UCP2 유전자 다형에 따른 비만여성의 유산소운동이대사증후군 위험 요인에 미치는 영향
Effects of 12-week Aerobic Exercise on the Metabolic Syndrome FactorsDependent on UCP2 Gene Polymorphism in Middle-Aged, Obese Women
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초록
연구배경 본 연구는 비만 중년여성의 유산소성운동이 UCP2 유전자 다형에 따라 대사증후군 위험요인에 미치는 영향을 규명하기 위해 실시하였다. 방 법 건강한 비만 중년여성 34명을 대상으로 혈액 분석을 통해 UCP2 유전자다형(DD, ID)을 구분한 후, UCP2 유전자다형과 운동실시 여부에 따라 총 4개 그룹을 분류하였다. 12주간 운동 전․후의 인체조성, 혈액분석을 통해 대사증후군 위험요인을 측정하고, 운동실시 여부와 UCP2 형질에 따른 상호작용 효과를 관찰하였다. 운동군은 개인별 60% VO2R 강도의 트레드밀 걷기를 1일 1시간, 주 3회, 총 12주간 실시하였다. 결 과 12주간의 유산소 운동 결과 체중, BMI, 수축기혈압에서 운동의 효과가 나타났지만, UCP2 유전자 형질에 따른 운동효과에 있어서는 통계적 유의차가 발견되지 않았다. 그러나 복부비만도에 있어서는 12주간의 유산소운동 결과 ID형질군에서만 유의한 감소효과가 나타났으며, 체지방율에 있어서도 ID형질군에서만 감소하는 경향성이 나타났다. 결 론 대사증후군 위험 요인에 대한 UCP2 유전자 형질에 따른 운동의 효과 비교에 있어서 ID형질과 DD형질 그룹 간의 유의차는 대체로 나타나지 않았으나, 복부 비만 관련 요인에 있어서는 ID형질이 DD형질에 비해 운동의 효과가 큰 것으로 나타났다.
Abstract
Background : The aim of this study was to investigate the effects of 12 weeks of aerobic exercise on the metabolic syndrome factors dependent on UCP2 gene polymorphismin middle-aged, obese women. Methods : A total of 34 healthy, obese women were recruited and classified according to UCP2 gene I/D polymorphism (ID, n=17; DD, n=17; middle-aged). Anthropometry (body weight, height, BMI and % body fat) and the metabolic syndrome factors(waist circumference, blood pressure, triglyceride, HDL-cholesterol and fasting blood glucose) were measured before and after the intervention. The exercise groups of each polymorphism group trained on the treadmill at an intensity of 60%VO2R for one hour every other day except weekends for 12 weeks. Results : Although there were significant 12-week aerobic exercise effects in body weight, BMI, VO2max, waist circumference and SBP, there was no significant exercise effects among UCP2 genotypes on the components of metabolic syndrome factors. However, WHR decreased significantly from 0.85 to 0.80 (p=.016), and % body fat dropped from 34.7% to 32.7% (p=.054) in the ID genotype while the DD genotype had no significant influence. Conclusions : In comparing the effects of exercise on metabolic syndrome factors according to the UCP2 genotypes, there was no significant difference between ID heterozygotes and DD homozygotes. However, this study showed that ID UCP2 genotype has more exercise effects on abdominal obesity-related factors (WHR and % body fat).
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