한국인 알레르기비염 환자에서 TAP1 유전자 다형성에 관한 연구
Polymorphism of the Transporters Associated with Antigen Processing 1 (TAP1)Gene in Korean Patients with Allergic Rhinitis
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Abstract
Background and Objectives：Antigen peptides are actively transported across the endoplasmic reticulum by the transportersassociated with antigen processing (TAP) and presented to self-restricted cytotoxic T lymphocytes by the HLA class I molecules.Polymorphisms in TAP genes could influence the selection of peptides that bind to class I molecules. We designed a case-controlstudy to investigate the frequencies of TAP1 gene in control group and allergic rhinitis group, to analyze the association of TAP1polymorphism with allergic rhinitis, and to compare the frequencies of TAP1 haplotypes among the various ethnic groups.Subjects and Method：TAP1 genotyping were performed for 110 Korean allergic rhinitis patients and 107 healthy controls.TAP1 polymorphic residues at codon 333 and 637 were found using amplification refractory mutation system-polymerase chainreaction (ARMS-PCR). Results：The frequencies of Ile/Ile and Ile/Val genotypes at TAP1 codon 333 were 74.5%, 23.7% inallergic rhinitis, and 50.5%, 49.5% in controls, respectively. The odds ratio of Ile/Val was 0.43 (95%CI, 0.24-0.80) in relationto Ile/Ile (p=0.001). The frequencies of Asp/Asp and Asp/Gly genotypes at TAP1 codon 637 were 69.0%, 27.3% in allergicrhinitis, and 51.4%, 46.7% in controls, respectively. The odds ratio of Asp/Gly was 0.43 (95%CI, 0.24-0.80) in relation toAsp/Asp (p=0.011). Conclusion：TAP1 gene polymorphism may be an important factor for the pathogenesis of allergicrhinitis and it could determine the individual susceptibility of allergic rhinitis in the Korean population.
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