Serum Uric Acid Level and the Incidence of Metabolic Syndrome in Middle-aged Korean Men: A 5-Year Follow-up Study
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: Elevated serum uric acid (UA) has been known to be associated with the prevalence of metabolic syndrome (MetS). However,no prospective studies have examined whether serum UA levels are actually associated with the development of MetS. We performeda prospective study to evaluate the longitudinal effects of baseline serum UA levels on the development of MetS. Methods: A MetS-free cohort of 14 906 healthy Korean men, who participated in a medical check-up program in 2005, was followed until 2010. MetS was defined according to the Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiologyand Prevention. Cox proportional hazards models were performed. Results: During 52 466.1 person-years of follow-up, 2428 incident cases of MetS developed between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% confidence intervals) for incident MetS for the second, the third, and the fourth quartile to the first quartile of serum UA levels were 1.09 (0.92-1.29), 1.22 (1.04-1.44), and 1.48 (1.26-1.73), respectively (p for trend <0.001). These associations were also significant in the clinically relevant subgroup analyses. Conclusions: Elevated serum UA levels were independently associated with future development of MetS in Korean men during the 5-year follow-up period.
Abstract
Objectives: Elevated serum uric acid (UA) has been known to be associated with the prevalence of metabolic syndrome (MetS). However,no prospective studies have examined whether serum UA levels are actually associated with the development of MetS. We performeda prospective study to evaluate the longitudinal effects of baseline serum UA levels on the development of MetS. Methods: A MetS-free cohort of 14 906 healthy Korean men, who participated in a medical check-up program in 2005, was followed until 2010. MetS was defined according to the Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiologyand Prevention. Cox proportional hazards models were performed. Results: During 52 466.1 person-years of follow-up, 2428 incident cases of MetS developed between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% confidence intervals) for incident MetS for the second, the third, and the fourth quartile to the first quartile of serum UA levels were 1.09 (0.92-1.29), 1.22 (1.04-1.44), and 1.48 (1.26-1.73), respectively (p for trend <0.001). These associations were also significant in the clinically relevant subgroup analyses. Conclusions: Elevated serum UA levels were independently associated with future development of MetS in Korean men during the 5-year follow-up period.
참고문헌 (28)
- Suh S, "Metabolic syndrome and cardiovascular diseases in Korea", J Atheroscler Thromb, 21(Suppl 1), pp.S31~S35 (2014)
- Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, "Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)", JAMA, 285(19), pp.2486~2497 (2001)
- Kang YH, "Comparison of alanine aminotransferase, white blood cell count, and uric acid in their association with metabolic syndrome: a study of Korean adults", Endocr J, 55(6), pp.1093~1102 (2008)
- So A, "Uric acid transport and disease", J Clin Invest, 120(6), pp.1791~1799 (2010)
- Osgood K, "Serum uric acid predicts both current and future components of the metabolic syndrome", Metab Syndr Relat Disord, 11(3), pp.157~162 (2013)
- Ryu S, "Incidence and risk factors for metabolic syndrome in Korean male workers, ages 30 to 39", Ann Epidemiol, 17(4), pp.245~252 (2007)
- Choe JY, "Change in serum uric acid between baseline and 1-year follow-up and its associated factors in male subjects", Clin Rheumatol, 27(4), pp.483~489 (2008)
- Ryu S, "A cohort study of hyperuricemia in middle-aged South Korean men.", Am J Epidemiol, 175(2), pp.133~143 (2012)
- Matthews DR, "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28(7), pp.412~419 (1985)
- Levey AS, "A new equation to estimate glomerular filtration rate", Ann Intern Med, 150(9), pp.604~612 (2009)
- Alberti KG, "Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity", Circulation, 120(16), pp.1640~1645 (2009)
- Hara S, "High serum uric acid level and low urine pH as predictors of metabolic syndrome: a retrospective cohort study in a Japanese urban population", Metabolism, 61(2), pp.281~288 (2012)
- Yang T, "Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study", Atherosclerosis, 220(2), pp.525~531 (2012)
- Goncalves JP, "Cross-sectional and longitudinal associations between serum uric acid and metabolic syndrome", Endocrine, 41(3), pp.450~457 (2012)
- Zhang Q, "A longitudinal cohort based association study between uric acid level and metabolic syndrome in Chinese Han urban male population", BMC Public Health, 12, pp.419~ (2012)
- Oda E, "Serum uric acid is an independent predictor of metabolic syndrome in a Japanese health screening population", Heart Vessels, 29(4), pp.496~503 (2014)
- Wu XW, "Two independent mutational events in the loss of urate oxidase during hominoid evolution", J Mol Evol, 34(1), pp.78~84 (1992)
- Kanbay M, "The role of uric acid in the pathogenesis of human cardiovascular disease", Heart, 99(11), pp.759~766 (2013)
- Billiet L, "Review of hyperuricemia as new marker for metabolic syndrome", ISRN Rheumatol, 2014, pp.852~954 (2014)
- Masuo K, "Serum uric acid and plasma norepinephrine concentrations predict subsequent weight gain and blood pressure elevation", Hypertension, 42(4), pp.474~480 (2003)
- Nakanishi N, "Serum uric acid and risk for development of hypertension and impaired fasting glucose or type II diabetes in Japanese male office workers", Eur J Epidemiol, 18(6), pp.523~530 (2003)
- Shankar A, "The association between serum uric acid level and long-term incidence of hypertension: population-based cohort study", J Hum Hypertens, 20(12), pp.937~945 (2006)
- Perlstein TS, "Uric acid and the development of hypertension: the normative aging study", Hypertension, 48(6), pp.1031~1036 (2006)
- Dehghan A, "High serum uric acid as a novel risk factor for type 2 diabetes", Diabetes Care, 31(2), pp.361~362 (2008)
- Rathmann W, "Relations of hyperuricemia with the various components of the insulin resistance syndrome in young black and white adults: the CARDIA study: coronary artery risk development in young adults", Ann Epidemiol, 8(4), pp.250~261 (1998)
- Zhang ML, "Serum uric acid and appropriate cutoff value for prediction of metabolic syndrome among Chinese adults", J Clin Biochem Nutr, 52(1), pp.38~42 (2013)
- Garber CE, "American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise", Med Sci Sports Exerc, 43(7), pp.1334~1359 (2011)
- "2008 Physical activity guidelines for Americans" (2008)[URL]