Uric Acid Level Has a J-Shaped Association with Arterial Stiffness in Korean Postmenopausal Women
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초록
Background: Uric acid has been reported to function both as an oxidant or antioxidant depending on the context. A previous study in the Korean population reported a positive linear association between serum uric acid level andarterial stiffness in men, but little is known about how serum uric acid level is related to the risk of increased arterialstiffness in Korean postmenopausal women. Methods: We performed a cross-sectional study of 293 subjects who participated in a health examination programrun by the health promotion center of Gangnam Severance Hospital between October 2007 and July 2010. Highbrachial-ankle pulse wave velocity was defined as a brachial-ankle pulse wave velocity of more than 1,450 cm/s. The odds ratios (ORs) for high brachial-ankle pulse wave velocity were calculated using multivariate logistic regressionanalysis across uric acid quartiles after adjusting for other indicators of cardiovascular risk. Results: The 293 postmenopausal women were divided into quartiles according to uric acid level. The mean brachial-ankle pulse wave velocity values of each quartile were as follows: Q1, 1,474 cm/s; Q2, 1,375 cm/s; Q3, 1,422cm/s; Q4, 1,528 cm/s. The second quartile was designated as the control group based on mean brachial-anklepulse wave velocity value. Multivariate adjusted ORs (95% confidence intervals) for brachial-ankle pulse wave velocityacross the uric acid quartiles were 2.642 (Q1, 1.095–6.3373), 1.00, 4.305 (Q3, 1.798–10.307), and 4.375 (Q4,1.923–9.949), after adjusting for confounding variables. Conclusion: Serum uric acid level has a J-shaped association with arterial stiffness in Korean postmenopausalwomen.
Abstract
Background: Uric acid has been reported to function both as an oxidant or antioxidant depending on the context. A previous study in the Korean population reported a positive linear association between serum uric acid level andarterial stiffness in men, but little is known about how serum uric acid level is related to the risk of increased arterialstiffness in Korean postmenopausal women. Methods: We performed a cross-sectional study of 293 subjects who participated in a health examination programrun by the health promotion center of Gangnam Severance Hospital between October 2007 and July 2010. Highbrachial-ankle pulse wave velocity was defined as a brachial-ankle pulse wave velocity of more than 1,450 cm/s. The odds ratios (ORs) for high brachial-ankle pulse wave velocity were calculated using multivariate logistic regressionanalysis across uric acid quartiles after adjusting for other indicators of cardiovascular risk. Results: The 293 postmenopausal women were divided into quartiles according to uric acid level. The mean brachial-ankle pulse wave velocity values of each quartile were as follows: Q1, 1,474 cm/s; Q2, 1,375 cm/s; Q3, 1,422cm/s; Q4, 1,528 cm/s. The second quartile was designated as the control group based on mean brachial-anklepulse wave velocity value. Multivariate adjusted ORs (95% confidence intervals) for brachial-ankle pulse wave velocityacross the uric acid quartiles were 2.642 (Q1, 1.095–6.3373), 1.00, 4.305 (Q3, 1.798–10.307), and 4.375 (Q4,1.923–9.949), after adjusting for confounding variables. Conclusion: Serum uric acid level has a J-shaped association with arterial stiffness in Korean postmenopausalwomen.
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