비만인의 UCP-2 유전자 다형에 따른 운동 중 지방대사의 변화
Change of lipid metabolism during exercise according to UCP2 gene polymorphism in obesity man
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안의수, 이지영. 비만인의 UCP-2 유전자 다형에 따른 운동 중 지방대사의 변화. 운동과학, 14(1): 11-20, 2005. 본 연구의 목적은 UCP2 유전자 I/D 다형성에 따른 트레이드밀 운동 중 지질대사를 비교하는 것이었다. 본 연구의 피험자는 의학적 질환을 가지고 있지않은 총 39명(ID, n=10; DD, n=29; 연령 20-30대)으로 하였다. 신체계측은 신장, 체중, 체지방율을 측정하였고 운동부하 검사를 통해서 심폐체력을 측정하였다. 모든 피험자는 12시간 공복 후, 최대산소섭취량의 40% 강도로 한 시간 동안 운동하였다. 채혈은 전완정맥을 통해 안정 시, 운동 30분, 운동 60분, 그리고 회복기 1시간에 각각 채혈하였다. 채혈 후 혈중 젖산, 글루코스, 중성지방, 그리고 유리지방산을 분석하였다. 그리고 호흡교환율은 안정 시를 포함하여 운동 10분마다 측정하였다. 측정변인의 Two way ANOVA 결과, 혈중 젖산에서 집단과 반복 간에 유의한 상호작용이 나타났다. 그리고 유전형질 간의 비교에서 안정 시 중성지방과 젖산 농도는 DD 동형접합자 집단이 ID 이형접합자 집단보다 유의하게 높게 나타났다. 본 연구에서 나타난 결과로 볼 때, 비록 UCP2 유전자 다형에 따른 운동 중 지질대사에 영향을 미치지 않는 것으로 보이지만, UCP2 유전자 다형은 비만과 심혈관질환의 유전적 지표가 될 수 있음을 의미할 것이다.
Abstract
Ann, E.S., Lee, J.Y. Change of lipid metabolism during exercise according to UCP2 gene polymorphism in obesity man. Exercise Science, 14(1): 11-20, 2005. The purpose of the study was to compare lipid metabolism during treadmill exercise according to the UCP2 gene I/D polymorphism. A total of 39 apparently healthy volunteers (ID, n=10; DD, n=29; aged 20-30 years) were recruited via flyers and local advertisements. Anthropometric measurements included body weight, height, percent body fat, and cardio-respiratory fitness. Following an overnight fasting, the subjects performed exercise to 40% of VO2max on treadmill for 1 hour. Blood samples were collected from an anticubital vein into blood collecting tubes at rest, exercise 30minute, exercise 60minute, and recovery 1hour. The collected samples were used for analyses of blood lactate, glucose, triacylglicerol, free fat acid. And the respiratory exchange ratios were directly obtained from a metabolic cart every 10 minutes. Two-way analyses of variance showed a significant interaction effect between group and repetition(according to time) in blood lactate. In genotype comparison, DD homzygotes had significantly higher resting triacylglycerol and lactate concentrations than ID heterozygotes. The current findgs of the study suggest that although the UCP2 gene polymorphism itself is not related to lipid metabolism during exercise, the UCP2 D allele can be a genetic marker to the risks of obesity and cardiovascular disease.
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