한국인에서의 CC Chemokine Receptor 5(CCR5) 유전자 다형성과 알레르기 비염 발생에 대한 연구
A Study of Prevalence between Allergic Rhinitis and CCR5 Gene Polymorphism Study of a Korean Population
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Abstract
Background and Objectives：C chemokine receptor (CCR5) is characteristic of the Th 1 phenotype, the receptor of RANTES, MIP-1αand MIP-1β. The receptor of CCR5 32 (a 32 bp deletion in the CCR5 gene, mutant type) results in the production of a non-functional receptor. Given the potential importance of CCR5 in allergic inflammation, we hypothesized that individuals carying the CCR5 32 allele would show a reduced prevalence of allergic rhinitis. ：Blood samples for genetic analysis were obtained from 187 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for the CCR5 gene polymorphism was used for genotyping. Results：We could not find the CCR5 32 homozygotes and heterozygotes at al in neither of the controls nor allergic rhinitis Korean patients. Conclusion：Since the CCR5 32 allele frequency did not deviate from that in the healthy control population, it is unlikely that this allele
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