소아기 단순 기침 환아에서의 케모카인 발현 양상 연구
Chemokines Expression in Children with a Non-productive Cough
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Purpose：To evaluate the chemokine expression in children with a non-productive cough. Materials and Methods：Six children with a non-productive cough who visited Yeungnam University Hospital were evaluated for the mRNA expression of interferon-γ-inducible protein 10(IP-10), macrophage cationic protein 1 and 3 (MCP-1, 3), interleukin (IL)-8, regulated upon activation in normal T cells expressed and secreted (RANTES), eotaxin and growth-related oncogene-α (Gro-α) using the reverse transcription polymerase chain reaction. Results：The chemokines IP-10 and MCP-3 were expressed in all samples. The chemokine RANTES was expressed in five cases, and IL-8 was expressed in three among them. However, eotaxin, Gro-α and MCP-1 were not expressed at all. The expression of chemokine MCP-3, RANTES and IL-8 were suppressed after the resolution of coughing in just one available case. Conclusion：The chemokines MCP-3, RANTES and IL-8 may contribute to airway inflammation in children with a non-productive cough, whereas IP-10 is of secondary importance in this condition.
Abstract
Purpose：To evaluate the chemokine expression in children with a non-productive cough. Materials and Methods：Six children with a non-productive cough who visited Yeungnam University Hospital were evaluated for the mRNA expression of interferon-γ-inducible protein 10(IP-10), macrophage cationic protein 1 and 3 (MCP-1, 3), interleukin (IL)-8, regulated upon activation in normal T cells expressed and secreted (RANTES), eotaxin and growth-related oncogene-α (Gro-α) using the reverse transcription polymerase chain reaction. Results：The chemokines IP-10 and MCP-3 were expressed in all samples. The chemokine RANTES was expressed in five cases, and IL-8 was expressed in three among them. However, eotaxin, Gro-α and MCP-1 were not expressed at all. The expression of chemokine MCP-3, RANTES and IL-8 were suppressed after the resolution of coughing in just one available case. Conclusion：The chemokines MCP-3, RANTES and IL-8 may contribute to airway inflammation in children with a non-productive cough, whereas IP-10 is of secondary importance in this condition.