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Bisphenol A의 노출에 따른 조피볼락 (Sebastes schlegeli)의 혈액학적 영향

In vivo effects of bisphenol A exposure on haematological parameters in Korean rockfish, Sebastes schlegeli

지정훈|박수일|강주찬|금유화|이옥현
수산생명의학회 (Aquatic Life Medical Science)|2005.12|한국어병학회지 (JOURNAL OF FISH PATHOLOGY)|제18권 제3호|pp. 293-300

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참고문헌

초록

본 연구는 우리나라 주요 양식어류인 조피볼락을 대상으로 bisphenol A가 혈액에 어떠한 영향을 끼치는지를 조사하였다. 실험어를 대상으로 어체중 kg 당 0.1, 1 및 10 mg BPA를 0, 3, 7 및 12일째에 복강주사 한 후, 15일째에 그 영향을 조사하였다. BPA에 노출된 조피볼락은 적혈구수와 헤모글로빈의 농도가 유의한 감소를 나타내었고, 혈청 클로라이드, 칼슘, 혈당, 빌리루빈 및 요소질소의 농도는 증가하는 경향을 나타내었고, 콜레스테롤은 감소하였다. 또한, 혈청 전이효소와 젖산탈수소효소의 활성은 증가하였다.

Abstract

This study was conducted to investigate the effect of bisphenol A (BPA; 4,4‘-isopropylidenediphenol) on haematological parameters of Korean rockfish, Sebastes schlegeli in laboratory condition. Fish were randomly distributed into three treatment groups which were received of 0.1, 1 and 10 mg BPA kg-1 body weight. They were injected four times intraperitoneally at days 0, 3, 7 and 12 with BPA. Control group was subjected to the same regime using an equal volume of 60% ethanol-mixed PBS carrier injection only. Fish from each group were sacrificed on day 15 after first injection for haematological assay. Observations on haematological parameters indicated BPA-treatment induced lower level of red blood cell counts and hemoglobin concentration. Serum chloride, calcium, glucose, bilirubin and blood urea nitrogen concentrations increased following exposure to BPA at 10 mg kg-1 body weight. In contrast, serum cholesterol in fish exposed to BPA decreased. Serum transaminase and lactate dehydrogenase activities after the highest level of 10 mg kg-1 PBA was significantly increased. These results demonstrate that BPA have induced adverse impact on haematological parameters in the Korean rockfish, Sebastes schlegeli.

참고문헌 (30)

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