본문 바로가기
KERD
논문KCI 등재

백서 두개골 결손부에서 동결건조골과 gel/putty 형 탈회골기질의 골재생효과

The effect of the freeze dried bone allograft and gel/putty type demineralized bone matrix on osseous regeneration in the rat calvarial defects

홍지연|방은경|김득한
대한치주과학회 (The Korean Academy Of Periodontology)|2009.09|Journal of Periodontal & Implant Science|제39권 제3호|pp. 349-358

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

homologous
주제분류치의학

초록

Purpose: This study was aimed to evaluate the effect of the Freeze Dried Bone Allograft and Demineralized Bone Matrix on osseous regeneration in the rat calvarial defects. Methods: Eight mm critical-sized calvarial defects were created in the 80 male Sprague-Dawley rats. The animals were divided into 4 groups of 20 animals each. The defects were treated with Freeze Dried Bone Allograft(SureOss ™ ), Demineralized Bone Matrix(ExFuse ™ Gel, ExFuse ™ Putty), or were left untreated for sham-surgery control and were evaluated by histologic and histomorphometric parameters following a 2 and 8 week healing intervals. Statistical analysis was done between each groups and time intervals with ANOVA and paired t-test. Results: Defect closure, New bone area, Augmented area in the SureOss ™ , ExFuse ™ Gel, ExFuse ™ Putty groups were significantly greater than in the sham-surgery control group at each healing interval(P < 0.05). In the New bone area and Defect closure, there were no significant difference between experimental groups. Augmented area in the ExFuse ™ Gel, ExFuse ™ Putty groups were significantly greater than SureOss ™ group at 2weeks(P < 0.05), however there was no significant difference at 8 weeks. Conclusions: All of SureOss ™ , ExFuse ™ Gel, ExFuse ™ Putty groups showed significant new bone formation and augmentation in the calvarial defect model. (J Korean Acad Periodontol 2009;39:349-358)

Abstract

Purpose: This study was aimed to evaluate the effect of the Freeze Dried Bone Allograft and Demineralized Bone Matrix on osseous regeneration in the rat calvarial defects. Methods: Eight mm critical-sized calvarial defects were created in the 80 male Sprague-Dawley rats. The animals were divided into 4 groups of 20 animals each. The defects were treated with Freeze Dried Bone Allograft(SureOss ™ ), Demineralized Bone Matrix(ExFuse ™ Gel, ExFuse ™ Putty), or were left untreated for sham-surgery control and were evaluated by histologic and histomorphometric parameters following a 2 and 8 week healing intervals. Statistical analysis was done between each groups and time intervals with ANOVA and paired t-test. Results: Defect closure, New bone area, Augmented area in the SureOss ™ , ExFuse ™ Gel, ExFuse ™ Putty groups were significantly greater than in the sham-surgery control group at each healing interval(P < 0.05). In the New bone area and Defect closure, there were no significant difference between experimental groups. Augmented area in the ExFuse ™ Gel, ExFuse ™ Putty groups were significantly greater than SureOss ™ group at 2weeks(P < 0.05), however there was no significant difference at 8 weeks. Conclusions: All of SureOss ™ , ExFuse ™ Gel, ExFuse ™ Putty groups showed significant new bone formation and augmentation in the calvarial defect model. (J Korean Acad Periodontol 2009;39:349-358)

참고문헌 (36)

  1. Misch CE, "Bone-grafting materials in implant dentistry", Implant Dent, 2, pp.158~167 (1993)
  2. Lane JM, "Bone graft substitutes", West J Med, 163, pp.565~566 (1995)
  3. Hislop WS, "A preliminary study into the uses of anorganic bone in oral and maxillofacial surgery", Br J Oral Maxillofac Surg, 31, pp.149~153 (1993)
  4. Rummelhart JM, "A comparison of freeze-dried bone allograft and demineralized freeze-dried bone allograft in human periodontal osseous defects", J Periodontol, 60, pp.655~663 (1989)
  5. Sung-Hee Kim, "Clinical study on therapeutic effects of decalcified freeze dried bone allograft in intrabony defects", J Korean Acad Periodontol, 24, pp.618~632 (1994)
  6. Eun Ju Lee, "Histologic Study on Healing after Implantation of several Bone Substitutes in Rat Calvarial Defects", J Korean Acad Periodontol, 28, pp.87~102 (1998)
  7. Schepers EJ, "Bioactive glass particles of narrow size range: a new material for the repair of bone defects", Implant Dent, 2, pp.151~156 (1993)
  8. Urist MR, "Bone formation by augmentation", Science, 150, pp.892~ (1965)
  9. Libin BM, "Decalcified, lyophilized bone allografts for use in human periodontal defects", J Periodontol, 46, pp.51~56 (1975)
  10. Acil Y, "Effects of bone morphogenetic protein-7 stimulation on osteoblasts cultured on different biomaterials", J Cell Biochem, 86, pp.90~98 (2002)
  11. Wikesjo UM, "RhBMP-2", alphaBSM induces significant vertical alveolar ridge augmentation and dental implant osseointegration, 2002, pp.4, 174~182
  12. Piattelli A, "Comparison of bone regeneration with the use of mineralized and demineralized freeze-dried bone allografts: a histological and histochemical study in man", Biomaterials, 17, pp.1127~1131 (1996)
  13. Bowers GM, "Chadroff B, Carnevale R et al. Histologic evaluation of new attachment apparatus formation in humans. Part I", J Periodontol, 60, pp.664~674 (1989)
  14. Bowers GM, "Histologic valuation of new attachment apparatus formation in humans. Part II", J Periodontol, 60, pp.675~682 (1989)
  15. Strates BS, "Contribution of osteoinductive and osteoconductive properties of demineralized bone matrix to skeletal repair", Eur J Exp Musculoskel Res, 2, pp.61~ (1993)
  16. Kathleen D, Chesmel, "Healing response to various forms of humans demineralized bone matrix in athymic rat cranial defects", J Oral Maxillofac Surg, 56, pp.857~863 (1998)
  17. Bowers GM, "Carnevale R et al. Histologic evaluation of new attachment apparatus formation in humans. Part III", J Periodontol, 60, pp.683~693 (1989)
  18. 홍소미, "동결건조골이 재생공간 유지 및 골재생에 미치는 영향", The Journal of the Korean Academy of Periodontology (JPIS), 34(1), pp.149~162 (2004), 대한치주과학회
  19. Garg, Arun K, "Bone biology, harvesting, and grafting for dental implants : rationale and clinical applications", pp.21~57 (2004), Quintessence
  20. Mellonig JT, "Comparison of bone graft materials. Part II. New bone formation with autografts and allografts: a histological evaluation", J Periodontol, 52, pp.297~302 (1981)
  21. Mellonig JT, "Clinical evaluation of freeze-dried bone allografts in periodontal osseous defects", J Periodontol, 47, pp.125~131 (1976)
  22. Sepe WW, "Clinical evaluation of freeze-dried bone allografts in periodontal osseous defects-part II", J Periodontol, 49, pp.9~14 (1978)
  23. Frame JW, "Hydroxyapatite as a biomaterial for alveolar ridge augmentation", Int J Oral Maxillofac Surg, 16, pp.642~655 (1987)
  24. Pinholt EM, "Alveolar ridge augmentation in rats by combined hydroxylapatite and osteoinductive material", Scand J Dent Res, 99, pp.64~74 (1991)
  25. Babbush CA, "Histologic evaluation of human biopsies after dental augmentation with a demineralized bone matrix putty", Implant Dent, 12, pp.325~332 (2003)
  26. Matzenbacher SA, "In vivo effectiveness of a glycerol-compounded demineralized freeze-dried bone xenograft in the rat calvarium", J Periodontol, 74, pp.1641~1646 (2003)
  27. N. Senn, "On the Healing of Aseptic Bone Cavities by Implantation of Antiseptic Decalcified Bone", Am J Med Sci, 10, pp.352~368 (1889)
  28. Mellonig JT, "Clinical evaluation of freeze-dried bone allografts in periodontal osseous defects", J Periodontol, 47, pp.125~131 (1976)
  29. Meffert RM, "Current usage of bone fill as an adjunct in implant dentistry", Dent Implantol Update, 9, pp.9~12 (1998)
  30. Herold RW, "The effects of varying degrees of allograft decalcification on cultured porcine osteoclast cells", J Periodontol, 73, pp.213~219 (2002)
  31. Yukna RA, "Comparative evaluation of decalcified and non- decalcified freeze-dried bone allografts in rhesus monkeys. I. Histologic findings", J Periodontol, 76, pp.57~65 (2005)
  32. Rosen PS, "A retrospective case series comparing the use of demineralized freeze-dried bone allograft and freeze-dried bone allograft combined with enamel matrix derivative for the treatment of advanced osseous lesions", J Periodontol, 73, pp.942~949 (2002)
  33. Rummelhart JM, "A comparison of freeze-dried bone allograft and demineralized freeze-dried bone allograft in human periodontal osseous defects", J Periodontol, 60, pp.655~663 (1989)
  34. Cammack GV 2nd, "Histologic evaluation of mineralized and demineralized freeze-dried bone allograft for ridge and sinus augmentations", Int J Periodontics Restorative Dent, 25, pp.231~237 (2005)
  35. Kalish BP, "Influence of matrix-suspended demineralized bone on osseous repair using a critical-sized defect in the rat (Rattus norvegicus) calvarium", Oral Implantol, 34, pp.83~89 (2008)
  36. Bender SA, "Evaluation of demineralized bone matrix paste and putty in periodontal intraosseous defects", J Periodontol, 76, pp.768~777 (2005)

관련 논문AI추천

토끼 두개골 결손부에서 블록형과 분말형 hydroxyapatite의 골전도 효과구순자, 김창성, 손주연, 엄유정, 이용근, 임현창, 정의원, 최성호대한치주과학회 · Journal of Periodontal & Implant Science2009 · 제39권 제3호A study of bone regeneration effect according to the two different graft bone materials in the cranial defects of rabbits김병옥, 민귀현, 유상준, 이원표, Hyun-Jong Song, Hyun-Woo Kim치의학연구원 · Oral Biology Research2018 · 제42권 제4호탈회동결건조골이 수직골 형성에 미치는 영향허익, 권영혁, 박주희, 박준봉, 신승일, 정종혁대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제1호백서 두개골 결손에서 rhBMP-2와 다양한 carrier의 골재생 유도효과강은정, 김종관, 김지선, 김창성, 엄태관, 이서경, 조규성, 채중규, 최성호대한치주과학회 · Journal of Periodontal & Implant Science2008 · 제38권 제2호백서에서 흡수성막과 탈회동결건조골을 이용한 두개골결손부의 골재생김미숙, 김수관, 여환호, 임성철대한구강악안면외과학회 · 대한구강악안면외과학회지2002 · 제28권 제4호Bone regeneration effects of human allogenous bone substitutes: a preliminary study구영, 구기태, 김태일, 류인철, 설양조, 이덕원, 이용무, 정종평대한치주과학회 · Journal of Periodontal & Implant Science2010 · 제40권 제3호

이 간행물의 다른 논문 (9건)

상악동 거상술을 동반한 임플란트 식립 후 생존율에 대한 후향적 연구조규성, 유정아, 최성호, 김창성, 이상민, 박필규, 정의원, 유미경pp. 293-301클로르헥시딘이 초음파 치석제거기에 의해 발생된 에어로졸 내 세균 수에 미치는 영향신승윤, 계승범, 양승민, 손우경pp. 303-310조절되는 당뇨환자에게 식립된 치과 임플란트의 생존율에 대한 후향적 연구최성호, 김영희, 조규성, 정의원, 김창성, 엄유정pp. 311-320토끼 두개골 결손부에서 블록형과 분말형 hydroxyapatite의 골전도 효과구순자, 이용근, 엄유정, 임현창, 김창성, 손주연, 정의원, 최성호pp. 321-329치주인대세포에서 Aggregatibacter actinomycetemcomitans의 IL-8 및 활성산소종 유도능차정헌, 유윤정, 박홍규, 김성환, 이양신pp. 331-337
원문 보기