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In Vivo Disease Control Efficacy of Isoquinoline Alkaloids Isolated from Corydalis ternata against Wheat Leaf Rust and Pepper Anthracnose

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주제분류생물학

초록

Phytochemicals have been considered as alternatives for synthetic fungicides because of their biodegradability and low toxicity. In this study, we found that the methanolic extract of Corydalis ternata suppressed the development of plant diseases caused by Puccinia triticina and Colletotrichum coccodes. As the antifungal substance, three isoquinoline alkaloids (dehydrocorydaline, stylopine, and corydaline) were isolated from C. ternata. These active compounds also exhibited in vivo antifungal activity against P. triticina and C. coccodes. Taken together, our results suggest that C. ternata and its active compounds can be used to control plant diseases.

Abstract

Phytochemicals have been considered as alternatives for synthetic fungicides because of their biodegradability and low toxicity. In this study, we found that the methanolic extract of Corydalis ternata suppressed the development of plant diseases caused by Puccinia triticina and Colletotrichum coccodes. As the antifungal substance, three isoquinoline alkaloids (dehydrocorydaline, stylopine, and corydaline) were isolated from C. ternata. These active compounds also exhibited in vivo antifungal activity against P. triticina and C. coccodes. Taken together, our results suggest that C. ternata and its active compounds can be used to control plant diseases.

참고문헌 (27)

  1. Oerke EC, "Crop losses to pests", J. Agric. Sci., 144, pp.31~43 (2006)[DOI]
  2. Wightwick A, "Environmental risks of fungicides used in horticultural production systems;Fungicides", pp.273~304 (2010), InTech
  3. Gisi U, "Recent developments in elucidating modes of resistance to phenylamide, DMI and strobilurin fungicides", Crop. Prot., 19, pp.863~872 (2000)[DOI]
  4. Dang QL, "Antimicrobial activities of novel mannosyl lipids isolated from the biocontrol fungus Simplicillium lamellicola BCP against phytopathogenic bacteria", J. Agric. Food Chem., 62, pp.3363~3370 (2014)[DOI]
  5. Vu TT, "In vitro antibacterial activity of selected medicinal plants traditionally used in Vietnam against human pathogenic bacteria", BMC Complement. Altern. Med., 16, pp.32~37 (2016)
  6. Bednarek P, "Plant-microbe interactions: chemical diversity in plant defense", Science, 324, pp.746~748 (2009)[DOI]
  7. Dayan FE, "Natural products in crop production", Bioorg. Med. Chem., 17, pp.4022~4034 (2009)[DOI]
  8. Lee KJ, "Molecular application to identify Corydalis tubers", Planta Med., 78, pp.OP15~ (2012)
  9. Kim KH, "Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity", Bioorg. Med. Chem. Lett., 20, pp.4487~4490 (2010)[DOI]
  10. Lee HY, "Isolation and quantitative determination of berberine and coptisine from tubers of Corydalis ternata", Kor. J. Pharmacogn., 30, pp.332~334 (1999)
  11. Kim SR, "Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities", Planta Med., 65, pp.218~221 (1999)[DOI]
  12. 서원세, "Aldose Reductase Inhibitory Alkaloids from Corydalis ternata", Natural Product Sciences, 22(2), pp.102~106 (2016), 한국생약학회
  13. Kim MK, "Fungicidal property of Curcuma longa L. rhizome-derived curcumin against phytopathogenic fungi in a greenhouse", J. Agric. Food Chem., 51, pp.1578~1581 (2003)
  14. CHO, JUN-YOUNG, "Antifungal Activity Against Colletotrichum spp. of Curcuminoids Isolated from Curcuma longa L. Rhizomes", Journal of Microbiology and Biotechnology, 16(2), pp.280~285 (2006), 한국미생물·생명공학회
  15. Hughes DW, "TEX>$^{13}C$<", TEX> magnetic resonance spectra of some isoquinoline alkaloids and related model compounds, 1976, pp.54, 2252~2260
  16. Dai-Ho G, "Exploratory, mechanistic, and synthetic aspects of silylarene-iminium salt SET photochemistry. Studies of diradical cyclization processes and applications to protoberberine alkaloid synthesis", J. Org. Chem., 53, pp.5113~5127 (1988)[DOI]
  17. Janssen RH, "Assignments of <TEX>$^{1}H$<", TEX> and <TEX>$^{13}C$<, Phytochemistry, pp.1990, 29[DOI]
  18. Ton g S, "Preparative i solation and purification of alkaloids from Corydalis yanhusuo W. T. Wang by high speed counter-current chromatography", J. Liq. Chromatogr. Relat. Technol., 28, pp.2979~2989 (2005)
  19. Liu M, "Identification of multiple constituents in Chinese medicinal prescription Shensong Yangxin capsule by ultra-fast liquid chromatography combined with quadrupole time-of-flight mass spectrometry", J. Chromatogr. Sci., 53, pp.240~252 (2014)
  20. Jesionek W, "Investigation of the composition and antibacterial activity of Ukrain drug using liquid chromatography techniques", J. Chromatogr. A, 1429, pp.340~347 (2016)[DOI]
  21. Orhan I, "Antiviral and antimicrobial profiles of selected isoquinoline alkaloids from Fumaria and Corydalis species", Z. Naturforsch. C, 62, pp.19~26 (2007)
  22. Ma W, "Fungitoxic alkaloids from Hokkaido Corydalis species", Fitoterapia, 70, pp.258~265 (1999)[DOI]
  23. Maurya S, "Effect of tetrahydropalmatine, an alkaloid, on spore germination of some fungi", Mycobiology, 29, pp.142~144 (2001)
  24. Singh NV, "Two plant alkaloids isolated from Corydalis longipes as potential antifungal agents", Folia Microbiol., 48, pp.605~609 (2003)[DOI]
  25. Iranshahy M, "Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis", RSC Adv., 4, pp.15900~15913 (2014)[DOI]
  26. Hu J, "Alkaloids from Toddalia asiatica and their cytotoxic, antimicrobial and antifungal activities", Food Chem., 148, pp.437~444 (2014)[DOI]
  27. da Silva AR, "Berberine antifungal activity in fluconazole-resistant pathogenic yeasts: action mechanism evaluated by flow cytometry and biofilm growth inhibition in Candida spp", Antimicrob. Agents Chemother., 60, pp.3551~3557 (2016)[DOI]

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