Bone regeneration capacity of two different macroporous biphasic calcium materials in rabbit calvarial defect
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Purpose: Synthetic bone products such as biphasic calcium phosphate (BCP) are mixtures of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). In periodontal therapies and implant treatments, BCP provides to be a good bone reconstructive material since it has a similar chemical composition to biological bone apatites. The purpose of this study was to compare bone regeneration capacity of two commercially available BCP. Methods: Calvarial defects were prepared in sixteen 9-20 months old New Zealand White male rabbits. BCP with HA and β-TCP (70:30) and BCP with Silicon-substituted hydroxyapatite (Si-HA) and β-TCP (60:40) particles were filled in each defect. Control defects were filled with only blood clots. Animals were sacrificed at 4 and 8 week postoperatively. Histomorphometric analysis was performed. Results: BCP with HAand β-TCP 8 weeks group and BCP with Si-HA and β-TCP 4 and 8 weeks groups showed statistically significant in crease (P <0.05) in augmented area than control group. Newly formed bone area after 4 and 8 weeks was similar among all the groups. Residual materials were slightly more evident in BCP with HA and β-TCP 8 weeks group. Conclusions: Based on histological results, BCP with HA and β-TCP and BCP with Si-HA and β-TCP appears to demonstrate acceptable space maintaining capacity and elicit significant new bone formation when compared to natural bone healing in 4 and 8 week periods.
Abstract
Purpose: Synthetic bone products such as biphasic calcium phosphate (BCP) are mixtures of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP). In periodontal therapies and implant treatments, BCP provides to be a good bone reconstructive material since it has a similar chemical composition to biological bone apatites. The purpose of this study was to compare bone regeneration capacity of two commercially available BCP. Methods: Calvarial defects were prepared in sixteen 9-20 months old New Zealand White male rabbits. BCP with HA and β-TCP (70:30) and BCP with Silicon-substituted hydroxyapatite (Si-HA) and β-TCP (60:40) particles were filled in each defect. Control defects were filled with only blood clots. Animals were sacrificed at 4 and 8 week postoperatively. Histomorphometric analysis was performed. Results: BCP with HAand β-TCP 8 weeks group and BCP with Si-HA and β-TCP 4 and 8 weeks groups showed statistically significant in crease (P <0.05) in augmented area than control group. Newly formed bone area after 4 and 8 weeks was similar among all the groups. Residual materials were slightly more evident in BCP with HA and β-TCP 8 weeks group. Conclusions: Based on histological results, BCP with HA and β-TCP and BCP with Si-HA and β-TCP appears to demonstrate acceptable space maintaining capacity and elicit significant new bone formation when compared to natural bone healing in 4 and 8 week periods.
참고문헌 (31)
- Barboza EP, "Clinical and histologic evaluation of the demineralized freeze-dried bone membrane used for ridge augmentation", Int J Periodontics Restorative Dent, 19, pp.601~607 (1999)
- Daculsi G, "Current state of the art of biphasic calcium phosphate bioceramics", J Mater Sci Mater Med, 14, pp.195~200 (2003)
- Daculsi G, "Macroporous calcium phosphate ceramic for long bone surgery in humans and dogs. Clinical and histological study", J Biomed Mater Res, 24, pp.379~396 (1990)
- LeGeros RZ, "Significance of the porosity and physical chemistry of calcium phosphate ceramics. Biodegradation-bioresorption", Ann N Y Acad Sci, 523, pp.268~271 (1988)
- Levin MP, "Healing of periodontal defects with ceramic implants", J Clin Periodontol, 1, pp.197~205 (1974)
- Levin MP, "Biodegradable ceramic in periodontal defects", Oral Surg Oral Med Oral Pathol, 38, pp.344~351 (1974)
- Yukna RA, "Six month evaluation of Calcitite (hydroxyapatite ceramic) in periodontal osseous defects", Int J Periodontics Restorative Dent, 6, pp.64~45 (1986)
- Froum SJ, "Human clinical and histologic responses to Durapatite implants in intraosseous lesions. Case reports", J Periodontol, 53, pp.719~725 (1982)
- Moskow BS, "Histological assessment of human periodontal defect after durapatite ceramic implant. Report of a case", J Periodontol, 54, pp.455~462 (1983)
- Ellinger RF, "Histological assessment of periodontal osseous defects following implantation of hydroxyapatite and biphasic calcium phosphate ceramics: a case report", Int J Periodontics Restorative Dent, 6, pp.22~33 (1986)
- Karabuda C, "Olgac V. Histological and clinical evaluation of 3 different grafting materials for sinus lifting procedure based on 8 cases", J Periodontol, 72, pp.1436~1442 (2001)
- Jarcho M, "Calcium phosphate ceramics as hard tissue prosthetics", Clin Orthop Relat Res, pp.259~278 (1981)
- Jarcho M, "Biomaterial aspects of calcium phosphates. Properties and applications", Dent Clin North Am, 30, pp.25~47 (1986)
- Nery EB, "Tissue response to biphasic calcium phosphate ceramic with different ratios of HA", beta TCP in periodontal osseous defects, 1992, pp.63, 729~735
- Block MS, "A comparison of particulate and solid root forms of hydroxylapatite in dog extraction sites", J Oral Maxillofac Surg, 44, pp.89~93 (1986)
- 이지현, "합성골 이식재인 Macroporous biphasic calcium phosphate를 이용한 사람의 상악동 거상술-증례 보고", The Journal of the Korean Academy of Periodontology (JPIS), 36(2), pp.567~577 (2006), 대한치주과학회
- Daculsi G, "Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization", J Biomed Mater Res, 23, pp.883~894 (1989)
- Bertoni E, "Nanocrystals of magnesium and fluoride substituted hydroxyapatite", J Inorg Biochem, 72, pp.29~35 (1998)
- Skrtic D, "Silicaand zirconia-hybridized amorphous calcium phosphate: effect on transformation to hydroxyapatite", J Biomed Mater Res, 59, pp.597~604 (2002)
- Hollinger JO, "The critical size defect as an experimental model to test bone repair materials", J Craniofac Surg, 1, pp.60~68 (1990)
- Marx RE, "Platelet-rich plasma: Growth factor enhancement for bone grafts", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 85, pp.638~646 (1998)
- Sandy J, "Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells", Bone, 23, pp.17~26 (1998)
- Horner A, "Compston JE. Distribution of platelet-derived growth factor (PDGF) A chain mRNA, protein, and PDGF-alpha receptor in rapidly forming human bone", Bone, 19, pp.353~362 (1996)
- 이용준, "백서 두개골 결손부에서 bone morphogenetic protein-2의 전달체로서 macroporous biphasic calcium phosphate-block의 골재생효과", The Journal of the Korean Academy of Periodontology (JPIS), 37(5), pp.397~407 (2007), 대한치주과학회
- Wikesjo UM, "Bone morphogenetic proteins: a realistic alternative to bone grafting for alveolar reconstruction", Oral Maxillofac Surg Clin North Am, 19, pp.535~551 (2007)
- Klein CP, "Biodegradation behavior of various calcium phosphate materials in bone tissue", J Biomed Mater Res, 17, pp.769~784 (1983)
- Kwon S, "Synthesis and dissolution behavior of β-TCP and HA", β-TCP composite powders, 2003, pp.23, 1039~1045
- Gauthier O, "Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth", Biomaterials, 19, pp.133~139 (1998)
- LeGeros RZ, "Calcium phosphate materials in restorative dentistry: a review", Adv Dent Res, 2, pp.164~180 (1988)
- Metsger DS, "Tricalcium phosphate ceramic--a resorbable bone implant: review and current status", J Am Dent Assoc, 105, pp.1035~1038 (1982)
- 엄유정, "토끼 두개골에서 새로 개발된 biphasic calcium phosphate의 골형성 효과 : A pilot study", The Journal of the Korean Academy of Periodontology (JPIS), 38(2), pp.163~170 (2008), 대한치주과학회