Inhibitory Components from Glycosmis stenocarpa on Pepper Mild Mottle Virus
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The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.
Abstract
The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.
참고문헌 (11)
- Antignus Y, "A new pathotype of pepper mild mottle virus (PMMoV)overcomes the L4resistance genotype of pepper cultivars", Plant Dis, 92, pp.1033~1037 (2008)
- Chen J, "Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Been", J. Agric. Food Chem, 57, pp.6590~6595 (2009)
- Itoigawa M, "Antitumor agents, 203, carbazole alkaloid murrayaquinone A and related synthetic carbazole quinones as cytotoxic agents", J. Nat. Prod, 63, pp.893~897 (2000)
- Kim JH, "Inhibition of soluble epoxide hydrolase activity by compounds isolated from the aerial parts of Glycosmis stenocarpa", J. Enzyme Inhib. Med. Chem, 31, pp.640~644 (2015)
- Kim M-K, "Molecular genetic analysis of cucumber mosaic virus population infecting pepper suggests unique patterns of evolution in Korea", Virology, 104, pp.993~1000 (2014)
- Oka N, "Inhibition of pepper mild mottle virus with commercial cellulases", J. Phytopathol, 156, pp.65~67 (2007)
- Petrov N, "Effect of pepper mild mottle virus infection on pepper and tomato plants", Sci. Technol, 4, pp.61~64 (2014)
- Reddy UK, "Identification of gene-specific polymorphisms and association with capsaicin pathway metabolites in Capsicum annuum L. collections", PLoS One, 9, pp.e86393~ (2014)
- Reisch J, "Carbazole alkaloids from seeds of Murray koenigii", Phytochemistry, 31, pp.2877~2879 (1992)
- Son M-J, "Alterations of contractions and L-type Ca2+ currents by murrayafoline-A rat ventricular myocytes", Eur. J. Pharmacol, 740, pp.81~87 (2014)
- Xiao J-J, "Design, synthesis and anti-tobacco mosaic virus(TMV)activity of 5-chloro-N-(4-cyano-1-aryl-1H-pyrazol-5-ly)-1-aryl-3-methyl-1H-pyrazole-4-carboxamide derivatives", Molecules, 20, pp.807~821 (2015)
