Influence of heritability on craniofacial soft tissue characteristics of monozygotic twins, dizygotic twins, and their siblings using Falconer’s method and principal components analysis
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objective: The purpose of this study was to investigate the influence of heritability on the craniofacial soft tissue cephalometric characteristics of monozygotic (MZ) twins, dizygotic (DZ) twins, and their siblings (SIB). Methods: The samples comprised Korean adult twins and their siblings (mean age, 39.8 years; MZ group, n = 36 pairs; DZ group, n = 13 pairs of the same gender; and SIB group, n = 26 pairs of the same gender). Thirty cephalometric variables were measured to characterize facial profile, facial height, soft-tissue thickness, and projection of nose and lip. Falconer’s method was used to calculate heritability (low heritability, h2 < 0.2; high heritability, h2 > 0.9). After principal components analysis (PCA) was performed to extract the models, we calculated the intraclass correlation coefficient (ICC) value and heritability of each component. Results: The MZ group exhibited higher ICC values for all cephalometric variables than DZ and SIB groups. Among cephalometric variables, the highest h2 (MZ-DZ) and h2 (MZ-SIB) values were observed for the nasolabial angle (NLA, 1.544 and 2.036), chin angle (1.342 and 1.112), soft tissue chin thickness (2.872 and 1.226), and upper lip thickness ratio (1.592 and 1.026). PCA derived eight components with 84.5% of a cumulative explanation. The components that exhibited higher values of h2 (MZ-DZ) and h2 (MZ-SIB) were PCA2, which includes facial convexity, NLA, and nose projection (1.026 and 0.972), and PCA7, which includes chin angle and soft tissue chin thickness (2.107 and 1.169). Conclusions: The nose and soft tissue chin were more influenced by genetic factors than other soft tissues.
Abstract
Objective: The purpose of this study was to investigate the influence of heritability on the craniofacial soft tissue cephalometric characteristics of monozygotic (MZ) twins, dizygotic (DZ) twins, and their siblings (SIB). Methods: The samples comprised Korean adult twins and their siblings (mean age, 39.8 years; MZ group, n = 36 pairs; DZ group, n = 13 pairs of the same gender; and SIB group, n = 26 pairs of the same gender). Thirty cephalometric variables were measured to characterize facial profile, facial height, soft-tissue thickness, and projection of nose and lip. Falconer’s method was used to calculate heritability (low heritability, h2 < 0.2; high heritability, h2 > 0.9). After principal components analysis (PCA) was performed to extract the models, we calculated the intraclass correlation coefficient (ICC) value and heritability of each component. Results: The MZ group exhibited higher ICC values for all cephalometric variables than DZ and SIB groups. Among cephalometric variables, the highest h2 (MZ-DZ) and h2 (MZ-SIB) values were observed for the nasolabial angle (NLA, 1.544 and 2.036), chin angle (1.342 and 1.112), soft tissue chin thickness (2.872 and 1.226), and upper lip thickness ratio (1.592 and 1.026). PCA derived eight components with 84.5% of a cumulative explanation. The components that exhibited higher values of h2 (MZ-DZ) and h2 (MZ-SIB) were PCA2, which includes facial convexity, NLA, and nose projection (1.026 and 0.972), and PCA7, which includes chin angle and soft tissue chin thickness (2.107 and 1.169). Conclusions: The nose and soft tissue chin were more influenced by genetic factors than other soft tissues.
참고문헌 (28)
- Hunter WS, "A study of the inheritance of craniofacial characteristics as seen in lateral cephalograms of 72 like-sexed twins", Rep Congr Eur Orthod Soc, 41, pp.59~70 (1965)
- Nakata N, "The use of genetic data in the prediction of craniofacial dimensions", Am J Orthod, 63, pp.471~480 (1973)
- Nakasima A, "Hereditary factors in the craniofacial morphology of Angle's Class II and Class III malocclusions", Am J Orthod, 82, pp.150~156 (1982)
- Manfredi C, "Heritability of 39 orthodontic cephalometric parameters on MZ, DZ twins and MN-paired singletons", Am J Orthod Dentofacial Orthop, 111, pp.44~51 (1997)
- Savoye I, "A genetic study of anteroposterior and vertical facial proportions using model-fitting", Angle Orthod, 68, pp.467~470 (1998)
- Carels C, "A quantitative genetic study of cephalometric variables in twins", Clin Orthod Res, 4, pp.130~140 (2001)
- Johannsdottir B, "Heritability of craniofacial characteristics between parents and offspring estimated from lateral cephalograms", Am J Orthod Dentofacial Orthop, 127, pp.200~207 (2005)
- Amini F, "Heritability of dental and skeletal cephalometric variables in monozygous and dizygous Iranian twins", Orthod Waves, 68, pp.72~79 (2009)
- Ackerman JL, "Soft tissue limitations in orthodontics : treatment planning guidelines", Angle Orthod, 67, pp.327~336 (1997)
- Terajima M, "A 3-dimensional method for analyzing facial soft-tissue morphology of patients with jaw deformities", Am J Orthod Dentofacial Orthop, 135, pp.715~722 (2009)
- Vanco C, "Genetic and environmental influences on facial profile", Aust Dent J, 40, pp.104~109 (1995)
- Naini FB, "Three-dimensional assessment of the relative contribution of genetics and environment to various facial parameters with the twin method", Am J Orthod Dentofacial Orthop, 126, pp.655~665 (2004)
- Baydaş B, "Heritability of facial proportions and soft-tissue profile characteristics in Turkish Anatolian siblings", Am J Orthod Dentofacial Orthop, 131, pp.504~509 (2007)
- Sipahioğlu S, "Midline facial soft tissue thickness database of Turkish population : MRI study", Forensic Sci Int, 219, pp.282.e1~282.e8 (2012)
- 김현진, "Heritabilities of Facial Measurements and Their Latent Factors in Korean Families", Genomics & Informatics, 11(2), pp.83~92 (2013), 한국유전체학회[DOI]
- Weinberg SM, "Heritability of face shape in twins : a preliminary study using 3D stereophotogrammetry and geometric morphometrics", Dent 3000, 1, pp.14~ (2013)
- Baillie LJ, "Ancestry and BMI influences on facial soft tissue depths for a cohort of Chinese and caucasoid women in Dunedin, New Zealand", J Forensic Sci, 60, pp.1146~1154 (2015)
- Thiemann N, "In vivo facial soft tissue depths of a modern adult population from Germany", Int J Legal Med, 131, pp.1455~1488 (2017)
- Kim E, "Heritability of facial skeletal and dental characteristics of monozygotic and dizygotic twins using cephalometric analysis and Falconer's method", J Craniofac Surg, 29, pp.e274~e279 (2018)
- Shrout PE, "Intraclass correlations : uses in assessing rater reliability", Psychol Bull, 86, pp.420~428 (1979)
- Falconer DS, "Introduction to quantitative genetics" (1975), Prentice Hall Press
- Šidlauskas M, "Heritability of mandibular cephalometric variables in twins with completed craniofacial growth", Eur J Orthod, 38, pp.493~502 (2016)
- Mayer C, "BMI and WHR are reflected in female facial shape and texture : a geometric morphometric image analysis", PLoS One, 12, pp.e0169336~ (2017)
- Tsagkrasoulis D, "Heritability maps of human face morphology through large-scale automated three-dimensional phenotyping", Sci Rep, 7, pp.45885~ (2017)
- Djordjevic J, "Genetic and environmental contributions to facial morphological variation : A 3D populationbased twin study", PLoS One, 11, pp.e0162250~ (2016)
- Macari AT, "Comparisons of soft tissue chin thickness in adult patients with various mandibular divergence patterns", Angle Orthod, 84, pp.708~714 (2014)
- Somaiah S, "Comparison of soft tissue chin thickness in adult patients with various mandibular divergence patterns in Kodava population", Int J Orthod Rehabil, 8, pp.51~56 (2017)
- Kurkcuoglu A, "Facial soft tissue thickness in individuals with different occlusion patterns in adult Turkish subjects", Homo, 62, pp.288~297 (2011)