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일부 중년여성에서의 혈청요산농도와 대사증후군의 관련성

Association of the Level of Serum Uric Acid and Metabolic Syndrome in Middle-aged Women

김성희|김종연|박정한|이혜미
한국모자보건학회 (The Korean Society Of Maternal And Child Health)|2009.07|한국모자보건학회지 (JOURNAL OF KOREAN MATERNAL AND CHILD HEALTH)|제13권 제2호|pp. 182-194|DOI 10.21896/jksmch.2009.13.2.182

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참고문헌

키워드

metabolic syndromemenopausewomanuric acid
주제분류예방의학/직업환경의학

초록

Objectives: Hyperuricemia is known to be a risk factor for cardiovascular disease. The variables related to metabolic syndrome(MS), as well as other cardiovascular risk factors such as serum uric acid, differ according to gender. The study was performed to assess the relationship of serum uric acid (SUA) with metabolic syndrome in middle- aged healthy women and observed the patterns of those association in pre- and post- menopausal status. Methods: The 757 women aged over 40 years who had visit for Health examination were enrolled and divided into four groups (Quartile 1:1.7~3.6 mg/dL, Quartile 2:3.7~4.2 mg/dL, Quartile 3:4.3~4.8 mg/dL, Quartile 4:4.9~7.6 mg/dL) according to their SUA level. The blood pressure, lipid profiles, fasting serum glucose, waist circumference, high sensitivity CRP and apolipoprotein were compared between the four group. The MS was defined by the modified ATP III criteria. Results: The prevalence of MS was 16.8%. There was a positive association between SUA and component of MS excepting fasting serum glucose, respectively (p<0.001). After adjustment for covariates, the risk of women in the highest quartile of SUA (4.9~ 7.6 mg/dL) had 2.14 (95% CI: 1.16~3.97) fold increase in risk of MS as compared with those who were in the lowest quartile (1.7~3.6 mg/dL). and the same patterns were observed in pre-and post menopausal status. The association between SUA and MS observed more strangely in pre-menopausal status than post-menopausal status but interaction between SUA and menopausal status was not significant. Conclusion: Our study suggests that SUA levels were independently associated with metabolic syndrome. Although the SUA level was in the normal range, the risk of metabolic syndrome was increased with an elevated serum uric acid level. However, because of the cross-sectional nature of our study, these findings should be confirmed in prospective cohort studies.

Abstract

Objectives: Hyperuricemia is known to be a risk factor for cardiovascular disease. The variables related to metabolic syndrome(MS), as well as other cardiovascular risk factors such as serum uric acid, differ according to gender. The study was performed to assess the relationship of serum uric acid (SUA) with metabolic syndrome in middle- aged healthy women and observed the patterns of those association in pre- and post- menopausal status. Methods: The 757 women aged over 40 years who had visit for Health examination were enrolled and divided into four groups (Quartile 1:1.7~3.6 mg/dL, Quartile 2:3.7~4.2 mg/dL, Quartile 3:4.3~4.8 mg/dL, Quartile 4:4.9~7.6 mg/dL) according to their SUA level. The blood pressure, lipid profiles, fasting serum glucose, waist circumference, high sensitivity CRP and apolipoprotein were compared between the four group. The MS was defined by the modified ATP III criteria. Results: The prevalence of MS was 16.8%. There was a positive association between SUA and component of MS excepting fasting serum glucose, respectively (p<0.001). After adjustment for covariates, the risk of women in the highest quartile of SUA (4.9~ 7.6 mg/dL) had 2.14 (95% CI: 1.16~3.97) fold increase in risk of MS as compared with those who were in the lowest quartile (1.7~3.6 mg/dL). and the same patterns were observed in pre-and post menopausal status. The association between SUA and MS observed more strangely in pre-menopausal status than post-menopausal status but interaction between SUA and menopausal status was not significant. Conclusion: Our study suggests that SUA levels were independently associated with metabolic syndrome. Although the SUA level was in the normal range, the risk of metabolic syndrome was increased with an elevated serum uric acid level. However, because of the cross-sectional nature of our study, these findings should be confirmed in prospective cohort studies.

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