Glutathione S-Transferase 유전자 다형성을 이용한한국인 알레르기 비염환자에서의 감수성에 대한 연구
A Study of Susceptibility between Allergic Rhinitis andGlutathione S-Transferase Gene Polymorphism Study in Korean
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Abstract
Background and Objectives：Glutathione S-transferase (GST) enzymes have an important role in preventing the build-up of reactive oxygen species. Polymorphisms in genes involved in response to oxidative stress may play a role in the susceptibility to allergic diseases in human. A common homozygous deletion(null type) polymorphism of the GST gene abolishes the antioxidative enzyme activity. We investigated whether the profile of GSTM1 and GSTT1 genotypes might be associated with the risk of allergic rhinitis. Subjects and Method：Blood samples for genetic analysis were obtained from 287 individuals with allergic rhinitis and from 262 healthy subjects without atopic diseases. Multiplex polymerase chain reaction-based assay for GSTM1and GSTT1 was used for genotyping. Results：The null genotype was more frequent in controls and the frequencies of the genotypes of GSTM1 were statistically different between controls and patients (p<0.05). The null genotype was more frequent in controls, but there were no differences in the frequencies of the genotypes of GSTT1 in both groups (p>0.05). Conclusion：Our result suggests that the GSTM1 and GSTT1 polymorphism is not associated with the susceptibility to allergic rhinitis in Koreans.
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