본문 바로가기
KERD
논문KCI 등재

비알코올성 지방간질환의 利水 약재 포함 한약 치료에 대한 최신 임상 연구 동향 - CAJ 검색을 중심으로

Review of Clinical Research about Herbal Medicine Treatment containing Diuretic Herbs on Non-Alcoholic Fatty Liver Disease - Research on China Academic Journal

문영호|조명재|김영광
대한한방내과학회 (The Society Of Korean Oriental Internal Medicine)|2019.03|대한한방내과학회지 (The Journal of Korean Oriental Internal Medicine)|제40권 제1호|pp. 38-57|DOI https://doi.org/10.22246/jikm.2019.40.1.38

1

조회

0

다운로드

2

인용

0

참고문헌

키워드

traditional Chinese medicineCAJNAFLDherbal medicine treatmentdiutretic herbs
주제분류한의학

초록

Objective: This study reviewed recent clinical research trends regarding the effects of herbal medicine treatment containing diuretic herbs on nonalcoholic fatty liver disease (NAFLD) in China. Methods: We reviewed clinical studies on NAFLD from the China Academic Journal of the China National Knowledge Infrastructure from January 1, 2016, to September 10, 2018. Results: Thirty-nine papers from 86 studies were reviewed. The most commonly used herbal prescriptions included Alismatis Rhizoma (澤瀉), Salviae miltiorrhizae Radix (丹蔘), Crataegii Fructus (山査), Polia Sclerotium (茯苓), Bupleuri Radix (柴胡), and Cassiae Semen (決明子). The treatment effective rate, liver function test, serum lipid test, radiological examination, and symptom comparisons were used to analyze the treatments. In 32 of the papers, the effective treatment rate was 76.9%-100%, and the effectiveness in the experimental group was significantly higher than that in the control group (p<0.05). The risk ratio for the treatment effective rate was 1.26. The mean difference of ALT was -13.44 U/L (95% confidential interval, -24.45 U/L, -2.44 U/L, p=0.0166). Conclusion: Herbal medicine containing diuretic herbs has been demonstrated to be an effective and useful treatment for NAFLD. Clinical studies that are more scientific and systematic should be actively conducted in the future, and the results of the current study could be used as basic data in future clinical studies on herbal medicine treatment for NAFLD.

Abstract

Objective: This study reviewed recent clinical research trends regarding the effects of herbal medicine treatment containing diuretic herbs on nonalcoholic fatty liver disease (NAFLD) in China. Methods: We reviewed clinical studies on NAFLD from the China Academic Journal of the China National Knowledge Infrastructure from January 1, 2016, to September 10, 2018. Results: Thirty-nine papers from 86 studies were reviewed. The most commonly used herbal prescriptions included Alismatis Rhizoma (澤瀉), Salviae miltiorrhizae Radix (丹蔘), Crataegii Fructus (山査), Polia Sclerotium (茯苓), Bupleuri Radix (柴胡), and Cassiae Semen (決明子). The treatment effective rate, liver function test, serum lipid test, radiological examination, and symptom comparisons were used to analyze the treatments. In 32 of the papers, the effective treatment rate was 76.9%-100%, and the effectiveness in the experimental group was significantly higher than that in the control group (p<0.05). The risk ratio for the treatment effective rate was 1.26. The mean difference of ALT was -13.44 U/L (95% confidential interval, -24.45 U/L, -2.44 U/L, p=0.0166). Conclusion: Herbal medicine containing diuretic herbs has been demonstrated to be an effective and useful treatment for NAFLD. Clinical studies that are more scientific and systematic should be actively conducted in the future, and the results of the current study could be used as basic data in future clinical studies on herbal medicine treatment for NAFLD.

참고문헌 (72)

  1. Sourianarayanane A, "Management of non-alcoholic fatty liver disease", Minerva Gastroenterol Dietol, 59(1), pp.69~87 (2013)
  2. Masuoka HC, "Nonalcoholic fatty liver disease : an emerging threat to obese and diabetic individuals", Ann NY Acad Sci, 1281, pp.106~122 (2013)
  3. Fauci AS, "Harrison'principles of internal medicine", pp.1980~1983 (2008), McGraw-Hill
  4. Park SH, "Prevalence and risk factors of non-alcoholic fatty liver disease among Korean adults", J Gastroenterol Hepatol, 21, pp.138~143 (2006)
  5. Bae JC, "Impact of nonalcoholic fatty liver disease on insulin resistance in relation to HbA1c levels in nondiabetic subjects", Am J Gastroenterol, 105(11), pp.2389~2395 (2010)
  6. Choi SY, "The relation between non-alcoholic fatty liver disease and the risk of coronary heart disease in Koreans", Am J Gastroenterol, 104(8), pp.1953~1960 (2009)
  7. Argo CK, "Epidemiology and natural history of non-alcoholic steatohepatitis", Clinics in liver disease, 13(4), pp.511~531 (2009)
  8. Ibrahim MA, "Nonalcoholic fatty liver disease : current and potential therapies", Life Sci, 92(2), pp.114~118 (2013)
  9. 이혜인, "비알코올성 지방간 세포 모델에서 소분청음의 지방증 완화 효능 연구", 대한한의학 방제학회지, 24(2), pp.100~107 (2016), 대한한의학방제학회[DOI]
  10. 한창우, "Palmitate로 유발된 비알코올성 지방간 모델에 대한 KH淸肝湯의 효과 연구", 대한한의학회지, 32(1), pp.109~120 (2011), 대한한의학회
  11. 이지원, "중만분소환 추출물이 Palmitate로 유발된 비알코올성 지방간 HepG2 cell 모델에 미치는 영향", 대한한방내과학회지, 37(3), pp.442~452 (2016), 대한한방내과학회
  12. 김소연, "비알코올성 지방간 세포 모델에서 곤포의 효능과 기전 연구", 대한한방내과학회지, 35(2), pp.175~183 (2014), 대한한방내과학회
  13. 한창우, "비알코올성 지방간 세포 모델에 대한 택사, 산사, 구기자, 울금, 단삼, 인진의 효능 비교", 대한한방내과학회지, 33(4), pp.533~542 (2012), 대한한방내과학회
  14. 장영숙, "적소두가 비알코올성 지방간 질환 세포 모델에 미치는 효과", 동의생리병리학회지, 27(6), pp.802~809 (2013), 한의병리학회
  15. 최준용, "동과자 에탄올 추출물이 비알코올성 지방간 세포 모델에 미치는 효과", 대한한방내과학회지, 33(4), pp.438~447 (2012), 대한한방내과학회
  16. 이혜인, "곽향과 금전초 추출물이 Palmitic acid로 유발된 비알코올성 지방간 세포 모델에 미치는 영향", 대한한방내과학회지, 39(3), pp.302~312 (2018), 대한한방내과학회
  17. Traditional Chinese Association, "Guidelines for Diagnosis and Treatment of Common Internal Diseases in Chinese Medicine Diseases of Modern Medicine", pp.153~ (2008), China Traditional China Medicine Publisher
  18. Professors of Department of Internal Medicine of liver system, National College of Korean Medicine, "Gangye Naegwahak", pp.102~115 (2013), Nado
  19. 李 文科, "疏肝健脾 通络法治疗单纯非酒精性脂肪肝疗效观察", 临床合 理用药杂志, 11(22), pp.60~61 (2018)
  20. 李 润东, "益肝宝颗粒治疗非酒精性脂肪肝临床疗效观察", 中医临床研究, 10(15), pp.62~63 (2018)
  21. 马 军, "五苓散对非酒精性脂肪肝病患者血 清瘦素水平及胰岛素抵抗指数的影响", 光明中医, 33(16), pp.2389~2392 (2018)
  22. 莫 小艾, "受控衰减参数评估黄连 温胆汤治疗非酒精性脂肪肝湿热证疗效观察", 深圳 中西医结合杂志, 28(07), pp.44~46 (2018)
  23. 费 亚军, "温阳通络祛浊方治疗非酒精性脂肪 肝的疗效及对肝脾CT值的影响", 现代中西医结合 杂志, 27(24), pp.2699~2702 (2018)
  24. 时 晔, "畲药验方降脂保肝饮对非酒精性脂肪肝病痰 湿内阻证的疗效研究", 硕士, pp.2018
  25. 王 震, "五苓散加味方 治疗痰湿瘀阻型非酒精性脂肪肝疗效观察", 陕西中 医药大学学报, 41(04), pp.59~60 (2018)[DOI]
  26. 张 远杰, "自拟肝脂清膏方治疗非酒精性脂肪肝", 吉林中医药, 38(04), pp.413~416 (2018)
  27. 赵 嘉晶, "茵陈蒿 汤加减方对非酒精性脂肪肝患者糖, 脂及尿酸代 谢的影响", 四川中医, 36(03), pp.112~114 (2018)
  28. 周 烨威, "活血 降脂方治疗非酒精性脂肪肝的CT定量疗效评价", 现代中西医结合杂志, 27(09), pp.975~977 (2018)
  29. 崔 玉红, "二陈汤加味治疗非酒精性脂肪肝临床疗效 观察", 中医临床研究, 10(04), pp.59~60 (2018)
  30. 陶 杨, "速效降脂舒肝汤治疗非酒精性脂肪肝临床研究", 中医学报, 32(03), pp.444~448 (2017)
  31. 鲁 琳, "水飞蓟宾联合中药治疗非酒精性脂肪 肝24例疗效观察", 内蒙古中医药, 36(06), pp.27~ (2017)
  32. 鲁 恒心, "消脂清肝汤治疗非酒精性脂肪肝痰湿内阻 证临床研究", 中医学报, 32(12), pp.2477~2480 (2017)
  33. 李 萍, "自拟解郁疏肝汤治疗肝郁气滞型非 酒精性脂肪肝临床疗效及作用机制研究", 四川中医, 35(01), pp.94~96 (2017)
  34. 付 强, "温胆汤加减治疗单纯性非酒精性脂肪肝血脂 异常（痰湿质）的临床观察", 硕士, pp.2017
  35. 王 静, "软肝煎治疗非酒精性脂肪肝临床观察", 天津 中医药, 34(03), pp.168~169 (2017)
  36. 张 铁成, "调脂理肝汤治疗非酒精性脂肪肝 的临床观察", 内蒙古中医药, 36(Z1), pp.57~58 (2017)
  37. 周 烨威, "活血降脂方对非酒精性脂肪肝脂质代谢及肝功 能影响", 光明中医, 32(16), pp.2300~2302 (2017)
  38. 陈 延光, "茵芩清肝汤加减方对非酒精性脂肪肝患者 血清生化指标及中医症状积分的影响", 四川中医, 35(09), pp.66~68 (2017)
  39. 蔡 小旗, "加减二陈四物汤治疗非 酒精性脂肪肝124例临床观察", 世界中医药, 12(02), pp.285~288 (2017)
  40. 李 斌, "舒肝消癖颗粒治疗非酒精性脂肪肝的临床疗 效观察", 中医临床研究, 9(32), pp.48~49 (2017)
  41. 甘 小华, "活血化肝煎治 疗非酒精性脂肪肝痰瘀互结型临床研究", 光明中医, 31(20), pp.2923~2925 (2016)
  42. 贵 襄平, "枳术清脂汤治疗非酒精性脂肪肝42例临床观察", 中西医结合肝病杂志, 26(05), pp.300~301 (2016)
  43. 冀 晓利, "化痰降脂饮治疗非酒精性脂肪肝病的疗效 分析", 疾病监测与控制, 10(07), pp.547~549 (2016)
  44. 刘 启明, "活血降浊方治疗非酒精性脂肪肝病疗效观 察", 现代医药卫生, 32(09), pp.1385~1386 (2016)
  45. 马 红学, "健脾抑脂方治疗非酒精性脂肪肝40例临床疗效 观察", 中国民间疗法, 24(11), pp.42~43 (2016)
  46. 万 斌, "健脾疏肝活血方治疗非酒精性脂肪肝 的临床疗效观察", 陕西中医, 37(02), pp.135~138 (2016)
  47. 史 晓伟, "清肝祛湿活血 方治疗非酒精性脂肪肝的疗效评价", 中国实验方剂 学杂志, 22(15), pp.181~184 (2016)
  48. 徐 中菊, "丹芍疏肝 颗粒对不同中医证型非酒精性脂肪肝临床疗效研究", 辽宁中医杂志, 43(04), pp.771~773 (2016)
  49. 杨 倩, "柴胡 消脂方治疗气滞血瘀型非酒精性脂肪肝性肝病临 床研究", 四川中医, 34(03), pp.92~93 (2016)
  50. 阳 航, "清脂化瘀汤治疗非酒精性脂肪肝45例 疗效观察", 湖南中医杂志, 32(01), pp.41~43 (2016)
  51. 王 家华, "化浊清肝汤应用于非酒精性脂肪肝124例 临床疗效探讨", 现代诊断与治疗, 27(12), pp.2193~2194 (2016)
  52. 王 玉晓, "疏肝消脂方治疗非酒精性脂肪肝 31例", 河南中医, 36(05), pp.815~817 (2016)
  53. 王 田元, "自拟降脂护肝汤治疗非酒精性脂肪肝30例", 江西中医药, 47(06), pp.47~49 (2016)
  54. 张 悦, "健脾疏肝降脂方治疗非酒精性脂肪肝（肝郁 脾虚证）", 硕士, pp.2016
  55. 丁 海荣, "疏肝健脾疗法对非酒精性脂肪肝患者的 临床疗效观察", 硕士, pp.2016
  56. 周 毅, "复肝消脂汤治 疗非酒精性脂肪肝的临床观察", 中国中医药科技, 23(05), pp.577~578 (2016)
  57. 潘 孟, "降脂养肝汤治疗痰瘀互结型非酒精性 脂肪肝30例", 江西中医药大学学报, 28(03), pp.48~50 (2016)
  58. Li L, "Treatment of non-alcoholic fatty liver disease by Qianggan Capsule", Chin J Integr Med, 16(1), pp.23~27 (2010)
  59. Hasegawa T, "Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with nonalcoholic steatohepatitis : a pilot study", Aliment Pharmacol Ther, 15, pp.1667~1672 (2001)
  60. Harrison SA, "Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis", Am J Gastroenterol, 98(11), pp.2485~2490 (2003)
  61. National Cholesterol Education Program, "Second Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults(Adult Treatment Panel II)", Circulation, 89(3), pp.1333~1445 (1994)
  62. Li JJ, "Beneficial impact of Xuezhikang on cardiovascular events and mortality in elderly hypertensive patients with previous myocardial infarction from the China Coronary Secondary Prevention Study(CCSPS)", J Clin Pharmacol, 49(8), pp.947~956 (2009)
  63. Jia YJ, "Short-and long-term effects of xuezhikang, an extract of cholestin, on serum proprotein convertase subtilisin", kexin type 9 levels, 2016, pp.22(2), 96~100
  64. Al-Anati L, "Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupff er cells", Mol Nutr Food Res, 53(4), pp.460~466 (2009)
  65. Jayaraj R, "Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice", Environ Toxicol, 22(5), pp.472~479 (2007)
  66. Loguercio C, "Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease : a randomized controlled trial", Free Radical Bio Med, 52(9), pp.1658~1665 (2012)
  67. 장일웅, "택사(澤瀉)의 국내·외 연구동향과 『본초학』, 한국표준질병사인분류의 상관관계에 대한 연구", 대한본초학회지, 31(2), pp.47~62 (2016), 대한본초학회
  68. 박창훈, "丹蔘이 뇌조직출혈 흰쥐의 혈액뇌관문 손상에 미치는 영향", 대한본초학회지, 29(1), pp.19~26 (2014), 대한본초학회
  69. 김형철, "丹蔘이 고지혈증 흰쥐의 혈중 지질 변화에 미치는 영향", 대한본초학회지, 22(4), pp.239~245 (2007), 대한본초학회
  70. Lee SK, "Effect of CRATAEGII FRUCTUS(山査)on Sarum Lipid in High Cholesterol Diet Induced Hyperlipide Rats", Kor J Oriental Preventive Medical Society, 7(2), pp.13~22 (2003)
  71. 윤희진, "복령 추출물이 혈중 지질성상에 미치는 영향", 한국식품영양과학회지, 35(8), pp.1005~1009 (2006), 한국식품영양과학회
  72. The National College of Korean Medicine Herbal medicine textbook compilation committee, "Korean Herbal Medicine", pp.12~ (2012), Yeonglimsa

관련 논문AI추천

비알코올 지방간질환에 대한 한의학 연구 동향 보고: 국내 논문을 중심으로김경순, 김나연, 김상찬, 김승모, 윤미정, 최홍식대한한방내과학회 · 대한한방내과학회지2022 · 제43권 제4호대사이상 지방간질환 한약치료의 임상적 효과와 연구동향 : 체계적 문헌 고찰 및 메타분석공건식, 김소림, 김진현, 박수나, 서민조, 선민지, 이지원, 최요섭대한한방내과학회 · 대한한방내과학회지2025 · 제46권 제4호비알콜성 지방간질환의 한방치료에 대한 체계적 문헌고찰김경순, 김승모, 이유리, 조나경, 최홍식대한한방내과학회 · 대한한방내과학회지2019 · 제40권 제1호비알코올성 지방간 환자의 간기능 개선권기현, 김상범, 송금주, 신현수, 오서혜, 이형우대한한방내과학회 · 대한한방내과학회지2020 · 제41권 제5호비알코올성 지방간 질환에 대한 침치료의 효과 : 체계적 고찰현준, 김소연, 이주복, 한창우대한한방내과학회 · 대한한방내과학회지2018 · 제39권 제6호대사기능장애 연관 지방간질환(MASLD) 환자에 대한 마행감석탕 치험 1례서해니, 송호섭, 이은창대한한방내과학회 · 대한한방내과학회지2025 · 제46권 제4호

이 간행물의 다른 논문 (10건)

수컷 생쥐의 골다공증과 근위축에 대한 益智仁의 효과안상현, 박선영, 김형준pp. 1-12비알콜성 지방간질환의 한방치료에 대한 체계적 문헌고찰최홍식, 이유리, 조나경, 김경순, 김승모pp. 13-37한수대보원이 포유동물인 생쥐 모델에서 골 손실 및 RANKL 유도 파골세포 분화에 미치는 영향전찬용, 장시성, 류홍선, 황귀서pp. 58-69췌장암에 대한 국내 한의학 연구 동향 고찰 - 국내 한의학 논문을 중심으로 -김성수, 정하영, 박은주, 이아름, 이준명, 성신, 한가진pp. 70-88간암 한약제제 임상시험 가이드라인 개발을 위한 한약제제 무작위배정 대조군 임상시험 고찰임정태, 한가진, 김성수, 성신, 박은주, 김동훈pp. 89-116
원문 보기