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한국 성인의 혈청 요산 수치와 인슐린저항성 및 대사증후군 구성요소간의 연관성

Relationship between Serum Uric Acid Levels, Insulin Resistance and Components of Metabolic Syndrome in Korean Adults

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초록

본 연구는 한국 성인의 성별에 따른 혈청 요산 수치와 인슐린저항성 및 대사증후군 구성요소간의 관련성을 확인하고자 하였다. 2018년 6월에서 2020년 5월 사이에 경기지역 종합병원에서 건강검진을 받았던 20세 이상 남성 2,365명, 여성 2,063명 총 4,428명을 대상으로 단면연구를 시행하였다. 연구결과 남녀 모두 정상군보다 대사증후군 진단군에서 요산치가 높았으며, 고요산혈증군에서 대사증후군과 그 구성요소의 발병률은 정상군보다 높았다. 고요산혈증은 남성에서 혈압상승(p=0.006)과 고중성지방혈증(p<0.001), 여성에서 대사증후군(p=0.012)과 낮은 HDL-콜레스테롤(p<0.001) 발병 위험을 높이는 요인으로 나타났다. 따라서 남성과 여성 모두에서 고요산혈증은 대사증후군 및 그 구성요소와 관련이 있었으며, 특히 여성에서 대사증후군 발병의 독립적인 예측인자임을 확인하였다

Abstract

The purpose of this study was to investigate the relationship between serum uric acid levels, insulin resistance and components of metabolic syndrome. It was conducted on 4,428 adults over the age of 20 who had undergone health checkups at a general hospital in Gyeonggi-do from June 2018 to May 2020. As a result of the study, uric acid levels were higher in the metabolic syndrome subjects than normal subjects in both men and women. and the incidence of metabolic syndrome and its components was higher in the hyperuricemia group than in the normal group. Hyperuricemia was found to increase the risk of elevated blood pressure(p=0.006) and hypertriglyceridemia(p<0.001) in men and metabolic syndrome(p=0.012) and low HDL-cholesterol(p<0.001) in women. Thus, in both men and women, hyperuricemia was associated with metabolic syndrome and its components, and it was confirmed that it was an independent predictor of the onset of metabolic syndrome in women.

참고문헌 (42)

  1. Y. He, "Prevalence of the metabolic syndrome and its relation to cardiovascular disease in an elderly Chinese population", Journal of the American College of Cardiology, 47(8), pp.1588~1594 (2006)[DOI]
  2. 김민현, "한국 성인에서 10년간 대사증후군 유병률과 위험요인의 변화: 국민건강영양조사(2008–2017) 자료를 이용하여", Korean Journal of Family Practice, 10(1), pp.44~52 (2020), 대한가정의학회[DOI]
  3. B. Isomaa, "Cardiovascular morbidity and mortality associated with the metabolic syndrome", Diabetes Care, 24(4), pp.683~689 (2001)[DOI]
  4. A. Galassi, "Metabolic syndrome and risk of cardiovascular disease : a meta-analysis", American Journal of Medicine, 119(10), pp.812~819 (2006)[DOI]
  5. E. S. Ford, "Metabolic syndrome and risk of incident diabetes : findings from the European Prospective Investigation into Cancer and Nutrition-Potsdam Study", Cardiovascular Diabetology, 12(7), pp.35~ (2008)[DOI]
  6. K. Esposito, "Metabolic syndrome and risk of cancer : a systematic review and meta-analysis", Diabetes Care, 35(11), pp.2402~2411 (2012)[DOI]
  7. J. Zhou, "Association between metabolic syndrome and osteoporosis : a meta-analysis", Bone, 57(1), pp.30~35 (2013)[DOI]
  8. T. W. Yoo, "Relationship between serum uric acid concentration and insulin resistance and metabolic syndrome", Circulation Journal, 69(8), pp.928~933 (2005)[DOI]
  9. B. Liu, "The prevalence of hyperuricemia in China : a meta-analysis", BioMed Central Public Health, 27(11), pp.832~ (2011)[DOI]
  10. E. S. Ford, "Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents", Circulation, 15(19), pp.2526~2532 (2007)[DOI]
  11. V. Guarner, "Low-grade systemic inflammation connects aging, metabolic syndrome and cardiovascular disease", Interdisciplinary Topics in Gerontology, 40, pp.99~106 (2015)[DOI]
  12. S. Furukawa, "Increased oxidative stress in obesity and its impact on metabolic syndrome", Journal of Clinical Investigation, 114(12), pp.1752~1761 (2004)[DOI]
  13. J. Fang, "Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey", Journal of the American Medical Association, 283(18), pp.2404~2410 (2000)[DOI]
  14. M. J. Bos, "Uric acid is a risk factor for myocardial infarction and stroke : the Rotterdam study", Stroke, 37(6), pp.1503~1507 (2006)[DOI]
  15. K. Nagahama, "Hyperuricemia and cardiovascular risk factor clustering in a screened cohort in Okinawa, Japan", Hypertension Research, 27(4), pp.227~233 (2004)[DOI]
  16. S. Ohno, "Recovery of Endothelial Function after Minor-to-Moderate Surgery Is Impaired by Diabetes Mellitus, Obesity, Hyperuricemia and Sevoflurane-Based Anesthesia", International Heart Journal, 59(3), pp.559~565 (2018)[DOI]
  17. Z. Soltani, "Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?", Current Hypertension Reports, 15(3), pp.175~181 (2013)[DOI]
  18. A. Costa, "Uric acid concentration in subjects at risk of type 2 diabetes mellitus : relationship to components of the metabolic syndrome", Metabolism, 51(3), pp.372~375 (2002)[DOI]
  19. A. Onat, "Serum uric acid is a determinant of metabolic syndrome in a population-based study", American Journal of Hypertension, 19(10), pp.1055~1062 (2006)[DOI]
  20. R. L. Borges, "Uric acid as a factor in the metabolic syndrome", Current Hypertension Reports, 12(2), pp.113~119 (2010)[DOI]
  21. 신경아, "Clinical Usefulness of Serum Uric Acid and Resting Heart Rate in the Diagnosis of Metabolic Syndrome in Korean Adults", 대한의생명과학회지, 23(2), pp.118~127 (2017), 대한의생명과학회[DOI]
  22. 홍승표, "성별에 따른 혈청 요산 농도와 대사증후군의 연관성", Korean Circulation Journal, 38(3), pp.152~160 (2008), 대한심장학회
  23. E. Adnan, "Relationship between insulin resistance, metabolic syndrome components and serum uric acid", Diabetes & Metabolic Syndrome, 13(3), pp.2158~2162 (2019)[DOI]
  24. Ľ. Cibičková, "Correlation of uric acid levels and parameters of metabolic syndrome", Physiological Research, 66(3), pp.481~487 (2017)[DOI]
  25. D. R. Matthews, "Homeostasis model assessment : insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28(7), pp.412~419 (1985)[DOI]
  26. 이시훈, "Cutoff Values of Surrogate Measures of Insulin Resistance for Metabolic Syndrome in Korean Non-diabetic Adults", Journal of Korean Medical Science, 21(4), pp.695~700 (2006), 대한의학회
  27. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, "Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)", JAMA: The Journal of the American Medical Association, 285(19), pp.2486~2497 (2001), American Medical Association (AMA)[DOI]
  28. World Health Organization, "The Asia-Pacific perspective : redefining obesity and its treatment" (2000), Health Communications Australia
  29. H. Choi, "Serum uric acid concentration and metabolic syndrome among elderly Koreans: The Korean Urban Rural Elderly (KURE) study", Archives of Gerontology and Geriatrics, 64, pp.51~58 (2016)[DOI]
  30. L. B. Salaroli, "Insulin resistance and associated factors : a cross-sectional study of bank employees", Clinics(Sao Paulo, Brazil), 72(4), pp.224~230 (2017)[DOI]
  31. S. O. V. Nunes, "Genetic polymorphisms in glutathione-S-transferases are associated with anxiety and mood disorders in nicotine dependence", Psychiatric Genetics, 24(3), pp.87~93 (2014)[DOI]
  32. A. M. Johnson, "The origins and drivers of insulin resistance", Cell, 152(4), pp.673~684 (2013)[DOI]
  33. N. Ali, "Association between serum uric acid and metabolic syndrome : a cross-sectional study in Bangladeshi adults", Scientific Reports, 10(1), pp.7841~ (2020)[DOI]
  34. H. Sumiyoshi, "Association of uric acid with incident metabolic syndrome in a Japanese general population", International Heart Journal, 60(4), pp.830~835 (2019)[DOI]
  35. Y. Q. Fu, "Positive association between metabolic syndrome and serum uric acid in Wuhan", Asia Pacific Journal of Clinical Nutrition, 26(2), pp.343~350 (2017)[DOI]
  36. C. F. Kuo, "Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality", Rheumatology(Oxford), 52(1), pp.127~134 (2013)[DOI]
  37. S. Ciarla, "Serum uric acid levels and metabolic syndrome", Archives of Physiology and Biochemistry, 120(3), pp.119~122 (2014)[DOI]
  38. M. Abbasian, "Association between serum uric acid(SUA)levels and metabolic syndrome(MetS)components in personnel of Shahroud University of Medical Sciences", Diabetology & Metabolic Syndrome, 10(3), pp.132~136 (2016)[DOI]
  39. Z. Zhang, "Serum uric acid : a marker of metabolic syndrome and subclinical atherosclerosis in Korean men", Angiology, 63(6), pp.420~428 (2012)[DOI]
  40. G. Mercuro, "Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk", American Journal of Cardiology, 94(7), pp.932~935 (2004)[DOI]
  41. G. Wu, "Nitric oxide and vascular insulin resistance", Biofactors, 35(1), pp.21~27 (2009)[DOI]
  42. R. Meshkani, "The relationship between uric acid and metabolic syndrome in normal glucose tolerance and normal fasting glucose subjects", Acta Diabetologica, 48(1), pp.79~88 (2011)[DOI]

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