본문 바로가기
KERD
논문KCI 등재

비만의 유전학적 연구

Genetic Approach to Human Obesity

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류소아과학

초록

Increasing rate of childhood obesity is one of the social health problems in Korea. The mechanisms of fat accumulation and maintenance are not clear yet. Genetic, environmental, behavioral and socioeconomic factors in individuals might cause very heterogenous phenotypic expressions of obesity. In the aspect of genetic factors, there are two types of obesity; monogenic (single mutations) and polygenic obesity (known as common obesity). The completion of human genome project contributed to genetic study for obesity and many candidate genes associated with obesity were found in the past couple of years. However, the functional study of those genes was little performed. The trials to reveal the effect of each gene are required, because the more genes are studied, the better the mechanisms of obesity can be understood.

Abstract

Increasing rate of childhood obesity is one of the social health problems in Korea. The mechanisms of fat accumulation and maintenance are not clear yet. Genetic, environmental, behavioral and socioeconomic factors in individuals might cause very heterogenous phenotypic expressions of obesity. In the aspect of genetic factors, there are two types of obesity; monogenic (single mutations) and polygenic obesity (known as common obesity). The completion of human genome project contributed to genetic study for obesity and many candidate genes associated with obesity were found in the past couple of years. However, the functional study of those genes was little performed. The trials to reveal the effect of each gene are required, because the more genes are studied, the better the mechanisms of obesity can be understood.

참고문헌 (54)

  1. Bouchard C., "Current understanding of the etiology of obesity: genetic and nongenetic factors", Am J Clin Nutr, 통권 : 53, pp.1561S~1565S (1991)
  2. Carmelli D., "Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments?", Am J Hum Genet, 55, pp.566~573 (1994)
  3. Farooqi I.S., "Genetic and hereditary aspects of childhood obesity", Best Pract Res Clin Endocrinol Metab, 19, pp.359~374 (2005)
  4. Bell C.G., "The genetics of human obesity", Nat Rev Genet, 6, pp.221~234 (2005)
  5. Hunter D.J., "Gene-environment interactions in human diseases", Nat Rev Genet, 6, pp.287~298 (2005)
  6. Marti A., "Genetics of obesity: gene x nutrient interactions", Int J Vitam Nutr Res, 76, pp.184~193 (2006)
  7. Rankinen T., "The human obesity gene map: the 2005 update", Obesity (Silver Spring), 14, pp.529~644 (2006)
  8. Chung W.K., "Molecular physiology of syndromic obesities in humans", Trends Endocrinol Metab, 16, pp.267~272 (2005)
  9. Cl<TEX>$\acute{e}$<, "TEX>ment K.", Genetics of human obesity, 2005, pp.통권 : 64, 133~142
  10. Gunay-Aygun M., "The changing purpose of Prader- Willi syndrome clinical diagnostic criteria and proposed revised criteria", ediatrics, 108, pp.E92~ (2001)
  11. Horsthemke B., "Imprinting defects on human chromosome 15", Cytogenet Genome Res, 113, pp.292~299 (2006)
  12. Nicholls R.D., "Genome organization, function, and imprinting in Prader-Willi and Angelman syndromes", Annu Rev Genomics Hum Genet, 2, pp.153~175 (2001)
  13. Katsanis N., "Exploring the molecular basis of Bardet-Biedl syndrome", Hum Mol Genet, 10, pp.2293~2299 (2001)
  14. Collin G.B., "Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome", Nat Genet, 31, pp.74~78 (2002)
  15. Dereymaeker A.M., "The Borjeson-Forssman-Lehmann syndrome. A family study", Clin Genet, 29, pp.317~320 (1986)
  16. Lower K.M., "Mutations in PHF6 are associated with B<TEX>$\ddot{o}$<", TEX>rjeson-Forssman-Lehmann syndrome, 2002, pp.32, 661~665
  17. Kolehmainen J., "Cohen syndrome is caused by mutations in a novel gene, COH1, encoding a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport", Am J Hum Genet, 72, pp.1359~1369 (2003)
  18. Barsh GS, "Genetics of body- weight regulation", Nature, 404, pp.644~651 (2000)
  19. Farooqi I.S., "Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine", metabolic dysfunction of human congenital leptin deficiency, 2002, pp.110, 1093~1103
  20. Holder J.L., "Profound obesity associated with a balanced translocation that disrupts the SIM1 gene", Hum Mol Genet, 9, pp.101~108 (2000)
  21. Yeo G.S., "A de novo mutation affecting human TrkB associated with severe obesity and developmental delay", Nat Neurosci, 7, pp.1187~1189 (2004)
  22. Xu B., "Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor", Nat Neurosci, 6, pp.736~742 (2003)
  23. Huszar D., "Targeted disruption of the melanocortin-4 receptor results in obesity in mice", Cell, 88, pp.131~141 (1997)
  24. Farooqi I.S., "Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency", 106, pp.271~279 (2000)
  25. Lubrano-Berthelier C., "A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans", J Clin Endocrinol Metab, 89, pp.2028~2032 (2004)
  26. Dempfle A., "Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index", J Med Genet, 41, pp.795~800 (2004)
  27. Nijenhuis W.A., "AgRP (83- 132) acts as an inverse agonist on the human-melanocortin-4 receptor", Mol Endocrinol, 15, pp.164~171 (2001)
  28. Hager J., "A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10", Nat Genet, 20, pp.304~308 (1998)
  29. P<TEX>$\acute{e}$<, "TEX>russe L.", Gene-diet interactions in obesity, 2000, pp.통권 : 72, 1285S~1290S
  30. P<TEX>$\acute{e}$<, "TEX>russe L.", Genetics of obesity and metabolic complications in the Quebec Family Study, 2003, pp.19, 937~942
  31. Hebebrand J., "Perspectives: molecular genetic research in human obesity", Obes Rev, 4, pp.139~146 (2003)
  32. Arya R., "Evidence of a novel quantitative-trait locus for obesity on chromosome 4p in Mexican Americans", Am J Hum Genet, 74, pp.272~282 (2004)
  33. Bell C.G., "Genome-wide linkage analysis for severe obesity in french caucasians finds significant susceptibility locus on chromosome 19q", Diabetes, 53, pp.1857~1865 (2004)
  34. Snyder E.E., "The human obesity gene map: the 2003 update", Obes Res, 12, pp.369~439 (2004)
  35. Saar K., "Genome scan for childhood and adolescent obesity in German families", Pediatrics, 111, pp.321~327 (2003)
  36. Ichihara S., "Genetic factors for human obesity", Cell Mol Life Sci, 65, pp.1086~1098 (2008)
  37. Ristow M., "Obesity associated with a mutation in a genetic regulator of adipocyte differentiation", N Engl J Med, 339, pp.953~959 (1998)
  38. Deeb S.S., "A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity", Nat Genet, 20, pp.284~287 (1998)
  39. Meirhaeghe A., "The effect of the Gly16Arg polymorphism of the beta(2)-adrenergic receptor gene on plasma free fatty acid levels is modulated by physical activity", J Clin Endocrinol Metab, 86, pp.5881~5887 (2001)
  40. Masuo K., "Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years", Circulation, 111, pp.3429~3434 (2005)
  41. Corbal<TEX>$\acute{a}$<, "TEX>n M.S.", The 27Glu polymorphism of the beta2-adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects, 2002, pp.61, 305~307
  42. Cl<TEX>$\acute{e}$<, "TEX>ment K.", Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity, 1995, pp.333, 352~354
  43. Mitchell B.D., "A paired sibling analysis of the beta-3 adrenergic receptor and obesity in Mexican Americans", J Clin Invest, 101, pp.:584~587 (1998)
  44. Cl<TEX>$\acute{e}$<, "TEX>ment K.", Additive effect of A→G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3- adrenergic receptor gene on weight gain in morbid obesity, 1996, pp.20, 1062~1066
  45. Esterbauer H., "A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans", Nat Genet, 28, pp.178~183 (2001)
  46. Otabe S., "A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity", Diabetologia, 43, pp.245~249 (2000)
  47. Rosmond R., "G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion", J Clin Endocrinol Metab, 86, pp.2178~2180 (2001)
  48. Kritchevsky S.B., "Angiotensin- converting enzyme insertion", deletion genotype, exercise, and physical decline, 2005, pp.294, 691~698
  49. Yamada Y., "Genetic factors for obesity", Int J Mol Med, 18, pp.843~851 (2006)
  50. Siffert W, "Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals", J Am Soc Nephrol, 10, pp.1921~1930 (1999)
  51. Gutersohn A, "G protein beta3 subunit 825 TT genotype and post- pregnancy weight retention", Lancet, 355, pp.1240~1241 (2000)
  52. Hocher B., "Association of maternal G protein beta3 subunit 825T allele with low birthweight", Lancet, 355, pp.1241~1242 (2000)
  53. Mamm <TEX>$\grave{e}$<, "TEX>s O.", Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight, 2000, pp.64, 391~394
  54. Wauters M., "Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance", J Clin Endocrinol Metab, 86, pp.3227~3232 (2001)

관련 논문AI추천

이 간행물의 다른 논문 (12건)