본문 바로가기
KERD
논문KCI 등재

지각과 상엽 혼합추출물이 지질 개선에 미치는 영향

The Improvement of Mixed Extracts of Fructus Aurantii and Mulberry Leaves on Lipid Metabolism

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류한의학

초록

Background:Diabetes is a chronic disease characterized by deficiency of insulin. It has been reported that Fructus aurantii and mulberry leaves have the effect of anti-diabetes.Methods:To investigate the improvement of mixed extracts of Fructus aurantii and mulberry leaves on lipid metabolism, we performed double-blinded, randomized and placebo-controlled multi-center clinical trial. Results:Mixed extracts of Fructus aurantii and mulberry leaves significantly reduced total cholesterol.Conclusion:These results suggest that mixed extracts of Fructus aurantii and mulberry leaves improve lipid metabolism.

Abstract

Background:Diabetes is a chronic disease characterized by deficiency of insulin. It has been reported that Fructus aurantii and mulberry leaves have the effect of anti-diabetes.Methods:To investigate the improvement of mixed extracts of Fructus aurantii and mulberry leaves on lipid metabolism, we performed double-blinded, randomized and placebo-controlled multi-center clinical trial. Results:Mixed extracts of Fructus aurantii and mulberry leaves significantly reduced total cholesterol.Conclusion:These results suggest that mixed extracts of Fructus aurantii and mulberry leaves improve lipid metabolism.

참고문헌 (25)

  1. The Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus, "Report of the Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus", Diabetes Care, 26, pp.5~20 (2003)
  2. King H, "Global burden of diabetes, 1995-2025:prevalence, numerical estimates, and projections", Dia- betes Care, 21(9), pp.1414~1431 (1998)
  3. 통계청, "2006년 사망 및 사망원인통계결과", ~ (2007)
  4. UK Prospective Diabetes Study(UKPDS) Gr, "Intensive blood-glucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes:UKPDS 33", Lancet, 352, pp.837~853 (1998)
  5. UK Prospective Diabetes Study(UKPDS) Group, "Tight blood pressure control and risk of macrovascular complications in type 2 diabetes:UKPDS 38", BMJ, 317, pp.703~713 (1998)
  6. The Scandinavian Simvastatin Survival Study Group, "Randomized trial of chole- sterol lowering in 4444 patients with coronary heart disease:The Scandinavian Simvastatin Survival Study(4S)", Lancet, 344, pp.1383~1389 (1994)
  7. Klein R, "The Wisconsin Epidemiologic Study of Diabetic Retinopathy. III. Pre- valence and risk of diabetic retinopathy when age at diagnosis is 30 or more years", Arch Ophthalmol, 102, pp.527~532 (1984)
  8. American Diabetes Association, "Standards of Medical Care for Patients With Dia- betes Mellitus", Diabetes Care, 25, pp.33~49 (2002)
  9. American Diabetes Association, "Evidence- Based Nutrition Principles and Reco- mmendations for the Treatment and Pre- vention of Diabetes and Related Com- plications", Diabetes Care Diabetes Care, 25, pp.50~60 (2002)
  10. Li WL, "Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus", Journal of Ethnophar- macology, 92, pp.1~21 (2004)
  11. 안덕균, "한국본초도감", pp.462~ (1999), 교학사
  12. Huang YT, "Fructus aurantii reduced portal pressure in portal hyper- tensive rats", Life Sci, 57(22), pp.2011~2020 (1995)
  13. Jung UJ, "The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL", KsJ- db, Nutr, pp.2004, 134(10)[DOI]
  14. Jung UJ, "Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice.", Biochem Cell Biol, 38(7), pp.1134~1145 (2006)
  15. 안덕균, "한국본초도감", pp.602~603 (1999), 교학사
  16. 김소영, "Multiple low dose streptozotocin으로 유도된 고혈당 흰쥐에서 인삼, 상엽 단독 및 복합처방의 항당뇨효과", 약학회지 46권 6호, 41~415 (2002)
  17. Andallu B, "Antio- xidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin- diabetic rats", Clinica Chimica Acta, 338(1-2), pp.3~10 (2003)
  18. Andallu B, "Effect of mul- berry(Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes", Clinica Chimica Acta, 314(1-2), pp.47~53 (2001)
  19. 김호철, "한약약리학", pp.105~106 (2001), 집문당
  20. Kang MK, "Anti- diabetes effect of Mori Folium and Aurantii Fructus on diabetes rats in- duced by streptozotocin. 19th FAOBMB Seoul Conference", Science and Tech- nology for the Integration of Life, ~ (2007)
  21. The Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus, "Report of the Expert Commitee on the Diagnosis and Classification of Diabetes Mellitus", Diabetes Care, 26, pp.5~20 (2003)
  22. The Scandinavian Simvastatin Survival Study Group, "Randomized trial of chole- sterol lowering in 4444 patients with coronary heart disease:The Scandinavian Simvastatin Survival Study(4S)", Lancet, 344, pp.1383~1389 (1994)
  23. Grundy SM, "Hypertriglyceridemia, insulin resistance, and the metabolic syndrome", Cardiol, 83, pp.25~29\ (1999)
  24. Reaven GM, "Insulin resistance and com- pensatory hyperinsulinemia:role in hyper- tension, dyslipidemia and coronary heart disease", Am Heart J, 121, pp.1283~1288 (1991)
  25. Saydah SH, "Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes", JAMA, 291, pp.335~342 (2004)

관련 논문AI추천

이 간행물의 다른 논문 (10건)