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The Association between Serum Uric Acid Level and Incidence of Metabolic Syndrome according to Menopausal Status in Korean Women

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The aim of this study is to investigate the association between serum uric acid level and metabolic syndromeaccording to menopausal status in Korean women. Methods: A total of 2,241 women who visited to the health promotion center at Pusan National University Hospital from 2010 to2014 were included in this cross-sectional study. Self-report questionnaires and interviews with healthcare providers were usedto assess disease history, medication history, menstrual history and body size measuring. Anthropometric measurements andlaboratory results were compared as presence of metabolic syndrome and menopausal status by student-t test. Logistic regressionanalysis was performed between presence of metabolic syndrome and presumable predictive factors, such as age, menopauseand serum uric acid. Results: The prevalence rate of metabolic syndrome were 7.45% (63/846) in pre-menopausal group and 23.87% (333/1395) inmenopausal group. Serum uric acid level was higher in menopausal women than premenopausal women (4.6 ± 1.1 vs. 4.3 ± 0.9. P = 0.000). And, its concentration was also higher in metabolic syndrome than normal women regarding of menopausal statue(premenopause 4.7 ± 1.1 vs. 4.2 ± 0.8, P = 0.001, menopause 4.9 ± 1.3 vs. 4.5 ± 1.0, P = 0.000). Multiple logistic regression analysisshowed serum uric acid and age have relationship with metabolic syndrome (OR: 1.453, 95% confidence interval [CI]: 1.074-1.111,P = 0.000; OR: 1.092, 95% CI: 1.305-1.619, P = 0.000). Conclusion: We could find out some potential of uric acid as predictive factor for metabolic syndrome in premenopausal andmenopausal group. Further investigation is required to clarify the relationship between serum uric acid, menopause and metabolicsyndrome. (J Menopausal Med 2014;20:126-132)

Abstract

The aim of this study is to investigate the association between serum uric acid level and metabolic syndromeaccording to menopausal status in Korean women. Methods: A total of 2,241 women who visited to the health promotion center at Pusan National University Hospital from 2010 to2014 were included in this cross-sectional study. Self-report questionnaires and interviews with healthcare providers were usedto assess disease history, medication history, menstrual history and body size measuring. Anthropometric measurements andlaboratory results were compared as presence of metabolic syndrome and menopausal status by student-t test. Logistic regressionanalysis was performed between presence of metabolic syndrome and presumable predictive factors, such as age, menopauseand serum uric acid. Results: The prevalence rate of metabolic syndrome were 7.45% (63/846) in pre-menopausal group and 23.87% (333/1395) inmenopausal group. Serum uric acid level was higher in menopausal women than premenopausal women (4.6 ± 1.1 vs. 4.3 ± 0.9. P = 0.000). And, its concentration was also higher in metabolic syndrome than normal women regarding of menopausal statue(premenopause 4.7 ± 1.1 vs. 4.2 ± 0.8, P = 0.001, menopause 4.9 ± 1.3 vs. 4.5 ± 1.0, P = 0.000). Multiple logistic regression analysisshowed serum uric acid and age have relationship with metabolic syndrome (OR: 1.453, 95% confidence interval [CI]: 1.074-1.111,P = 0.000; OR: 1.092, 95% CI: 1.305-1.619, P = 0.000). Conclusion: We could find out some potential of uric acid as predictive factor for metabolic syndrome in premenopausal andmenopausal group. Further investigation is required to clarify the relationship between serum uric acid, menopause and metabolicsyndrome. (J Menopausal Med 2014;20:126-132)

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