삼차원적으로 연결된 미세다공성 구조를 가진 이상인산칼슘 골이식재의 골치유에 관한 조직계측학적 평가
Histomorphometric evaluation of bone healing with fully interconnected microporous biphasic calcium phosphate ceramics in rabbit calvarial defects
2
조회
0
다운로드
3
인용
0
참고문헌
초록
Purpose: The purpose of this study was to histomorphometrically evaluate the osteoconductivity of a new biphasic calcium phosphate ceramics with fully interconnected microporous structure.Material and Methods: Osseous defects created in the rabbit calvaria were filled with four different bone graft substitutes. Experimental sites were filled with a new fully interconnected microporous biphasic calcium phosphate with(BCP-2) or without(BCP-1) internal macropore of 400㎛ in diameter. MBCP(Biomatlante, France) and Bio-Oss(Geistlich Pharma, Switzerland) were used as controls in this study. Histomorphometric evaluation was performed at 4 and 8 weeks after surgery.Result: In histologic evaluation, new bone formation and direct bony contact with the graft particles were observed in all four groups. At 4 weeks, BCP-1(15.5%) and BCP-2(15.5%) groups showed greater amount of newly formed mineralized bone area(NB%) compared to BO(11.4%) and MBCP(10.3%) groups. The amounts of NB% at 8 weeks were greater than those of 4 weeks in all four groups, but there was no statistically significant differences in NB% between the groups. Conclusion: These results indicate that new bone substitutes, BCP with interconnected microporous structure and with or without internal macroporous structures, have the osteoconductivity comparable to those of commercially available bone substitutes, MBCP and Bio-Oss. (J Korean Acad Periodontol 2008;38:117-124)
Abstract
Purpose: The purpose of this study was to histomorphometrically evaluate the osteoconductivity of a new biphasic calcium phosphate ceramics with fully interconnected microporous structure.Material and Methods: Osseous defects created in the rabbit calvaria were filled with four different bone graft substitutes. Experimental sites were filled with a new fully interconnected microporous biphasic calcium phosphate with(BCP-2) or without(BCP-1) internal macropore of 400㎛ in diameter. MBCP(Biomatlante, France) and Bio-Oss(Geistlich Pharma, Switzerland) were used as controls in this study. Histomorphometric evaluation was performed at 4 and 8 weeks after surgery.Result: In histologic evaluation, new bone formation and direct bony contact with the graft particles were observed in all four groups. At 4 weeks, BCP-1(15.5%) and BCP-2(15.5%) groups showed greater amount of newly formed mineralized bone area(NB%) compared to BO(11.4%) and MBCP(10.3%) groups. The amounts of NB% at 8 weeks were greater than those of 4 weeks in all four groups, but there was no statistically significant differences in NB% between the groups. Conclusion: These results indicate that new bone substitutes, BCP with interconnected microporous structure and with or without internal macroporous structures, have the osteoconductivity comparable to those of commercially available bone substitutes, MBCP and Bio-Oss. (J Korean Acad Periodontol 2008;38:117-124)
참고문헌 (40)
- Hiatt WH, "Intraoral transplants of cancellous bone and marrow in periodontal lesions", J Periodontol, 44, pp.194~208 (1973)
- Schallhorn RG, "Present status of osseous grafting procedures", J Periodontol, 48, pp.570~576 (1977)
- Ellegaard B, "New attachment after treatment of intrabony defects in monkeys", J Periodontol, 45, pp.368~377 (1974)
- Quattlebaum JB, "Antigenicity of freeze-dried cortical bone allograft in human periodontal osseous defects", J Periodontol, 59, pp.394~397 (1988)
- Schwartz Z, "Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation", J Periodontol, 67, pp.918~926 (1996)
- Schwartz Z, "Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation is dependent on donor age but not gender", J Periodontol, 69, pp.470~478 (1998)
- Sogal A, "Risk assessment of bovine spongiform encephalopathy transmission through bone graft material derived from bovine bone used for dental applications", J Periodontol, 70, pp.1053~1063 (1999)
- Han T, "Calcium phosphate ceramics in dentistry: a review of the literature", J West Soc Periodontol Periodontal Abstr, 32, pp.88~108 (1984)
- Froum SJ, "Human clinical and histologic responses to Durapatite implants in intraosseous lesions. Case reports", J Periodontol, 53, pp.719~725 (1982)
- Moskow BS, "Histological assessment of human periodontal defect after durapatite ceramic implant. Report of a case", J Periodontol, 54, pp.455~462 (1983)
- Levin MP, "Healing of periodontal defects with ceramic implants", J Clin Periodontol, 1, pp.197~205 (1974)
- Yukna RA, "Evaluation of durapatite ceramic as an alloplastic implant in periodontal osseous defects. II. Twelve month reentry results", J Periodontol, 56, pp.540~547 (1985)
- Ellinger RF, "Histological assessment of periodontal osseous defects following implantation of hydroxyapatite and biphasic calcium phosphate ceramics: a case report", Int J Periodontics Restorative Dent, 6, pp.22~33 (1986)
- Jarcho M, "Calcium phosphate ceramics as hard tissue prosthetics", Clin Orthop Relat Res, 157, pp.259~278 (1981)
- Buser D, "Evaluation of filling materials in membrane- protected bone defects. A comparative histomorphometric study in the mandible of miniature pigs", Clin Oral Implants Res, 9, pp.137~150 (1998)
- Nery EB, "Tissue response to biphasic calcium phosphate ceramic with different ratios of HA", beta TCP in periodontal osseous defects, 1992, pp.63, 729~735
- LeGeros RZ, "Biphasic calcium phosphate bioceramics: preparation, properties and applications", J Mater Sci Mater Med, 14, pp.201~209 (2003)
- Schwartz C, "Biphasic synthetic bone substitute use in orthopaedic and trauma surgery: clinical, radiological and histological results", J Mater Sci Mater Med, 10, pp.821~825 (1999)
- Daculsi G, "Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization", J Biomed Mater Res, 23, pp.883~894 (1989)
- Daculsi G, "Crystal dissolution of biological and ceramic apatites", Calcif Tissue Int, 45, pp.95~103 (1989)
- Daculsi G, "Formation of carbonate-apatite crystals after implantation of calcium phosphate ceramics", Calcif Tissue Int, 46, pp.20~27 (1990)
- Gauthier O, "Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth", Biomaterials, 19, pp.133~139 (1998)
- Berube P, "The effect of sputtered calcium phosphate coatings of different crystallinity on osteoblast differentiation", J Periodontol, 76, pp.1697~1709 (2005)
- Rohanizadeh R, "Apatite precipitation after incubation of biphasic calcium-phosphate ceramic in various solutions: influence of seed species and proteins", J Biomed Mater Res, 42, pp.530~539 (1998)
- Eggli PS, "Porous hydroxyapatite and tricalcium phosphate cylinders with two different pore size ranges implanted in the cancellous bone of rabbits. A comparative histomorphometric and histologic study of bony ingrowth and implant substitution", Clin Orthop Relat Res, 232, pp.127~138 (1988)
- Lu JX, "Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo", J Mater Sci Mater Med, 10, pp.111~120 (1999)
- Flautre B, "Porous HA ceramic for bone replacement: role of the pores and interconnections - experimental study in the rabbit", J Mater Sci Mater Med, 12, pp.679~682 (2001)
- Chang BS, "Osteoconduction at porous hydroxyapatite with various pore configurations", Biomaterials, 21, pp.1291~1298 (2000)
- 박광범, "미세다공성 Biphasic calcium phosphate ceramics의 골이식 대체재로서의 기본특성에 대한 비교연구", Journal of Periodontal & Implant Science, 36(4), pp.797~808 (2006), 대한치주과학회
- Frame JW, "A convenient animal model for testing bone substitute materials", J Oral Surg, 38, pp.176~180 (1980)
- Sirola K, "Regeneration of defects in the calvaria. An experimental study", Ann Med Exp Biol Fenn, 38, pp.1~87 (1960)
- Schmitz JP, "The critical size defect as an experimental model for craniomandibulofacial nonunions", Clin Orthop Relat Res, 205, pp.299~308 (1986)
- Lundgren D, "Guided bone regeneration of cranial defects, using biodegradable barriers: an experimental pilot study in the rabbit", J Craniomaxillofac Surg, 20, pp.257~260 (1992)
- Kramer IR, "A histological and radiological comparison of the healing of defects of the rabbit calvarium with and without implanted heterogeneous anorganic bone", Arch Oral Biol, 13, pp.1095~1106 (1968)
- Le Guehennec L, "Small-animal models for testing macroporous ceramic bone substitutes", J Biomed Mater Res B Appl Biomater, 72, pp.69~78 (2005)
- Lecomte A, "Biphasic calcium phosphate: A comparative study of interconnected porosity in two ceramics", J Mater Sci Mater Med, 84, pp.1~6 (2008)
- Karageorgiou V, "Porosity of 3D biomaterial scaffolds and osteogenesis", Biomaterials, 26, pp.5474~5491 (2005)
- Klinge B, "Osseous response to implanted natural bone mineral and synthetic hydroxyapatite ceramic in the repair of experimental skull bone defects", J Oral Maxillofacial Surg, 50, pp.241~249 (1992)
- Sartori S, "Ten-year follow-up in a maxillary sinus augmentation using anorganic bovine bone (Bio-Oss). A case report with histomorphometric evaluation", Clin Oral Implants Res, 14, pp.369~372 (2003)
- Lee YM, "Bone reaction to bovine hydroxyapatite for maxillary sinus floor augmentation: histologic results in humans", Int J Periodontics Restorative Dent, 26, pp.471~481 (2006)
