본문 바로가기
KERD
논문KCI 등재

백서두개골 결손부에서 천연물유래 탄산칼슘염 골대체의 골치유에 관한 조직계측학적 평가

Histomorphometric evaluation of bone healing with natural calcium carbonate-derived bone substitutes in rat calvarial defect

2

조회

0

다운로드

1

인용

0

참고문헌

주제분류치의학

초록

Purpose: This study investigated the osteoconductivity of natural calcium carbonate-derived bone substitutes, hen eggshell (ES), and compared with those of commercial bone substitutes.Materials and Methods: Osseous defects created in the rat calvaria were filled with particulated ES(ES-1), ES with calcium-deficient hydroxyapatite surface layer (ES-2), Biocoral(Inoteb, France), and Bio-Oss(Geistlich Pharma, Wolhusen, Switzerland). After 4 and 8 weeks of healing, histomorphometic analysis was performed to evaluate the amount of newly formed mineralized bone area (NB%).Results: Histologic and histomorphometric analysis showed new bone formation and direct bony contact with the grafted materials in all groups. At 4 weeks, Biocoral group showed greater NB% compared to Bio-Oss and ES-1 groups (P<0.05). At 8 weeks, Biocoral and ES-2 groups showed significantly greater NB% compared to Bio-Oss group (P<0.05).Conclusion: These results indicate that natural calcium carbonate-derived bone substitutes with microporous calcium- deficient hydroxyapatite surface layer may be an effective materials treating osseous defects. (J Korean Acad Periodontol 2008;38:83-90)

Abstract

Purpose: This study investigated the osteoconductivity of natural calcium carbonate-derived bone substitutes, hen eggshell (ES), and compared with those of commercial bone substitutes.Materials and Methods: Osseous defects created in the rat calvaria were filled with particulated ES(ES-1), ES with calcium-deficient hydroxyapatite surface layer (ES-2), Biocoral(Inoteb, France), and Bio-Oss(Geistlich Pharma, Wolhusen, Switzerland). After 4 and 8 weeks of healing, histomorphometic analysis was performed to evaluate the amount of newly formed mineralized bone area (NB%).Results: Histologic and histomorphometric analysis showed new bone formation and direct bony contact with the grafted materials in all groups. At 4 weeks, Biocoral group showed greater NB% compared to Bio-Oss and ES-1 groups (P<0.05). At 8 weeks, Biocoral and ES-2 groups showed significantly greater NB% compared to Bio-Oss group (P<0.05).Conclusion: These results indicate that natural calcium carbonate-derived bone substitutes with microporous calcium- deficient hydroxyapatite surface layer may be an effective materials treating osseous defects. (J Korean Acad Periodontol 2008;38:83-90)

참고문헌 (35)

  1. Coughlin MJ, "Coralline hydroxyapatite bone graft substitute in hindfoot surgery", Foot Ankle Int, 27, pp.19~22 (2006)
  2. Velich N, "Lont-term results with different bone substitutes used for sinus floor elevation", J Craniofac Surg, 15, pp.38~41 (2004)
  3. Yukna RA, "A 5-year follow-up of 16 patients treated with coralline calcium carbonate (Biocoral) bone replacement grafts in infrabony defects", J Clin Periodontol, 25, pp.1036~1040 (1998)
  4. Guillemin G, "The use of coral as a bone graft substitute", J Biomed Mater Res, 21, pp.557~567 (1987)
  5. Artzi Z, "Porous bovine bone mineral in healing of human extraction sockets. Part 1: histomorphometric evaluations at 9 months", J Periodontol, 71, pp.1015~1023 (2000)
  6. Sculean A, "Clinical evaluation of an enamel matrix protein derivative (Emdogain) combines with a bovine-derived xenograft (Bio-Oss) for the treatment of intrabony periodontal defects in humans", Int J Periodontics Restorative Dent, 22, pp.259~267 (2002)
  7. Valentini P, "Maxillary sinus grafting with anorganic bovine bone: a clinical report of long-term results", Int J Oral Maxillofac Implants, 18, pp.556~560 (2003)
  8. Dupoirieux L, "Powdered eggshell: a pilot study on a new bone substitute for use in maxillofacial surgery", J Craniomaxillofac Surg, 23, pp.187~ (1995)
  9. Dupoirieux L, "Comparison of pericranium and eggshell as space fillers used in combination with guided bone regeneration: An experimental study", J Oral Maxillofac Surg, 58, pp.40~46 (2000)
  10. Dupoirieux L, "Resorption kinetics of eggshell: an in vivo study", J Craniofac Surg, 12, pp.53~58 (2001)
  11. Li F, "A simple biomimetic method for calcium phosphate coating", Surf Coat Technol, 154, pp.88~93 (2002)
  12. Choi JS, "Calcium phosphate coating of nickel-titanium shape-memory alloys. Coating procedure and adherence of leukocytes and platelets", Biomaterials, 24, pp.3689~3696 (2003)
  13. Tas AC, "Formation of apatitic calcium phosphates in a Na-K-phosphate solution of pH 7.4", J Mater Sci Mater Med, 16, pp.167~174 (2005)
  14. Vuola J, "Bone marrow induced osteogenesis in hydroxyapatite and calcium carbonate implants", Biomaterials, 17, pp.1761~1766 (1996)
  15. Hollinger JO, "The critical size defects as an experimental model to test bone repair materials", J Craniofac Surg, 2, pp.237~293 (1990)
  16. Schmitz JP, "The critical size defects as an experimental model for craniomandibular nonunions", Clin Orthop, 205, pp.299~308 (1986)
  17. Blom EJ, "Transforming growth factor β-1 incorporated in calcium phosphate cement stimulates osteotransductivity in rat calvarial bone defects", Clin Oral Implants Res, 12, pp.609~616 (2001)
  18. Bosch C, "Importance of the critical size bone defect in testing bone-regenerating materials", J Craniofac Surg, 9, pp.310~316 (1998)
  19. Donos N, "Effect of GBR in combination with deproteinized bovine bone mineral and", or enamel matrix proteins on the healing of critical-size defects, 2004, pp.15, 101~111
  20. Mah J, "The efficacy of various alloplastic bone grafts on the healing of rat calvarial defects", Eur J Orthod, 26, pp.475~482 (2004)
  21. Slotte C, "Augmentation of calvarial tissue using non-permeable silicone domes and bovine bone mineral. An experimental study in the rat", Clin Oral Implants Res, 10, pp.468~476 (1999)
  22. Carmagnola D, "Healing of human extraction sockets filled with Bio-Oss", Clin Oral Implants Res, 14, pp.137~143 (2003)
  23. Handschel J, "TCP is hardly resorbed and not osteoconductive in a non-loading calvarial model", Biomaterials, 23, pp.1689~1695 (2002)
  24. Moreira-Gonzalez A, "Evaluation of 45S5 bioactive glass combined as a bone substitute in the reconstruction of critical size calvarial defects in rabbits", J Craniofac Surg, 16, pp.63~70 (2005)
  25. Conejero JA, "Cranial defect reconstruction in an experimental model using different mixtures of bioglass and autologous bone", J Craniofac Surg, 18, pp.1290~1295 (2007)
  26. Daculsi G, "Current state of the art of biphasic calcium phosphate bioceramics", J Mater Sci Mater Med, 14, pp.195~200 (2003)
  27. Nery EB, "Tissue response to biphasic calcium phosphate ceramic with different ratio of HA", -TCP in periodontal osseous defects, 1992, pp.63, 729~723
  28. Wang C, "Proliferation and bone-related gene expression of osteoblasts grown on hydroxyapatite ceramics sintered at different temperature", Biomaterials, 25, pp.2949~2956 (2004)
  29. Barrere F, "Dalmeijer RAJ et al. Osteogenecity of octacalcium phosphate coatings applied on porous metal implants", J Biomed Mater Res A, 66, pp.779~788 (2003)
  30. Yuan H, "Bone morphogenetic protein and ceramic-induced osteogenesis", J Mater Sci Mater Med, 9, pp.717~721 (1998)
  31. Neo M, "Apatite formation of three kinds of bioactive materials at an early stage in vivo: A comparative study by transmission electron microscopy", J Biomed Mater Res, 27, pp.999~1006 (1993)
  32. Yubao L, "Formation of a bone apatite-like layer on the surface of porous hydroxyapatite ceramics", Biomaterials, 15, pp.835~841 (1994)
  33. Klinge B, "Osseous response to implanted natural bone mineral and synthetic hydroxyapatite ceramic in the repair of experimental skull bone defects", J Oral Maxillofac Surg, 50, pp.241~249 (1992)
  34. Yildirim M, "Maxillary sinus augmentation with the xenograft Bio-Oss and autogenous intraoral bone for qualitative improvement of the implant site: a histological and histomorphometric clinical study in humans", Int J Oral Maxillofac Implants, 16, pp.23~33 (2001)
  35. Sartori S, "Ten-year follow-up in a maxillary sinus augmentation using anorganic bovine bone (Bio-Oss). A case report with histomorphometric evaluation", Clin Oral Implants Res, 14, pp.369~372 (2003)

관련 논문AI추천

삼차원적으로 연결된 미세다공성 구조를 가진 이상인산칼슘 골이식재의 골치유에 관한 조직계측학적 평가류경호, 박광범, 박진우, 서조영, 이재목, 이종식, 장제희, 최석규대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제2호토끼 두개골 결손부에서 블록형과 분말형 hydroxyapatite의 골전도 효과구순자, 김창성, 손주연, 엄유정, 이용근, 임현창, 정의원, 최성호대한치주과학회 · Journal of Periodontal & Implant Science2009 · 제39권 제3호토끼 두개골에서 새로 개발된 biphasic calcium phosphate의 골형성 효과 : A pilot study김성태, 김종관, 박상현, 박준효, 엄유정, 이용호, 조규성, 최성호, 홍지연대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제2호백서 두개골 결손부에서 동결건조골과 gel/putty 형 탈회골기질의 골재생효과김득한, 방은경, 홍지연대한치주과학회 · Journal of Periodontal & Implant Science2009 · 제39권 제3호Bone regeneration capacity of two different macroporous biphasic calcium materials in rabbit calvarial defect김종관, 김창성, 박정철, 임현창, 조규성, 최성호, Jeong-Ho Yun, Joo-Yeon Sohn, Ui-Won Jung대한치주과학회 · Journal of Periodontal & Implant Science2009 · 제39권 제2호임플란트 주위 골 결손부의 이식재 크기에 따른 재생 효과 비교 연구오홍균, 임성빈, 정진형, 홍기석대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제3호

이 간행물의 다른 논문 (14건)