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Inhibitory Components from Glycosmis stenocarpa on Pepper Mild Mottle Virus

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초록

The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.

Abstract

The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.

참고문헌 (11)

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  4. Kim JH, "Inhibition of soluble epoxide hydrolase activity by compounds isolated from the aerial parts of Glycosmis stenocarpa", J. Enzyme Inhib. Med. Chem, 31, pp.640~644 (2015)
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  11. Xiao J-J, "Design, synthesis and anti-tobacco mosaic virus(TMV)activity of 5-chloro-N-(4-cyano-1-aryl-1H-pyrazol-5-ly)-1-aryl-3-methyl-1H-pyrazole-4-carboxamide derivatives", Molecules, 20, pp.807~821 (2015)

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