IL-4 Receptor α 유전자다형성을 이용한 한국인알레르기비염환자에서의 감수성에 대한 연구

Abstract

Background and Objectives：The IL-4 receptor (IL-4R) gene has been suggested as a candidate gene for atopic diseases. The IL-4R consists of two subunits：the α chain (IL-4Rα), which is a high-affinity IL-4 binding site shared with the IL-13R, and the common γ chain shared with several other cytokine receptors that amplifies signalling of the α chain. A Gln551Arg polymorphism of the IL-4Rα gene was shown to be a gain-of-function mutation and was associated with atopy. We tested whether a Gln551Arg polymorphism of IL-4Rα gene is associated with allergic rhinitis, blood eosinophil counts and total serum IgE levels in the Korean population. Subjects and Method：Blood samples for genetic analysis were obtained from 192 individuals with allergic rhinitis and from 191 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for IL-4Rα Gln551Arg was used for genotyping. Serum total IgE levels were determined by using the immunoassay. Eosinophil values were determined by eosinophil numbers per total cell numbers per μL . Results：There were no differences in the frequencies of the genotypes of IL-4Rα in the controls and patients (p>0.05). The frequencies of the IL-4Rα Arg551 allele were statistically different between controls and patients (p>0.05). Blood eosinophil count and total serum IgE levels were not statistically different in the genotypes of IL-4Rα Gln551Arg in allergic rhinitis (p>0.05). Conclusion：Our result suggests that the IL-4Rα Gln551Arg polymorphism might not give susceptibility to the development of allergic rhinitis in Koreans.