규칙적인 유산소 운동이 HMW adiponectin 농도에 미치는 영향
Effects of Regular Aerobic Exercise on HMW adiponectin Concentration
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초록
이 연구는 12주간의 유산소성 운동이 비만 중년여성의 혈중 HMW adiponectin 농도에 미치는 영향을 알아보는 것이었다. 피험자는 40-60세의 비만 중년여성 46명으로 하였으며, 최대산소섭취량의 50～60%로 주 3회 12주간 걷기 운동을 실시하였다. 본 연구의 결과 비만 지표, 대사증후군 지표, 인슐린저항성 지표, 심폐체력 모두 규칙적인 운동을 통하여 개선되는 것으로 나타났다. 또한 12주 유산소성 운동에 의한 측정변인들의 변화 값에 대한 상관관계를 살펴본 결과 HMW adiponectin은 글루코스, 유리지방산과의 음의 상관관계가 나타났으며, HMW adiponectin의 변량 예측을 위한 다중회귀분석 결과 HMW adiponectin의 변량을 예측할 수 있는 인자로 총아디포넥틴과 더불어 유리지방산이 동반된 설명력이 약 43.4%(p=.009)를 갖는 것으로 나타났다. 결론적으로 규칙적인 유산소성 신체 트레이닝은 심폐체력의 향상과 함께 글루코스와 유리지방산의 개선 및 인슐린저항성을 개선시키고, 체지방의 감소와 더불어 여러 가지 대사적 변인들과 상관관계를 가짐으로서 궁극적으로 HMW adiponectin의 발현량을 증가시키는 것으로 사료된다.
Abstract
Adiponectin plays an important role in the modulation of glucose and lipid metabolism. The current study analyzed the effects of 12 weeks aerobic exercise in serum total adiponectin, HMW adiponectin, cardiorespiratory fitness, insulin resistance, obesity, and metabolic risk factors in 46 obese [body mass index (in kg/m2): ≥25; waist circumference >80 cm] middle aged women. The subject performed aerobic exercise program (3days/wk) involved walking at an intensity of 50-60% of VO2max for 12 weeks. Measured variables of the study include obesity and metabolic syndrome markers, including blood pressures, lipid profiles, fasting glucose and insulin, serum total adiponectin and HMW adiponectin. These variables measured at baseline and following the intervention program. After 12 weeks aerobic exercise program, obese indices, metabolic risk factors, blood pressures, lipid profiles, HOMA-IR and HMW adiponectin were significantly improved. Changes in HMW adiponectin were associated with changes in glucose(r=-.292, p<.05) and free fatty acid(r=-.489, p<.01). In stepwise multiple regression analysis, decreased free fatty acid(p<.001) and glucose(p=.040) were independent predictors of the changes in HMW adiponectin. In conclusion, the findings of the study show that regular aerobic exercise training significantly decrease glucose and free fatty acid and improve insulin resistance. And increase in HMW adiponectin expression was associated with both % body fat loss and improvement in metabolic indices.
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