STAT6 유전자의 G2964A 다형성을 이용한 한국인 알레르기 비염환자에서의 감수성에 대한 연구
A Study of Susceptibility between Allergic Rhinitis and STAT6 Gene G2964A Polymorphism Study of a Korean Population
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Abstract
Background and Objectives：T helper-type 2 cytokines, such as IL-4 and IL-13, may play a central role in allergic diseases. The proteins known as signal transducers and activators of transcription 6 (STAT-6) are key transcription factors involved in both IL-4 and IL-13 mediated biological responses. Since a polymorphism of STAT6 G2964A has been found, we investigated Subjects and Method：Blood samples for genetic analysis were obtained from 229 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for the STAT6 G2964A variant was used for genotyping. Results：There were no diferences in the frequencies of the genotypes bn etweethe controls and patients (p>0.05). The frequencies of the STAT6 2964A allele were not statisticaly diferent between controls and alergic rhinitis patients (p> ). Conclusion：Our result sugests that the STAT6 G2964A polymorphism might not give susceptibility to the development of allergic rhinitis in Koreans.
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