지각과 상엽 혼합추출물이 지질 개선에 미치는 영향
The Improvement of Mixed Extracts of Fructus Aurantii and Mulberry Leaves on Lipid Metabolism
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Background:Diabetes is a chronic disease characterized by deficiency of insulin. It has been reported that Fructus aurantii and mulberry leaves have the effect of anti-diabetes.Methods:To investigate the improvement of mixed extracts of Fructus aurantii and mulberry leaves on lipid metabolism, we performed double-blinded, randomized and placebo-controlled multi-center clinical trial. Results:Mixed extracts of Fructus aurantii and mulberry leaves significantly reduced total cholesterol.Conclusion:These results suggest that mixed extracts of Fructus aurantii and mulberry leaves improve lipid metabolism.
Abstract
Background:Diabetes is a chronic disease characterized by deficiency of insulin. It has been reported that Fructus aurantii and mulberry leaves have the effect of anti-diabetes.Methods:To investigate the improvement of mixed extracts of Fructus aurantii and mulberry leaves on lipid metabolism, we performed double-blinded, randomized and placebo-controlled multi-center clinical trial. Results:Mixed extracts of Fructus aurantii and mulberry leaves significantly reduced total cholesterol.Conclusion:These results suggest that mixed extracts of Fructus aurantii and mulberry leaves improve lipid metabolism.
참고문헌 (25)
- The Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus, "Report of the Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus", Diabetes Care, 26, pp.5~20 (2003)
- King H, "Global burden of diabetes, 1995-2025:prevalence, numerical estimates, and projections", Dia- betes Care, 21(9), pp.1414~1431 (1998)
- 통계청, "2006년 사망 및 사망원인통계결과", ~ (2007)
- UK Prospective Diabetes Study(UKPDS) Gr, "Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes:UKPDS 33", Lancet, 352, pp.837~853 (1998)
- UK Prospective Diabetes Study(UKPDS) Group, "Tight blood pressure control and risk of macrovascular complications in type 2 diabetes:UKPDS 38", BMJ, 317, pp.703~713 (1998)
- The Scandinavian Simvastatin Survival Study Group, "Randomized trial of chole- sterol lowering in 4444 patients with coronary heart disease:The Scandinavian Simvastatin Survival Study(4S)", Lancet, 344, pp.1383~1389 (1994)
- Klein R, "The Wisconsin Epidemiologic Study of Diabetic Retinopathy. III. Pre- valence and risk of diabetic retinopathy when age at diagnosis is 30 or more years", Arch Ophthalmol, 102, pp.527~532 (1984)
- American Diabetes Association, "Standards of Medical Care for Patients With Dia- betes Mellitus", Diabetes Care, 25, pp.33~49 (2002)
- American Diabetes Association, "Evidence- Based Nutrition Principles and Reco- mmendations for the Treatment and Pre- vention of Diabetes and Related Com- plications", Diabetes Care Diabetes Care, 25, pp.50~60 (2002)
- Li WL, "Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus", Journal of Ethnophar- macology, 92, pp.1~21 (2004)
- 안덕균, "한국본초도감", pp.462~ (1999), 교학사
- Huang YT, "Fructus aurantii reduced portal pressure in portal hyper- tensive rats", Life Sci, 57(22), pp.2011~2020 (1995)
- Jung UJ, "The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL", KsJ- db, Nutr, pp.2004, 134(10)[DOI]
- Jung UJ, "Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice.", Biochem Cell Biol, 38(7), pp.1134~1145 (2006)
- 안덕균, "한국본초도감", pp.602~603 (1999), 교학사
- 김소영, "Multiple low dose streptozotocin으로 유도된 고혈당 흰쥐에서 인삼, 상엽 단독 및 복합처방의 항당뇨효과", 약학회지 46권 6호, 41~415 (2002)
- Andallu B, "Antio- xidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin- diabetic rats", Clinica Chimica Acta, 338(1-2), pp.3~10 (2003)
- Andallu B, "Effect of mul- berry(Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes", Clinica Chimica Acta, 314(1-2), pp.47~53 (2001)
- 김호철, "한약약리학", pp.105~106 (2001), 집문당
- Kang MK, "Anti- diabetes effect of Mori Folium and Aurantii Fructus on diabetes rats in- duced by streptozotocin. 19th FAOBMB Seoul Conference", Science and Tech- nology for the Integration of Life, ~ (2007)
- The Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus, "Report of the Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus", Diabetes Care, 26, pp.5~20 (2003)
- The Scandinavian Simvastatin Survival Study Group, "Randomized trial of chole- sterol lowering in 4444 patients with coronary heart disease:The Scandinavian Simvastatin Survival Study(4S)", Lancet, 344, pp.1383~1389 (1994)
- Grundy SM, "Hypertriglyceridemia, insulin resistance, and the metabolic syndrome", Cardiol, 83, pp.25~29\ (1999)
- Reaven GM, "Insulin resistance and com- pensatory hyperinsulinemia:role in hyper- tension, dyslipidemia and coronary heart disease", Am Heart J, 121, pp.1283~1288 (1991)
- Saydah SH, "Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes", JAMA, 291, pp.335~342 (2004)
