to Detect Publication Bias in Meta-analysis", JAMA, 295(6), pp.676~680 (2006)
- Wang J, "Meta-analysis of combination therapy of Chinese herbs plus interferon and ribavirin in patients with chronic hepatitis C", Med Sci Monit, 22, pp.1817~1826 (2016)
- Zhao S, "Interferon plus Chinese herbs are associated with higher sustained virological response than interferon alone in chronic Hepatitis C: A meta-analysis of randomised trials", Antiviral Res, 89(2), pp.156~164 (2011)
- Wang T, "Fuzheng Huayu capsule as an adjuvant treatment for HBV-related cirrhosis:A systematic review and meta-analysis", Phytother Res, 32(5), pp.757~768 (2018)
- Wei F, "Effect of Dahuang zhechong formula on liver fibrosis in patients with chronic hepatitis B: A metaanalysis", Complement Ther Med, 23(1), pp.129~138 (2015)
- Yang Y, "Chinese herbal medicine for carriers of the hepatitis B virus: An updated systematic review and meta-analysis", Pharmazie, 69(10), pp.723~753 (2014)
- Jeongughanuigwadaehag bonchohag gongdonggyojae -pyeonchanwiwonhoe, "Bonchohag", pp.584~586 (2011), Jeongseonsa
- The Korean Association for the Study of the Liver, "Chronic hepatitis B clinical practice guideline", pp.6~ (2015), Jin Publishing
