Melatonin이 수면에 미치는 영향
The Effects of Melatonin on Sleep
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Melatonin 복용 후 수면 각성 주기에 미치는 영향을 확인하기 위해, 19세에서 25세 (평균 22.0±2.1세) 사이의 소위 건강한 남자 대학생 지원자 16명을 대상으로 기준일, melatonin 6mg 투약 1일, 투약 2일, 투약 3일, 그리고 회복일간의 입면 잠시 반복 검사(MSLT), 스탠포드 졸리움 척도(SSS), 반응시간(RT)을 적용하여 실험한 결과를 요약하면 다음과 같다 1. 기준일과 비교하여, melatonin 6mg 투약 후 입면 잠시가 유의하게 짧아졌으며, 투약 후 1시간이내에 입면 잠시에 영향을 미쳤고, 그 지속시간은 7시간 정도였다. 2. 기준일과 비교하여, melatonin 6mg 투약 후 3시간이내에 유의하게 주관적 졸리움을 호소하였으며, 그 지속 시간은 7시간 정도였다. 3. 기준일과 비교하여, 투약 후 반응시간에 대한 영향이 없었다. 4. melatonin 복용 2일 째의 반응시간이 길어지면 melatonin 복용 3일째의 반응시간도 길어진다.
Abstract
OBJECTIVES : Author tried to evaluate the hypnotic effect of melatonin and melatonin induced daytime sleepiness and to identify the cumulative effect of short-term administration of melatonin for 3 successive days, and remaining effect after discontinuation. INTERVENTION : Subjects visited our laboratory by 08:00 at the first day, and they had baseline MSLT (from 10:00 to 22:00 at 2 hours' interval) while they had 7 naps during the day. Each time, the subjects completed SSS and RT before they underwent an MSLT to evaluate their sleepiness and to evaluate their performance. Next day, 6mg of melatonin was administered to healthy young males at 09:00 hour, and the concurrent effects on sleep latency, daytime sleepiness and reaction time were recorded. PARTICIPANTS : Sixteen healthy, normal young male college students participated in this study. Participating subjects were in good physical and psychological health and were asymptomatic as to sleep/wake complaints RESULT : The result were summarized as follows. 1. As compared to baseline, the hypnotic effect of melatonin appeared within 1 hour, and the effect continued over 7 hours. Sleep latency was normal range on the day of discontinuation. 2. Subjects had significantly more subjective daytime sleepiness after melatonin administration. Melatonin induced daytime sleepiness appeared within 3 hour after adminisration, and the condition continued over 7 hours. 3. Compared to baselines, there was no effect on reaction time. 4. The longer the reaction time of second drug administration day, the longer the reaction time of third drug administration day.