한국인 하악전돌증환자의 유전적 영향과 유전율에 대한 분석
Genetic influence and heritability in mandibular prognathism of Korean families
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Introduction: This study examined the genetic influence of mandibular prognathism epidemiologically in Korean families. Materials and Methods: Over a 5-year period from 2005 to 2009, a questionnaire with a pedigree chart was given to 100 (male 51, female 49)probands with skeletal Class III mandibular prognathism, who had undergone orthognathic surgery in Samsung Medical Center. Results: The average age of the probands was 22.1. The average SNA, SNB and ANB angles of the probands were 81.2, 84.1and -2.9, respectively. A total of 2729 (male 1,354, female 1,375) family members were examined, and the affected ratio of the families was 3.5% with no significant difference between genders. 45% of families had at least one member with a Class III malocclusion other than the proband. The affected ratio of the first-degree relatives (10.9%) was significantly higher than those of the second-degree (3.3%) and third-degree (1.9%) relatives. The affected ratio of the total relatives from the male probands (4.2%) was significantly higher than that of the female probands (2.8%). Heritability (h2, Falconer’method)was estimated to be 29.8% (0.298±0.059) in first-degree relatives. Conclusion: These results showed the significant influence of mandibular prognathism with relatively low heritability in first-degree relatives in Korean families of probands, who had undergone orthognathic surgery to correct a skeletal Class III malocclusion
Abstract
Introduction: This study examined the genetic influence of mandibular prognathism epidemiologically in Korean families. Materials and Methods: Over a 5-year period from 2005 to 2009, a questionnaire with a pedigree chart was given to 100 (male 51, female 49)probands with skeletal Class III mandibular prognathism, who had undergone orthognathic surgery in Samsung Medical Center. Results: The average age of the probands was 22.1. The average SNA, SNB and ANB angles of the probands were 81.2, 84.1and -2.9, respectively. A total of 2729 (male 1,354, female 1,375) family members were examined, and the affected ratio of the families was 3.5% with no significant difference between genders. 45% of families had at least one member with a Class III malocclusion other than the proband. The affected ratio of the first-degree relatives (10.9%) was significantly higher than those of the second-degree (3.3%) and third-degree (1.9%) relatives. The affected ratio of the total relatives from the male probands (4.2%) was significantly higher than that of the female probands (2.8%). Heritability (h2, Falconer’method)was estimated to be 29.8% (0.298±0.059) in first-degree relatives. Conclusion: These results showed the significant influence of mandibular prognathism with relatively low heritability in first-degree relatives in Korean families of probands, who had undergone orthognathic surgery to correct a skeletal Class III malocclusion
참고문헌 (25)
- Nakasima A, "Genetic and environmental factors in the development of so-called pseudo- and true mesiocclusions", Am J Orthod Dentofacial Orthop, 90, pp.106~116 (1986)
- Litton SF, "A genetic study of Class 3 malocclusion", Am J Orthod, 58, pp.565~577 (1970)
- Newman GV, "Prevalence of malocclusion in children six to fourteen years of age and treatment in preventable cases", J Am Dent Assoc, 52, pp.566~575 (1956)
- Emrich RE, "Prevalence of Class 1, Class 2, and Class 3 malocclusions (Angle) in an urban population. An epidemiological study", J Dent Res, 44, pp.947~953 (1965)
- Proffit WR, "Prevalence of malocclusion and orthodontic treatment need in the United States: estimates from the NHANES III survey", Int J Adult Orthodon Orthognath Surg, 13, pp.97~106 (1998)
- Garner LD, "Malocclusion in black Americans and Nyeri Kenyans. An epidemiologic study", Angle Orthod, 55, pp.139~146 (1985)
- Ishii H, "Treatment effect of combined maxillary protraction and chincap appliance in severe skeletal Class III cases", Am J Orthod Dentofacial Orthop, 92, pp.304~312 (1987)
- Kang HK, "A study on the prevalence of malocclusion of Yonsei university students in 1991", Korean J Orthod, 22, pp.691~701 (1992)
- Yoo YK, "A study on the prevalence of malocclusion in 2,378 Yonsei university students", Korean J Orthod, 2, pp.35~40 (1971)
- Pascoe JJ, "Mandibular prognathism: its etiology and a classification", J Oral Surg Anesth Hosp Dent Serv, 18, pp.21~24 (1960)
- Gold JK, "A new approach to the treatment of mandibular prognathism", Am J Orthod, 35, pp.893~912 (1949)
- Watanabe M, "Mandibular prognathism in Japanese families ascertained through orthognathically treated patients", Am J Orthod Dentofacial Orthop, 128, pp.466~470 (2005)
- Wolff G, "On the genetics of mandibular prognathism: analysis of large European noble families", J Med Genet, 30, pp.112~116 (1993)
- El-Gheriani AA, "Segregation analysis of mandibular prognathism in Libya", J Dent Res, 82, pp.523~527 (2003)
- Cruz RM, "Major gene and multifactorial inheritance of mandibular prognathism", Am J Med Genet A, 146, pp.71~77 (2008)
- Falconer DS, "Introduction to quantitative genetics. 4th ed" (1996), Longman
- Falconer DS, "The inheritance of liability to certain diseases, estimated from the incidence among relatives", Ann Hum Genet, 29, pp.51~76 (1965)
- 이창환, "골격성 하악전돌증 환자의 유전적 경향에 대한 분석", 대한구강악안면외과학회지, 32(6), pp.506~513 (2006), 대한구강악안면외과학회
- Jacobson A, "Mandibular prognathism", Am J Orthod, 66, pp.140~171 (1974)
- Thompson EM, "Another family with the ‘Habsburg jaw’", J Med Genet, 25, pp.838~842 (1988)
- Oh J, "A genome segment on mouse chromosome 12 determines maxillary growth", J Dent Res, 86, pp.1203~1206 (2007)
- Dohmoto A, "Quantitative trait loci on chromosomes 10 and 11 influencing mandible size of SMXA RI mouse strains", J Dent Res, 81, pp.501~504 (2002)
- Yamaguchi T, "Genomewide linkage analysis of mandibular prognathism in Korean and Japanese patients", J Dent Res, 84, pp.255~259 (2005)
- Frazier-Bowers S, "Evidence of linkage in a Hispanic cohort with a Class III dentofacial phenotype", J Dent Res, 88, pp.56~60 (2009)
- Bui C, "Phenotypic characterization of Class III patients", Angle Orthod, 76, pp.564~569 (2006)