한국인에서 β3AR, UCP2 유전자의 다형성과 체질량지수의 관련성
Association Analyses of β3AR Trp64Arg and UCP-2 -866G/A Polymorphisms with Body Mass Index in Korean
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Background：Obesity is the most common nutritional disorder in Western society as well as in Korea. Obesity results from a combination of genetic, environmental, and behavioral factors. Materials and Methods：In an attempt to investigate the association of obesity with its candidate genes, β3 adrenergic receptor (β3AR) and uncoupling protein 2 (UCP2), we analyzed polymorphisms of β3AR Trp64Arg and UCP2 -866G/A by PCR-RFLP analysis and the obesity-related phenotypes, including body mass index (BMI), fasting glucose concentration, and plasma lipid profiles in 750 subjects. 1) Results：The Trp64Arg polymorphism in the β3AR gene was not statistically associated with the BMI. The UCP2 -866G/A polymorphism was significantly higher in obese than in non-obese subjects (P<0.05). However, the UCP2 -866A/A polymorphism was higher in the non-obese subjects. Conclusion：These results suggest that the UCP2 -866G/A polymorphism might be more useful for the prediction of obesity and obesity-associated diseases in Korean patients than the β3AR Trp64Arg polymorphism.
Abstract
Background：Obesity is the most common nutritional disorder in Western society as well as in Korea. Obesity results from a combination of genetic, environmental, and behavioral factors. Materials and Methods：In an attempt to investigate the association of obesity with its candidate genes, β3 adrenergic receptor (β3AR) and uncoupling protein 2 (UCP2), we analyzed polymorphisms of β3AR Trp64Arg and UCP2 -866G/A by PCR-RFLP analysis and the obesity-related phenotypes, including body mass index (BMI), fasting glucose concentration, and plasma lipid profiles in 750 subjects. 1) Results：The Trp64Arg polymorphism in the β3AR gene was not statistically associated with the BMI. The UCP2 -866G/A polymorphism was significantly higher in obese than in non-obese subjects (P<0.05). However, the UCP2 -866A/A polymorphism was higher in the non-obese subjects. Conclusion：These results suggest that the UCP2 -866G/A polymorphism might be more useful for the prediction of obesity and obesity-associated diseases in Korean patients than the β3AR Trp64Arg polymorphism.