혈청 감마지티(gamma-glutamyltransferase)와 당뇨병 유병률과의 상관관계
Relations between serum gamma-lutamyltransferase and prevalence of diabetes mellitus
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연구배경 : GGT는 세포내 glutathione 농도를 유지함으로써 세포내 산화 방지제 역할을 하는 것으로 oxidative stress에 대한 지표가 될 수 있다. 최근 oxidative stress와 당뇨병과의 연관이 있는 것으로 알려져 GGT와 당뇨병 유병율과의 관계를 연구하였다. 방법 : 2002년 1월 1일부터 2002년 12월 31일까지 1년간 연세대학교 원주의대 부속 원주기독병원에서 건강검진을 받은 남자를 대상으로 cross sectional study를 시행하여 GGT와 당뇨병 유병율의 상관관계를 알아 보았다. 결과 : GGT와 나이, 체질량지수, 총 콜레스테롤, 수축기 혈압, 이완기 혈압 및 ALT와의 상관관계를 보았을 때 모든 인자들의 수치가 증가할수록 GGT의 농도가 유의하게 증가하였고, GGT를 0～19 IU/L, 20～39 IU/L, 40～59 IU/L, 60 IU/L 이상의 4군으로 분류했을 때 당뇨병 및 공복혈당장애 유병율 및 비교위험도는 증가하였다. 또한 나이 30세 이상, 체질량지수 27 kg/m2 미만, 총 콜레스테롤 150 mg/dL 이상, 수축기 혈압 160 mmHg 미만, 이완기 혈압 90 mmHg 미만 및 ALT 36 IU/L 미만일 경우에는 GGT가 증가할수록 당뇨병 유병율이 증가하였다. 결론 : GGT와 당뇨병 유병율 사이에는 상관관계가 있었으며 특히 나이 30세 이상, 체질량지수 27 kg/m2 미만, 총 콜레스테롤 150 mg/dL 이상, 수축기 혈압 160 mmHg 미만, 이완기 혈압 90 mmHg 미만 및 ALT 36 IU/L 미만일 경우 상관관계가 뚜렷하였다. 이는 GGT 수치가 당뇨병 발생 가능성의 지표로 사용될 수 있다는 것을 시사한다.
Abstract
Background : Gamma-glutamyltransferase (GGT), which is an intracellular antioxidant due to maintain intracellular concentrations of glutathione, may be a marker of oxidative stress. In the present study, oxidative stress was thought to be a cause of diabetes mellitus. So, We performed a cross sectional study about the relations between GGT and prevalence of diabetes mellitus. Methods : In total 5049 healthy men who had visited the Yonsei Wonju Christian Hospital for health care from 1st January 2002 to 31st December 2002, we measured BMI, blood pressure, GGT, total cholesterol, ALT and fasting blood sugar levels. Results : There were strong relations between serum GGT concentrations and age, BMI, total cholesterol, systolic blood pressure, diastolic blood pressure and ALT level. GGT level had positive correlations with the prevalence of diabetes mellitus and impaired glucose tolerance when divided into four classes, 0～19 IU/L, 20～39 IU/L, 40～59 IU/L and over 60 IU/L. We got the same results after adjustment with BMI, total cholesterol, blood pressure and ALT level. Conclusion : There was a positive correlation between GGT level and the prevalence of diabetes mellitus, and that was definite especially when BMI, total cholesterol, blood pressure and ALT levels were in normal range. We suggest that serum GGT level would be an important marker in the development of diabetes mellitus.
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